Understanding mechanisms underlying an increased sensitivity of central nervous system to therapeutic compounds with decreased renal function for dose optimization and individualizing treatment
| Project/Area Number |
21590159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
AIBA Tetsuya 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (00231754)
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| Co-Investigator(Kenkyū-buntansha) |
KUROSAKI Yuji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (90161786)
KAWASAKI Hiromu 岡山大学, 大学院・医歯薬学総合研究科, 教授 (60125151)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 腎障害 / 薬効変動 / 肝代謝 / 薬物代謝酵素 / 発現変動 / 脈絡叢 / 中枢神経 / CYP3A / NKCC1 / 炎症 / テーラーメード医療 / CYP3A2 / 腎不全 / 個体差 / 薬物感受性 / 薬物療法 / 投与設計 |
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| Research Abstract |
It has been elucidated that the hepatic expression of the drug metabolizing enzyme is altered with a decreased renal function. The expression of electrolyte transporter in choroid plexus also varies when renal function is impaired. These findings suggest that an increased sensitivity of central nervous system to therapeutic compounds is caused by the increase in the drug disposition to central nervous system. The increased drug disposition seems to be a result of an altered hepatic enzyme expression in conjunction with a perturbed homeostasis of central nervous system with an altered choroid plexial expression of electrolyte transporters.
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Report
(4 results)
Research Products
(66 results)
