Structural and morphology changes in the disease model after amnion stem cell transplantation
| Project/Area Number |
21590212
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | University of Toyama |
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Principal Investigator |
YOSHIDA Toshiko 富山大学, 大学院・医学薬学研究部(医学), 准教授 (00171421)
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| Co-Investigator(Kenkyū-buntansha) |
NIKAIDO Toshio 富山大学, 大学院・医学薬学研究部(医学), 教授 (50180568)
OKABE Motonori 富山大学, 大学院・医学薬学研究部(医学), 助教 (60283066)
KOIKE Chika 富山大学, 大学院・医学薬学研究部(医学), 助教 (10523889)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ヒト羊膜細胞 / 疾患モデル / 分化誘導 / 糖尿病モデル / 脊髄損傷モデル / 骨欠損モデル / 骨分化 / 幹細胞マーカー / 糖尿病モデルマウス / インスリン分泌細胞 / 軟骨分化 / 免疫組織学的検討 / 羊膜上皮細胞 / 羊膜間葉系細胞 / Oct3 / 4 / Nanog / 羊膜幹細胞 / ラット |
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| Research Abstract |
The stem cells contained in an amnion epithelium cells and mesenchymal cells in the amnion membrane were purified. The stem cells were transported in to disease model.
In the diabetes model, blood glucose level became low temporarily and survival benefit was seen. In the cord injury model, in spite of having transplanted the mesenchymal cells one week after damage, the motor function was recovered significantly. In the bone deficit model, in spite of xenograft, rejection hardly started but the bone tissue has been reproducing.
The amnion stem cells were effective as a cell material of regeneration medicine.
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Report
(4 results)
Research Products
(88 results)
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[Journal Article] Establishment of Immortalized Human Amniotic Mesenchymal Stem Cells2012
Author(s)
Teng Z., Yoshida T., Okabe M., Toda A., Higuchi O., Nogami M., Yoneda N., Zhou K., Kyo S., Kiyono T., Nikaido T.
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Journal Title
Cell Transplant
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Establishment of Immortalized Human Amniotic Mesenchymal Stem Cells2011
Author(s)
Teng Z., Yoshida T., Okabe M., Toda A., Higuchi 0., Nogami M., Yoneda N., Zhou K., Kyo S., Kiyono T., and Nikaido T.
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Journal Title
Cell Transplant
Volume: (in pres)
Related Report
Peer Reviewed
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[Journal Article] A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour2010
Author(s)
Ito M., _Nakasima A., Hidaka T., Okabe M., Bac ND., Ina S., Yoneda S., Shiozaki A., Sumi S., Tuneyama K., Nikaido T., Saito S.
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Journal Title
J Reprod Immunol
Volume: 84
Pages: 75-85
Related Report
Peer Reviewed
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[Presentation] 新規ヒト乾燥羊膜(Hyper-Dry羊膜)の臨床における有用性2011
Author(s)
岡部素典,吉田淑子,小池千加,林央周,藤坂実千郎,将積日出夫,新井直也,津野宏彰,北川清隆,遠藤俊郎,渡邉行雄,野口誠,林篤志,齋藤滋,二階堂敏雄
Organizer
第10回日本再生医療学会総会
Place of Presentation
東京
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