| Project/Area Number |
21590192
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Gunma University |
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Principal Investigator |
MURAKAMI Tohru 群馬大学, 大学院・医学系研究科, 准教授 (10239494)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 発生学・形態形成学 / 細胞接着 / 発生・分化 / 脳・神経 / プロトカドヘリン / ゼブラフィッシコ / 発生分化 / ゼブラフィッシュ / in situハイブリダイゼーション |
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| Research Abstract |
This project was to elucidate the functional significance of the diversity of the delpta-protocadherins (Pcdh's) in the development of the CNS and various organs using zebrafish as an experimental model. Pcdh9 started to express in some cells of the forebrain, the ventral hindbrain, and the spinal cord. Its expression in the brain increased over development, while that in the spinal cord decreased. The expression pattern of Pcdh17 was similar to that of Pcdh9, though had distinct differences in detailed patterns. The expression of Pcdh19 started in the neural keel, and expanded to the brain, the eyes, and the otocysts. Pcdh10a specifically expressed in the lens, the otocysts, and certain parts of the brain. Knock-down of Pcdh10a caused deformities of eye structures, though its penetration was relatively low, suggesting unknown complementary adhesion molecules.
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