| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Various proteins are required in the establishment of neuronal polarity. In this study, we analyzed mice deficient in VAMP7, a protein proposed to be involved in axonal transport. Contrary to expectations, VAMP7 knockout mice displayed similar localization of axonal proteins in the nervous system. However, neurite outgrowth of cultured mutant hippocampal neurons was slightly affected, suggesting that VAMP7 have some role in polarized transport of axonal proteins. This work was published in Traffic, an international journal of intracellular transport.
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