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Effect of the intake of grapefruit juice on blood pressures in hypertensive patients treated with calcium channel blockers

Research Project

Project/Area Number 21590171
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

UCHIDA Shinya  静岡県立大学, 薬学部, 准教授 (80372522)

Co-Investigator(Kenkyū-buntansha) INUI Naoki  浜松医科大学, 医学部, 助教 (80402254)
IMAI Hiromitsu  大分大学, 医学部, 助教 (30398250)
TAKEUCHI Kazuhiko  浜松医科大学, 医学部, 准教授 (00419425)
YAMADA Hiroshi  静岡県立大学, 薬学部, 教授 (40265252)
Co-Investigator(Renkei-kenkyūsha) KOSUGE Kazuhiro  静岡県立大学, 薬学部, 講師 (00283375)
Research Collaborator TANAKA Shimako  静岡県立大学, 薬学部, 助教 (10559925)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords臨床薬学 / 相互作用 / 臨床効果 / グレープフルーツジュース / カルシウム拮抗薬 / 薬物相互作用 / 血漿中濃度 / 健康食品 / 降圧薬 / 臨床試験
Research Abstract

Grapefruit juice(GFJ) was reported to increase the concentration of calcium channel(Ca) blockers by inhibiting cytochrome P450(CYP) 3A4.The aim of this study was to clarify effect of the intake of GFJ on blood pressures in hypertensive patients treated with Ca blockers, amlodipine and nifedipine. Five Japanese patients consumed GFJ and water in 2-way crossover trial. Home blood pressures were measured by electrical devices. There was no significant difference of blood pressure of patients between GFJ phase and water phase(126/82 mmHg in GFJ phase vs 126/80 mmHg in water phase). In conclusion, there might be little impact of the intake of GFJ on blood pressure in hypertensive patients.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2012 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (8 results)

  • [Journal Article] Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam : an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers2011

    • Author(s)
      Shingen Misaka, Reiko Nakamura, Shinya Uchida, Kazuhiko Takeuchi, Norio Takahashi, Naoki Inui, Kazuhiro Kosuge, Shizuo Yamada, Hiroshi Watanabe
    • Journal Title

      Clin. Ther

      Volume: 33 Pages: 246-252

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Benzbromarone pharmacokinetics and pharmacodynamics in different cytochrome P450 2C9 genotypes2010

    • Author(s)
      Shinya Uchida, Kayoko Shimada, Shingen Misaka, Hiromitu Imai, Yasuhiro Katoh, Naoki Inui, Kazuhiko Takeuchi, Takashi Ishizaki, Shizuo Yamada, Kyoichi Ohashi, Noriyuki Namiki, Hiroshi Watanabe
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 25 Pages: 605-610

    • NAID

      10027743998

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Onset of Clinical Effects and Plasma Concentration of Fluvoxamine in Japanese2010

    • Author(s)
      Yasuhiro Katoh, Shinya Uchida, Masayoshi Kawai, Noriyoshi Takei, Norio Mori, Junichi Kawakami, Yoshiyuki Kagawa, Shizuo Yamada, Noriyuki Namiki, Hisakuni Hashimoto
    • Journal Title

      Biol. Pharm. Bull

      Volume: 33 Pages: 1999-2002

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetics and pharmacodynamics of midazolam administered intravenously and orally at low doses to healthy volunteers2010

    • Author(s)
      Shingen Misaka, Shinya Uchida, Hiromitsu Imai, Naoki Inui, Shinichiro Nishio, Kyoichi Ohashi, Hiroshi Watanabe, Shizuo Yamada
    • Journal Title

      Clin. Exp. Pharmacol. Physiol

      Volume: 37 Pages: 290-295

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Benzbromarone pharmacokinetics and pharmacodynamics in different cytochrome P450 2C9 genotypes.2010

    • Author(s)
      Shinya Uchida, et al
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 25 Pages: 605-610

    • NAID

      10027743998

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Onset of Clinical Effects and Plasma Concentration of Fluvoxamine in Japanese.2010

    • Author(s)
      Yasuhiro Katoh, Shinya Uchida, et al
    • Journal Title

      Biol.Pharm.Bull.

      Volume: 33 Pages: 1999-2002

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacokinetics and pharmacodynamics of midazolam administered intravenously and orally at low doses to healthy volunteers2010

    • Author(s)
      Shingen Misaka, Shinya Uchida, et al
    • Journal Title

      Clin.Exp.Pharmacol.Physiol.

      Volume: 37 Pages: 290-295

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 平成20年度診療報酬等の改訂に伴う後発医薬品の使用状況に関する保険薬局へのアンケート調査2009

    • Author(s)
      中島優太、金子貴則、近都正幸、渡邉崇之、小菅和仁、松山耐至、村越邦孫、賀川義之、山田浩
    • Journal Title

      臨床薬理

      Volume: 40 Pages: 295-302

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 平成20年度診療報酬等の改訂に伴う後発医薬品の使用状況に関する保険薬局へのアンケート調査2009

    • Author(s)
      中島優太, 山田浩, 他
    • Journal Title

      臨床薬理 40

      Pages: 295-302

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] カルシウム拮抗薬治療中の高血圧患者の家庭血圧に及ぼすグレープフルーツジュースの影響2012

    • Author(s)
      増井直登、内田信也、三浦基靖、竹下愛美、深井幸恵、田中紫茉子、井上達秀、並木徳之、山田浩
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 薬物相互作用検出のためのin vivoでのラットおよび健常人対象試験2011

    • Author(s)
      内田信也、田中紫茉子、乾直輝、竹内和彦、渡邉裕司、大橋京一、並木徳之
    • Organizer
      第32回日本臨床薬理学会年会
    • Place of Presentation
      浜松
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] In-vivo phenotyping for CYP3A4 by determination of a single-point plasma concentration and urinary excretion of midazolam and its metabolites2010

    • Author(s)
      Shinya Uchida, Motoyasu Miura, Shingen Misaka, Yasuhiro Katoh, Shizuo Yamada, Kyoichi Ohashi, Hiroshi Watanabe, Noriyuki Namiki
    • Organizer
      16th IUPHAR WorldCongress of Basis and Clinical Pharmacology
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2010-07-22
    • Related Report
      2011 Final Research Report
  • [Presentation] In-vivo phenotyping for CYP3A4 by determination of a single-point plasma concentration and urinary excretion of midazolam and its metabolites.2010

    • Author(s)
      Shinya Uchida, 他
    • Organizer
      16th IUPHAR WorldCongress of Basis and Clinical Pharmacology
    • Place of Presentation
      Copenhagen, Denmark
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミダゾラム及び代謝物の尿中排泄量と血漿中濃度時間曲線下面積との関係2010

    • Author(s)
      三浦基靖、内田信也、三坂眞元、加藤安宏、山田静雄、大橋京一、渡邉裕司、並木徳之
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] ミダゾラム及びその代謝物の尿中排泄量を用いたCYP3A4活性評価2009

    • Author(s)
      内田信也、三浦基靖、三坂眞元、加藤安宏、山田静雄、大橋京一、渡邉裕司、並木徳之
    • Organizer
      第30回日本臨床薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-03
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Influence of CYP2C9 genotypes on pharmacokinetics and pharmacodynamics of nateglinide in healthy volunteers and patients with 2 diabetes mellitus2009

    • Author(s)
      Shinya Uchida, Yasuhiro Katoh, Takeshi Ito, Hiroshi Morita, Hirotoshi Nakamura, Noriyuki Namiki, Hiroshi Watanabe, Kyoichi Ohashi
    • Organizer
      Asian Federation for Pharmaceutical Sciences
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Influence of CYP2C9 genotypes on pharmacokinetics and pharmacodyna mics of nateglinide in healthy volunteers and patients with 2 diabetes mellitus2009

    • Author(s)
      内田信也
    • Organizer
      Asian Federation for Pharmaceutical Sciences
    • Place of Presentation
      Fukuoka
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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