| Project/Area Number |
21590165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
FUMOTO Shintaro 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (70380988)
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| Research Collaborator |
MINE Toyoharu 長崎大学, 大学院・医歯薬学総合研究科, 大学院生
NAKAJIMA Sayuri 長崎大学, 薬学部, 学部学生
HIRATA Haruna 長崎大学, 大学院・医歯薬学総合研究科, 大学院生
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 医療薬剤学 / 腹膜透析 / 腹膜肥厚 / 腹膜透過性の亢進 / 診断薬 / 遺伝子治療 / プラスミドDNA / デキストラン / Plasmid DNA / マクロピノサイトーシス / EGF |
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| Research Abstract |
In this study, we developed an early diagnosis method for peritoneal damage during peritoneal dialysis. Using two marker substances having different molecular weight, we succeeded in evaluating both water-removing and substance-exchanging abilities of dialysis fluids simultaneously. Moreover, we successfully developed a gene transfer method to whole peritoneal organs using plasmid DNA and calcium carbonate particles. This method was simple, effective and safe in mice.
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