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Cyclin-dependent kinase 2 down-regulates expression of drug-metabolizing enzymes UGT1A1 and CYP3A4 through phosphorylation of nuclear receptor PXR

Research Project

Project/Area Number 21590170
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

MIWA Masao  静岡県立大学, 薬学部, 名誉教授 (10046287)

Co-Investigator(Kenkyū-buntansha) SUGATANI Junko  静岡県立大学, 薬学部, 教授 (30098131)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsサイクリン依存性キナーゼ / 薬物代謝酵素 / 転写調節 / 核内受容体 / シグナル伝達 / CDK2 / 細胞周期 / 肝薬物代謝酵素 / 発現制御 / CDK 2 / シグナル伝逹
Research Abstract

We investigated how the expression of drug-metabolizing enzymes including UGT1A1and CYP3A4 is regulated by cell signals associated with cell-cycle progression. While the active form of CDK2(phospho-CDK2) peaked at 2 h and 4 h, respectively, and these levels dropped at 8 h, UGT1A1 and CYP2B6 were present at very low levels at 0 h to 6 h and started accumulating at 8 h. While CDK2 inhibitor roscovitine enhanced the expression of UGT1A1 and CYP3A4, it suppressed the expression of UGT1A1 and CYP3A4 in the cells transfected with S350D PXR. Phosphomimetic mutant at serine-350 of PXR was detected in the nuclei and lost the binding with RXR, and co-transfection with co-activator SRC-2 but not SRC-1 recovered PXR activity. These results indicate that roscovitine stimulated expression of UGT1A1 and CYP3A4 through inhibiting CDK2, which phosphorylated PXR at serine-350 to suppress the transactivation in the nuclei.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (60 results)

All 2012 2011 2010 2009 Other

All Journal Article (28 results) (of which Peer Reviewed: 28 results) Presentation (27 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Magsium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21Cip1 and p27Kip1 in renal epithelial NRK-52E cells2012

    • Author(s)
      Ikari A, Atomi K, Takiguchi A, Yamazaki Y, Hayashi H, Hirakawa J, Sugatani J
    • Journal Title

      J. Cell. Biochem

      Volume: 112 Issue: 12 Pages: 3563-3572

    • DOI

      10.1002/jcb.23284

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of dietary inulin, statin, and their co-treatment on hyperlipidemia, hepatic steatosis and changes in drug-metabolizing enzymes in rats fed a high-fat and high-sucrose diet2012

    • Author(s)
      Sugatani J, Sadamitsu S, Wada T, Yamazaki Y, Ikari A, Miwa M
    • Journal Title

      Nutr. Metab

      Volume: 9 Issue: 1 Pages: 23-46

    • DOI

      10.1186/1743-7075-9-23

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diet-induced lipid accumlation in liver enhances ATP-biding cassette transporter g5/g8 expression in bile canaliculi. Drug Metab2011

    • Author(s)
      Yamazaki Y, Hashizume T, Morioka H, Sadamitsu S, Ikari A, Miwa M, Sugatani J
    • Journal Title

      Pharmacokinet

      Volume: 208 Pages: 442-450

    • URL

      http://www.jstage.jst.go.jp/article/dmpk/26/5/26_442/_article

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decrease in claudin-2 expression enhances cell migration in renal epithelial Madin-Darby canine kidney cells2011

    • Author(s)
      Ikari A, Takiguchi A, Atomi K, Sato T, Sugatani J
    • Journal Title

      J. Cell. Physiol

      Volume: 226 Issue: 6 Pages: 1471-1478

    • DOI

      10.1002/jcp.22386

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Decrease in transient receptor potential melastatin 6 mRNA stability caused by rapamycin in renal tubular epithelial cells2011

    • Author(s)
      Ikari A, Sanada A, Sawada H, Okude C, Tonegawa C, Sugatani J
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1808 Pages: 1502-1508

    • URL

      http://dx.doi.org/10.1016/j.bbamem2010.11.006

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Claudin-2 knockdown decreases matrix metalloproteinase-9 activity and cell migration via suppression of nuclear Sp1 in A549 cells2011

    • Author(s)
      Ikari A, Atomi K, Kinjo K, Sasaki Y, Sugatani J
    • Journal Title

      Life Sci

      Volume: 88 Pages: 628-633

    • URL

      http://dx.doi.org/10.1016/j.lfs.2011.02.002

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal growth factor increases clathrin-dependent endocytosis and degradation of claudin-2 protein in MDCK II cells2011

    • Author(s)
      Ikari A, Takiguchi A, Atomi K, Sugatani J
    • Journal Title

      J. Cell. Physiol

      Volume: 226 Issue: 9 Pages: 2448-2456

    • DOI

      10.1002/jcp.22590

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21^<Cip1> and p27^<Kip1> in renal epithelial NRK-52E cells2011

    • Author(s)
      A.Ikari
    • Journal Title

      J.Cell.Biochem.

      Volume: 112 Pages: 3563-3572

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal growth factor increases clathrin-dependent endocytosis and degradation of claudin-2 protein in MDCK II cells2011

    • Author(s)
      A.Ikari
    • Journal Title

      J.Cell.Physiol.

      Volume: 226 Pages: 2448-2456

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Claudin-2 knockdown decreases matrix metalloproteinase-9 activity and cell migration via suppression of nuclear Sp1 in A549 cells2011

    • Author(s)
      A.Ikari
    • Journal Title

      Life Sci.

      Volume: 88 Issue: 13-14 Pages: 628-633

    • DOI

      10.1016/j.lfs.2011.02.002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decrease in transient receptor potential melastatin 6 mRNA stability caused by rapamycin in renal tubular epithelial cells2011

    • Author(s)
      A.Ikari
    • Journal Title

      Biochim.Biophys.Acta.

      Volume: 1808 Issue: 6 Pages: 1502-1508

    • DOI

      10.1016/j.bbamem.2010.11.006

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decrease in claudin-2 expression enhances cell migration in renal epithelial Madin-Darby canine kidney cells2011

    • Author(s)
      A.Ikari
    • Journal Title

      J.Cell.Physiol.

      Volume: 226 Pages: 1471-1478

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diet-induced lipid accumlation in liver enhances ATP-biding cassette transporter g5/g8 expression in bile canaliculi2011

    • Author(s)
      Y.Yamazaki
    • Journal Title

      Drug Metab.Pharmacokinet.

      Volume: 208 Pages: 442-450

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decrease in claudin-2 expression enhances cell migration in renal epithelial Madin-Darby canine kidney cells2011

    • Author(s)
      A.Ikari, et al.
    • Journal Title

      J Cell Physiol

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnesium deprivation inhibits a MEK-ERK cascade and cell proliferation in renal epithelial Madin-Darby canine kidney cells2010

    • Author(s)
      Ikari A, Atomi K, Kinjo K, Sasaki Y, Sugatani J
    • Journal Title

      Life Sci

      Volume: 86 Pages: 766-773

    • URL

      http://dx.doi.org/10.1016/j.lfs.2010.03.016

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells2010

    • Author(s)
      Ikari A, Sanada A, Okude C, Sawada H, Yamazaki Y, Sugatani J, Miwa M
    • Journal Title

      J Cell Physiol

      Volume: 222 Issue: 3 Pages: 481-487

    • DOI

      10.1002/jcp.21988

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nutritional status affects fluvastatinnduced hepatotoxicity and myopathy in rats2010

    • Author(s)
      Sugatani J, Sadamitsu S, Kurosawa M, Ikushiro S, Sakaki T, Ikari A, Miwa M
    • Journal Title

      Drug Metab. Dispos

      Volume: 38 Issue: 10 Pages: 1655-1664

    • DOI

      10.1124/dmd.110.034090

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 22010

    • Author(s)
      Sugatani J, Osabe M, Kurosawa M, Kitamura N, Ikari A, Miwa M
    • Journal Title

      Drug Metab. Dispos

      Volume: 38 Issue: 1 Pages: 177-186

    • DOI

      10.1124/dmd.109.029785

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular Mg2+regulates the tight junctional localization of claudin-16 mediated by ERK-dependent phosphorylation2010

    • Author(s)
      Ikari A, Kinjo K, Atomi K, Sasaki Y, Yamazaki Y, Sugatani J
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1798 Issue: 3 Pages: 415-421

    • DOI

      10.1016/j.bbamem.2009.11.005

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats.2010

    • Author(s)
      J.Sugatani, et al.
    • Journal Title

      Drug Melab.Dispos.

      Volume: 38(10) Pages: 1655-1664

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnesium deprivation inhibits a MEK-ERK cascade and cell proliferation in renal epithelial Madin-Darby canine kidney cells.2010

    • Author(s)
      A.Ikari, et al.
    • Journal Title

      Life Sci

      Volume: 86(19-20) Pages: 766-773

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular Mg(^<2+>) regulates the tight junctional localization of claudin-16 mediated by ERK-dependent phosphorylation.2010

    • Author(s)
      A.Ikari, et al.
    • Journal Title

      Biochim Biophys Acta

      Volume: 1798(3) Pages: 415-421

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity : Cell-cycle dependent expression2010

    • Author(s)
      J.Sugatani, et al.
    • Journal Title

      Drug Metab.Dispos 38(1)

      Pages: 177-186

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regularion of TRPM6 transcriptional activity by AP-1 in renal epithelial cells2010

    • Author(s)
      A.Ikari, et al.
    • Journal Title

      J Cell Physiol 222(3)

      Pages: 481-487

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress2009

    • Author(s)
      Osabe M, Sugatani J, Takemura A, Kurosawa M, Yamazaki Y, Ikari A, Miwa M
    • Journal Title

      FEBS Lett

      Volume: 583 Pages: 885-889

    • URL

      http://dx.doi.org/10.1016/j.febslet.2009.01.051

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal growth factor increases claudin-4 expression mediated by Sp1 elevation in MDCK cells. Biochem. Biophys2009

    • Author(s)
      Ikari A, Atomi K, Takiguchi A, Yamazaki Y, Miwa M, Sugatani J
    • Journal Title

      Res. Commun

      Volume: 384 Pages: 306-310

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2009.04.120

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress2009

    • Author(s)
      M.Osabe, et al.
    • Journal Title

      FEBS Letters 583(5)

      Pages: 885-889

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal growth factor increases claudin-4 expression mediated by Sp1 elevation in MDCK cells2009

    • Author(s)
      A.Ikari, et al.
    • Journal Title

      Biochem.Biophys.Res.Commun. 384(3)

      Pages: 306-310

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cyclin-dependent kinase 2 down-regulates expression of drug-metabolizing enzymes UGT1A1 and CYP3A4 through phosphorylation of nuclear receptor PXR in S phase2011

    • Author(s)
      内田貴啓、黒澤雅俊、平川城太朗、山崎泰広、五十里彰、三輪匡男、菅谷純子
    • Organizer
      第34回日本分子生物学会年会(横浜)
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Cyclin-dependent kinase 2 down-regulates expression of drug-metabolizing enzymes UGT1A1 and CYP3A4 through phosphorylation of nuclear receptor PXR in S phase2011

    • Author(s)
      内田貴啓、黒澤雅俊、平川城太朗、山崎泰広、五十里彰、三輪匡男、菅谷純子
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nutritional status influences basal and drug-induced expression of drug-metabolizing enzymes and transporters and drug-adverse effects2011

    • Author(s)
      Junko Sugatani
    • Organizer
      第26回日本薬物動態学会
    • Place of Presentation
      広島
    • Year and Date
      2011-11-18
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats : Association with the suppression of hepatic organic an ion transporting polypeptide 22011

    • Author(s)
      Junko Sugatani, Satoshi Sadamitsu, Masatoshi Kurosawa, Akira Ikari, Masao Miwa
    • Organizer
      4^<th> International conference on health and longevity sciences
    • Place of Presentation
      静岡
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 核内受容体を介したUGT1A1遺伝子転写調節2011

    • Author(s)
      菅谷純子
    • Organizer
      P450とUGTの勉強会
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 核内受容体を介したUGT1A1遺伝子転写調節2011

    • Author(s)
      菅谷純子
    • Organizer
      核内受容体を介したUGT1A1遺伝子転写調節
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] サイクリン依存性キナーゼ2は核内受容体PXRを介して薬物代謝酵素CYP3A42011

    • Author(s)
      内田貴啓、黒澤雅俊、平川城太朗、山崎泰広、五十里彰、三輪匡男、菅谷純子
    • Organizer
      UGT1A1の発現を負に調節する第75回日本生化学会中部支部シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2011-05-28
    • Related Report
      2011 Final Research Report
  • [Presentation] PAF受容体欠損マウスで見いだされた新規なPAF生理機能の解明2011

    • Author(s)
      菅谷純子、定光慧、山崎泰広、黒澤雅俊、長澤孝真、杉山渉、五十里彰、渡辺達夫、三輪匡男、石井聡、清水孝雄
    • Organizer
      第53回日本脂質生化学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] サイクリン依存性キナーゼ2は核内受容体PXRを介して薬物代謝酵素CYP3A4、UGT1A1の発現を負に調節する2011

    • Author(s)
      内田貴啓、黒澤雅俊、平川城太朗、山崎泰広、五十里彰、三輪匡男、菅谷純子
    • Organizer
      第75回日本生化学会中部支部シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 核内受容体PXRを介したUGT1A1発現調節機構の解析2011

    • Author(s)
      内田貴啓、黒澤雅俊、山崎泰広、五十里彰、三輪匡男、菅谷純子
    • Organizer
      第131年回日本薬学会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 酵素合成イヌリン添加食による脂肪肝増悪化抑制と連動した肝薬物代謝酵素発現変動の改善2010

    • Author(s)
      定光慧、和田正、長澤孝真、平本洸貴、五十里彰、三輪匡男、菅谷純子
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] CDKシグナル伝達系を介した核内受容体CAR発現調節機序の解明2010

    • Author(s)
      黒澤雅俊、内田貴啓、五十里彰、三輪匡男、菅谷純子
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2011 Final Research Report
  • [Presentation] CDKシグナル伝達系を介した核内受容体CAR発現調節機序の解明2010

    • Author(s)
      黒澤雅俊、内田貴啓、五十里彰、三輪匡男、菅谷純子
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats : Association with the suppression of hepatic organic anion transporting polypeptide 2.2010

    • Author(s)
      Junko Sugatani, Satoshi Sadamitsu, Masatoshi Kurosawa, Akira Ikari, Masao Miwa
    • Organizer
      3^<nd> International conference on health and longevity sciences "Integrated food-pharmaceutical science"
    • Place of Presentation
      静岡県立大学
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transcriptional regulation of human UDP-glucoronosyltransferase UGT1A1 gene expression and the alteration in its protein expression by intracellular factors controlling cell proliferation2010

    • Author(s)
      菅谷純子
    • Organizer
      第25回日本薬物動態学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Fluvastatin causes severer hepatic unjury and myopathy in rats fed a high-tat and high-sucrose diet than a standard diet : association with the suppression of hepatic organic anion transporting polypeptide 2.2010

    • Author(s)
      定光慧、黒澤雅俊、生城真一、榊俊之、五十里彰、二輪匡男、菅谷純子
    • Organizer
      第25回日本薬物動態学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Expression of UGT1A1 is regulated by cell signals associated with cell-cycle progression2010

    • Author(s)
      黒澤雅俊、内田貴啓、五十里彰、三輪匡男、菅谷純子
    • Organizer
      第25回日本薬物動態学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Expression of UGT1A1 is regulated by cell signals associated with cell-cycle progression.2010

    • Author(s)
      黒澤雅俊、内田貴啓、五十里彰、三輪匡男、菅谷純子
    • Organizer
      第25回日本薬物動態学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 細胞周期に依存した薬物代謝酵素の発現抑制2010

    • Author(s)
      黒澤雅俊、定光慧、山崎泰広、五十里彰、三輪匡男、菅谷純子
    • Organizer
      第130年回日本薬学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞周期に依存した薬物代謝酵素の発現制御2010

    • Author(s)
      黒澤雅俊, 定光慧, 山崎泰広, 五十里彰, 三輪匡男, 菅谷純子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] CDK2シグナル伝達系を介した薬物代謝酵素CYP2B6、UGT1A1発現調節機序の解明2009

    • Author(s)
      黒澤雅俊、長部誠、喜多村直美、山崎泰広、五十里彰、三輪匡男、菅谷純子
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2009-10-23
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 細胞増殖抑制シグナル伝達系と連携したCYP2B62009

    • Author(s)
      菅谷純子、長部誠、黒澤雅俊、山崎泰広、五十里彰、三輪匡男
    • Organizer
      UGT1A1発現調節機構の解明第2回博多シンポジウム「内・外環境と生物応答」
    • Place of Presentation
      博多
    • Year and Date
      2009-10-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞増殖抑制シグナル伝達系と連携したCYP2B6、UGT1A1発現調節機構の解明2009

    • Author(s)
      菅谷純子, 長部誠, 黒澤雅俊, 山崎泰広, 五十里彰, 三輪匡男
    • Organizer
      第2回博多シンポジウム「内・外環境と生物応答
    • Place of Presentation
      九州大学
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Induction of UGT1A1 and CYP 2B6 by an antimitogenic factor in HepG 2 cells is mediated through suppression of CDK2 activity2009

    • Author(s)
      Junko Sugatani, Makoto Osabe, Masatos hi Kurosawa, Yasuhiro Yamazaki, Akira Ikari
    • Organizer
      2nd International conf erence on health and longevity sciences, Yaku-shoku Dogen,'Medicine and food, sharing a common origin
    • Place of Presentation
      University of Shizuoka
    • Year and Date
      2009-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of CDK2 activity2009

    • Author(s)
      菅谷純子, 長部誠, 黒澤雅俊, 山崎泰広, 五十里彰
    • Organizer
      2^<nd> International conference on health and longevity sciences, Yaku-shoku Dogen, 'Medicine and food, sharing a common origin
    • Place of Presentation
      静岡県立大学
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞外シグナル伝達系と連携したグルクロン酸抱合酵素UGT1A1発現調節機構の解明2009

    • Author(s)
      黒澤雅俊、長部誠、山崎泰広、五十里彰、菅谷純子
    • Organizer
      UGT研究会2009
    • Place of Presentation
      静岡
    • Year and Date
      2009-09-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Cell cycle-dependent exp ression of CYP and UGT regulated by c yclin-dependent kinases in HepG2 and S W480 cells2009

    • Author(s)
      Junko Sugatani
    • Organizer
      16^<th> International Conference on Cytochrome P450.
    • Place of Presentation
      Okinawa(Nago)
    • Related Report
      2011 Final Research Report
  • [Book] Transcriptional regulation of human bilirubin : UDP-glucuronosyltransferase UGT1A1 gene and implication of defects in the UGT1A1 gene promoter in "Bilirubin : Chemistry, Regulation and Disorder" (Jakub F.Novotny and Florian Sedlacek eds)2012

    • Author(s)
      J.Sugatani, M.Miwa
    • Total Pages
      27
    • Publisher
      NOVA Science Publishers
    • Related Report
      2011 Annual Research Report
  • [Book] Transcriptional regulation of human bilirubin : UDP-glucuronosyltransferase UGT1A1 gene and implication of defects in the UGT1A1 gene promoter in "Bilirubin : Chemistry, Regulation and Disorder"2011

    • Author(s)
      Junko Sugatani and Masao Miwa
    • Publisher
      NOVA Science Publishers
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://w3pharm.u-shizuoka-ken.ac.jp/.rinsho/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://w3pharm.u-shizuoka-ken.ac.jp/~rinsho/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://w3pharm.u-shizuoka-ken.ac.jp/~rinsho/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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