Population pharmacokinetics and pharmacodynamics and individualized therapy in patients with refractory epilepsy
| Project/Area Number |
21590156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
YANO Ikuko 京都大学, 大学院・薬学研究科, 准教授 (50273446)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKUDO Masahide 京都大学, 大学院・医学研究科, 助教 (60437233)
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| Research Collaborator |
IKEDA Akio 京都大学, 大学院・医学研究科, 准教授 (90212761)
MASUDA Satohiro 京都大学, 大学院・医学研究科, 講師 (90303825)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | オーダーメイド医療 / 臨床薬物動態学 / 遺伝子 / 脳神経疾患 / 薬学 / 薬剤反応性 / 薬物動態学 / 薬物動態 / 薬力学 / P-糖タンパク質 / 遺伝学 / 母集団解析 |
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| Research Abstract |
We quantitatively evaluated the effects of CYP2C19 genotype and co-administered antiepileptics on clobazam and N-desmethylclobazam pharmacokinetics. The high N-desmethylclobazam concentration in CYP2C19 poor metabolizers suggested a higher possibility of response to low-dose clobazam, and genotyping of CYP2C19 might be useful in individualized therapy with this drug.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Significance of trough monitoring for tacrolimus blood concentration and calcineurin activity in adult patients undergoing primary living-donor liver transplantation2012
Author(s)
Yano I, Masuda S, Egawa H, Sugimoto Y, Fukudo M, Yoshida Y, Hashi S, Yoshizawa A, Ogura Y, Ogawa K, Mori A, Kaido T, Uemoto S, Inui K
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Journal Title
Eur J Clin Pharmacol
Volume: 68(3)
Issue: 3
Pages: 259-266
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Heterozygous variants of multidrug and toxin extrusions(MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients2010
Author(s)
Toyama K, Yonezawa A, Tsuda M, Masuda S, Yano I, Terada T, Osawa R, Katsura T, Hosokawa M, Fujimoto S, Inagaki N, Inui K
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Journal Title
Pharmacogenet. Genomics
Volume: 20(2)
Issue: 2
Pages: 135-138
DOI
Related Report
Peer Reviewed
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[Presentation] Significance of trough monitoring of tacrolimus blood concentration and calcineurin activity in living-donor liver transplant patients2011
Author(s)
Yano I, Masuda S, Egawa H, Sugimoto M, Fukudo M, Yoshida Y, Yasuda Y, Kaido T, Uemoto S, Inui K
Organizer
12th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology
Place of Presentation
Stuttgart,(Germany)
Year and Date
2011-10-05
Related Report
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