PKCdelta molecules specifically expressed in testis
| Project/Area Number |
21590204
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Showa University |
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Principal Investigator |
NIINO Yuko 昭和大学, 医学部, 兼任講師 (60398683)
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| Co-Investigator(Kenkyū-buntansha) |
SHIODA Seiji 昭和大学, 医学部, 教授 (80102375)
OGURA Kiyoshi 東京都医学総合研究所, 主任研究員 (70233492)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 精子形成 / PKCデルタ / ノックアウトマウス / 精巣 / リン酸化基質 / 生殖細胞 / プロテインキナーゼC / リン酸化 / 細胞分化 / MS / PKC |
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| Research Abstract |
In the present study by this fund, we performed (1) generation of the transgenic mice of Cre genes to generate PKCdelta conditional knockout mice, (2) confirmation the PKC deltaIV～ VII molecules were not involved in the apoptosis, (3) search for the substrates of the PKCdeltaIV, (4) search for the molecules in the downstream of PKCdeltaIV.
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Report
(4 results)
Research Products
(9 results)
