| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Opioid analgesics possess the interindividual variations in pharmacokinetics and drug responses. Limited clinical data on the factors determining the interindividual variations are available in cancer pain patients. To date, the pain relief for cancer patients using opioid analgesics is uniformly performed according to the current Japanese package insert in clinical practices. This study evaluated the pharmacokinetics of and drug responses and tolerance to opioid analgesics based on genetic polymorphisms of drug-metabolizing enzymes, drug-transporter, and opioid receptor, and cachexia in cancer pain patients.
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