Application of microdialysis techniques to evaluation system for local pharmacokinetics of topically delivered drugs guaranteeing regionally confined drug action
| Project/Area Number |
21590161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
KUROSAKI Yuji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (90161786)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASAKI Hiromu 岡山大学, 大学院・医歯薬学総合研究科, 教授 (60125151)
AIBA Tetsuya 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (00231754)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 薬物動態 / ドラッグデリバリー / マイクロダイアリシス / 微小透析 / 局所動態 / モニタリング / 局所 / 筋肉 / Lipo-MD / 血流 / 薬物送達 / lipo-MD |
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| Research Abstract |
A new drug delivery concept, which enables well-controlled regionally confined drug action, requires new scientific platform that covers topical bioavailability and topical pharmacokinetics. In this study, lateral diffusion and systemic transfer of drugs applied to the abdominal muscle of the rat was monitored by microdialysis(MD). Improved monitoring characteristics of Lipo-MD in followability of the donor concentration changes were clarified in application to lipophilic drugs.
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Report
(4 results)
Research Products
(18 results)
