| Project/Area Number |
21590175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
NAKASHIMA Emi 慶應義塾大学, 薬学部, 教授 (90115254)
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| Co-Investigator(Kenkyū-buntansha) |
TOMI Masatoshi 慶應義塾大学, 薬学部, 准教授 (30334717)
NISHIMURA Tomohiro 慶應義塾大学, 薬学部, 助教 (40453518)
KOSE Noriko 慶應義塾大学, 薬学部, 研究員 (60348612)
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| Co-Investigator(Renkei-kenkyūsha) |
SAI Yoshimichi 金沢大学, 大学病院, 准教授 (40262589)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 薬物動態 / 代謝学 / 血管内皮前駆細胞 / 壁細胞 / bFGF / SMA / ケモタキシス / 管腔形成能 / 血管新生阻害 / 抗がん薬 / CD133 / 抗がん剤 / 血管新生 / 腫瘍増殖抑制 / 骨髄由来血管内皮細胞 / 遊走能 / タキサン系抗がん剤 / 微小血管密度低下 |
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| Research Abstract |
In formation process of a blood-tissue barrier, there is an interaction between specific tissue cells and bone marrow(BM)-derived endothelial progenitor cells(EPC). An assay system using the established cell lines from the specific tissue is desirable to obtain reproducible analysis. By using an established bone marrow-derived vascular endothelium precursor cell line, TR-BME, docetaxel and paclitaxel directly inhibited EPC-initiated vasculogenesis at low(non-cytotoxic) concentrations, causing suppression of tumor growth.
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