| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Pharmacokinetics plays an important role in efficacy and safety pharmacotherapy. The estimation of pharmacokinetics parameters from one-point concentration data is desirable. In this study, i developed a stable numerical method for nonlinear optimization in pharmacokinetics. Moreover, I applied it to the least square methods to calculate the population parameters.
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