Bas i s stud i es on the appropr i ate usage of c l i n i ca I med i c i ne : i so form specificity of the functional interaction between drug metabolizing enzymes and the individual differences
| Project/Area Number |
21590164
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
ISHII Yuji 九州大学, 大学院・薬学研究院, 准教授 (90253468)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 薬物代謝 / UDP-グルクロン酸転移酵素 / グルクロン酸抱合 / シトクロムP450 / タンパク質間相互作用 |
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| Research Abstract |
Interaction between cytochP4so P450 CYPsA4YP3A4) and UDPglucuronosyltransferase(UGT) isoforms in COS cells was evidenced by an analysis using Fluorescence Resonance Energy Transfer. FurtCYPsA4YP3A4 affects the glucuronidation activity catalyzeUGTlAiGT1A7 and 1A3. However, the modifying effecCYPsA4YP3A4 differed between UGT isoforms. In addition, differences were also seen in the effecCYPsA4YP3AUGTlAiGT1A7 variants* 1,* 2 and* 3. Therefore, these results support the hypothesis that the interaction betCYPsA4YP3A4 and UGT is one of the determinants involved in the interindividual difference in glucuronidation. On the other hand, it is also suggested that some of the endogenous and foodderived compounds modulate UGT activity.
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Report
(4 results)
Research Products
(45 results)
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[Presentation] Yuki Iwamoto, Toshiya Oizaki, Arielf Nurrochmad, Yoshio Nishimura, Shin' ichi Ikushiro, Futoshi Taura, Satoshi Morimoto, Kiyoshi Nagata, Yasushi Yamazoe, Peter I. Mackenzie, Hideyuki Yamada. CytochromeP4so0 3A4 Enhances2009
Author(s)
Yuji Ishii
Organizer
UDP-lucuronosyltransferase 1A9-Catalyzed Glucuronidation of SN-s88, an Active Metabolite of Irinotecan. Abstract of papers,# 150, The 3rd Asian-Pacific Regional ISSX Meeting
Place of Presentation
Bangkok, Thailand, Drug Metab
Related Report
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