Investigation of interindividual variability in pharmacokinetics of and clinical responses to opioid analgesics in cancer pain patients
Project/Area Number |
21590155
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Medical pharmacy
|
Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
NAITO Takafumi 浜松医科大学, 医学部附属病院, 副薬剤部長 (80422749)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | オピオイド鎮痛薬 / オキシコドン / がん性疼痛 / オーダーメイド医療 / 遺伝子多 / がん悪液質 / 緩和医療 / 悪液質 / 薬物動態 / オピオイド / 有害作用 / 代謝物 / 耐性形成 / 遊離形分率 / 有害反応 / アルブミン / α1酸性糖タンパク / 遺伝子多型 / CYP2D6 |
Research Abstract |
Opioid analgesics possess the interindividual variations in pharmacokinetics and drug responses. Limited clinical data on the factors determining the interindividual variations are available in cancer pain patients. To date, the pain relief for cancer patients using opioid analgesics is uniformly performed according to the current Japanese package insert in clinical practices. This study evaluated the pharmacokinetics of and drug responses and tolerance to opioid analgesics based on genetic polymorphisms of drug-metabolizing enzymes, drug-transporter, and opioid receptor, and cachexia in cancer pain patients.
|
Report
(4 results)
Research Products
(11 results)