| Project/Area Number |
21590183
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATOH Miki 名城大学, 薬学部, 准教授 (70345594)
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| Co-Investigator(Renkei-kenkyūsha) |
ANDO Yoshinori 名城大学, 理工学部, 教授 (30076591)
HARUNA Mitsumasa 名城大学, 薬学部, 教授 (10076755)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | カーボンナノチューブ / 水溶化 / 蛍光ラベル化 / 体内動態特性 / 精製 / アミノ化 / 薬物動態 / ドラッグデリバリー |
|---|
| Research Abstract |
Recently, clinical application of single-walled carbon nanotube(SWCNT) has been proposed as drug delivery agents. In the present study, water-soluble fluorescent SWCNT(Cy5-PEG-CNT) has been synthesized by binding to fluorescent dye Cy5 and polyethylene glycol(PEG) in order to elucidate the pharmacokinetic properties of SWCNT. When Cy5-PEG-CNT was administered intravenously in Wistar rats, elimination rate from plasma was affected by its molecular weight. Disappearance of Cy5-PEG-CNT with low molecular weight from plasma was faster than that with high molecular weight. Cy5-PEG-CNT was excreted into urine and bile and the total cumulative amount of excretion was 60.70% of the dose administered. Cy5-PEG-CNT with low and high molecular weights was mainly excreted into the urine and bile, respectively. These findings suggest that the pharmacokinetics of SWCNT is able to control by changing the physicochemical properties.
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