Analysis of mtabolome in relation to endocrinological and metabolic diseases by soft ionization mass spectrometry
Project/Area Number |
21590184
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Medical pharmacy
|
Research Institution | Kinki University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
MITAMURA Kuniko 近畿大学, 薬学部, 准教授 (70242526)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 臨床化学 / LC/MS / 胆汁酸 / テトラヒドロコルチコステロイド / グルタチオン / 安定同位元素標識体 / サルフェート / エレクトロスプレーイオン化 / メタボローム / エレクロトスプレーイオン化 / LC / MS / ステロイドホルモン / オキシステロール / N-アセチルシステイン |
Research Abstract |
Highly sensitive and specific soft ionization mass spectrometry for the determination of tetrahydrocorticosteroids, bile acids, and oxysterols, which are conjugated with glucuronic and sulfuric acids, glutathione, and N-acetylcysteine, have been developed. The developed methods were useful for diagnosis of endocrinological and metabolic diseases.
|
Report
(4 results)
Research Products
(125 results)
-
-
-
-
[Journal Article] Synthesis of 3-and 21-monosulfates of[2, 2, 3ss, 4, 4-^<2> H_5]-tetra-hydrocorticosteroids in the 5ss-series as internal standards for mass spectrometry2011
Author(s)
Ikegawa S, Nagae K, Mabuchi T, Okihara R, Hasegawa M, Minematsu T, Iida T, Mitamura K
-
Journal Title
Steroids
Volume: 76
Pages: 1232-1240
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Potential corticoid metabolites : chemical synthesis of 3-and 21-mono-and 3, 21-disulfate conjugates of tetrahydrocorticosteroids in the 5α-and 5ss-series2010
Author(s)
Okihara R, Mitamura K, Hasegawa M, Mori M, Muto A, Kakiyama G, Iida T, Shimada M, Mano N, Ikegawa S
-
Journal Title
Chem. Pharm. Bull
Volume: 58
Pages: 344-353
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-