| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We observed the expression of receptor tyrosine kinase, c-Kit and PDGFRα, that are specific markers of interstitial cells of Cajal and fibroblast-like cells in the murine gastrointestinal tract. c-Kit expression was observed in gastrointestinal tract from mid embryonic stage. W mutant mice that have c-kit mutations showed cell type specific deficiency of interstitial cells of Cajal. PDGFRαexpression in gastrointestinal tract was observed from early embryonic stage in mesoderm cells and in fibroblast-like cells in late embryonic stage.
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