| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Research Abstract |
The changes in pharmacokinetics with aging of voriconazole, mycophenolic acid and valproate were investigated in human and rats. In all three drugs, pediatric patients were required a higher dose than adults to achive a similar the trough plasma concentration. I show that these differences are due to the activity of drug metabolism and the capacity of enterohepatic circulation, and suggest that changes of drug transpoter(s) expression over the course of development affect the disposition kinetics.
|
