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Research of Change in Pharmacokinetics as a Function of Age Intended Optimization of Drug Therapy in children

Research Project

Project/Area Number 21590154
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionKanazawa University

Principal Investigator

ISHIZAKI Junko  金沢大学, 薬学系, 准教授 (60401890)

Co-Investigator(Kenkyū-buntansha) MIYAMOTO Ken-ichi  金沢大学, 附属病院, 教授 (30100514)
Co-Investigator(Renkei-kenkyūsha) SUGA Yukio  金沢大学, 薬学系, 助教 (00467101)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords小児 / TDM / 適正使用 / ボリコナゾール / ミコフェノール酸 / バルプロ酸 / 薬物動態 / 成長過程 / 体内動態
Research Abstract

The changes in pharmacokinetics with aging of voriconazole, mycophenolic acid and valproate were investigated in human and rats. In all three drugs, pediatric patients were required a higher dose than adults to achive a similar the trough plasma concentration. I show that these differences are due to the activity of drug metabolism and the capacity of enterohepatic circulation, and suggest that changes of drug transpoter(s) expression over the course of development affect the disposition kinetics.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (19 results)

All 2012 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results) Remarks (7 results)

  • [Journal Article] Change in pharmacokinetics of mycophenolic acid as a function of age in rats and effect of coadministered amoxicillin/clavulanate2012

    • Author(s)
      Ishizaki, J., Tsuda, T., Suga, Y., Ito, S., Arai, K., Sai, Y., Miyamoto, K.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: (in press)

    • NAID

      130001872101

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Change in Pharmacokinetics of Mycophenolic Acid as a Function of Age in Rats and Effect of Coadministered Amoxicillin/Clavulanate2012

    • Author(s)
      Ishizaki.J
    • Journal Title

      Biological & Pharmaceutical Bulletin

      Volume: (In press)

    • NAID

      130001872101

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児と成人におけるボリコナゾールの血中濃度解析の比較2010

    • Author(s)
      伊藤さつき, 石崎純子, 小柴美紀恵, 五十嵐康郎, 長田直人, 菅幸生, 西村良成, 前馬秀明, 小泉晶一, 中尾眞二, 横川弘一, 崔吉道, 宮本謙一
    • Journal Title

      医療薬学

      Volume: 36 Pages: 213-219

    • NAID

      130004502587

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児と成人におけるボリコナゾールの血中濃度解析の比較2010

    • Author(s)
      伊藤さつき
    • Journal Title

      医療薬学 36

      Pages: 213-219

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 成長過程における抗てんかん薬バルプロ酸の薬物動態の変動2012

    • Author(s)
      東夏宵,石崎純子,菅幸生,荒井國三,崔吉道,宮本謙一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 成長過程における抗てんかん薬バルプロ酸の薬物動態の変動2012

    • Author(s)
      東夏宵
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] バルプロ酸の血漿中濃度と肝機能との関係2012

    • Author(s)
      河辺志帆,石崎純子,東夏宵,菅幸生,荒井國三,崔吉道,宮本謙一
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] バルプロ酸の血漿中濃度と肝機能との関係2012

    • Author(s)
      河辺志帆
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 成長過程における免疫抑制剤ミコフェノール酸の体内動態変動2010

    • Author(s)
      石崎純子,津田智子,菅幸生,荒井國三,崔吉道,宮本謙一
    • Organizer
      第20回日本医療薬学会年会
    • Place of Presentation
      幕張メッセ国際展示場(千葉県)
    • Year and Date
      2010-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 成長過程における免疫抑制剤ミコフェノール酸の体内動態変動2010

    • Author(s)
      石崎純子
    • Organizer
      第20回日本医療薬学会年会
    • Place of Presentation
      幕張メッセ国際展示場(千葉)
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児における免疫抑制剤ミコフェノール酸の体内動態2009

    • Author(s)
      津田智子,石崎純子,小柴美紀恵,長田直人,菅幸生,荒井國三,西村良成,谷内江昭宏,崔吉道,宮本謙一
    • Organizer
      第19回日本医療薬学会年会
    • Place of Presentation
      長崎県立総合体育館(長崎県)
    • Year and Date
      2009-10-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 小児における免疫抑制剤ミコフェノール酸の体内動態2009

    • Author(s)
      津田智子
    • Organizer
      第19回日本医療薬学会年会
    • Place of Presentation
      長崎県立総合体育館 (長崎県)
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/lab/joho.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/~druginfo/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/~druginfo/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/lab/joho.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/~druginfo/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/lab/joho.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.p.kanazawa-u.ac.jp/?druginfo/

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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