Receptor tyrosine kinase-mediated development and differentiation of interstitial cells in the gastrointestinal tract
Project/Area Number |
21590213
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General anatomy (including Histology/Embryology)
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Research Institution | University of Fukui |
Principal Investigator |
IINO Satoshi 福井大学, 医学部, 教授 (40242854)
|
Co-Investigator(Kenkyū-buntansha) |
HORIGUCHI Kazuhide 福井大学, 医学部, 講師 (20377451)
|
Co-Investigator(Renkei-kenkyūsha) |
HORIGUCHI Satomi 福井大学, 医学部, 特命助教 (00595283)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 消化管間質細胞 / カハール介在細胞 / 消化管神経系 / Wミュータントマウス / c-Kit / PDGF受容体α / SK3チャネル / 消化管運動 / 消化管 / 線維芽細胞 / SK3 / 消化管神経 / 間質細胞 |
Research Abstract |
We observed the expression of receptor tyrosine kinase, c-Kit and PDGFRα, that are specific markers of interstitial cells of Cajal and fibroblast-like cells in the murine gastrointestinal tract. c-Kit expression was observed in gastrointestinal tract from mid embryonic stage. W mutant mice that have c-kit mutations showed cell type specific deficiency of interstitial cells of Cajal. PDGFRαexpression in gastrointestinal tract was observed from early embryonic stage in mesoderm cells and in fibroblast-like cells in late embryonic stage.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Acupuncture modulates mechanical responses of smooth muscle produced by transmural nerve stimulation in gastric antrum of genetically hyperglycemic rats2009
Author(s)
H. Fukuta, M. Koshita, E. Nakamura, . Nakamura, A. Yamada, Y. Kawase, T. Ishigami, Y. Kurono, S. Iino, H. Suzuki
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Journal Title
Journal of Smooth Muscle Research
Volume: 45
Issue: 4
Pages: 167-185
DOI
NAID
ISSN
0916-8737, 1884-8796
Related Report
Peer Reviewed
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