Development of early diagnosis and therapeutic methods for peritoneal damage during peritoneal dialysis
| Project/Area Number |
21590165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Nagasaki University |
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Principal Investigator |
FUMOTO Shintaro 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (70380988)
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| Research Collaborator |
MINE Toyoharu 長崎大学, 大学院・医歯薬学総合研究科, 大学院生
NAKAJIMA Sayuri 長崎大学, 薬学部, 学部学生
HIRATA Haruna 長崎大学, 大学院・医歯薬学総合研究科, 大学院生
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 医療薬剤学 / 腹膜透析 / 腹膜肥厚 / 腹膜透過性の亢進 / 診断薬 / 遺伝子治療 / プラスミドDNA / デキストラン / Plasmid DNA / マクロピノサイトーシス / EGF |
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| Research Abstract |
In this study, we developed an early diagnosis method for peritoneal damage during peritoneal dialysis. Using two marker substances having different molecular weight, we succeeded in evaluating both water-removing and substance-exchanging abilities of dialysis fluids simultaneously. Moreover, we successfully developed a gene transfer method to whole peritoneal organs using plasmid DNA and calcium carbonate particles. This method was simple, effective and safe in mice.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] H, Fumoto S, Nishida K. Multiple components in serum contribute to hepatic transgene expression by lipoplex in mice2011
Author(s)
Yoshikawa N, Sakamoto K, Mizuno S, Sakaguchi J, Miyamoto H, Mine T, Sasaki H, Fumoto S, Nishida K.
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Journal Title
Journal of Gene Medicine
Volume: 13
Pages: 632-643
Related Report
Peer Reviewed
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