mitochondrial multipotent functions regulated by estrogen receptor
| Project/Area Number |
21590216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | University of Miyazaki (2011)
Nagasaki University (2009-2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Yoko 山口大学, 農学部, 学術研究員 (50398963)
KOJI Takehiko 長崎大学, 大学院・医歯薬学総合研究科, 教授 (30170179)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ミトコンドリア / エストロゲン受容体 / アポトーシス / RNA干渉 / 精巣 / エレクトロポーション / エストロゲン / 免疫組織化学 / エレクトロポレーション / DNAメチル化 / 転写因子 / サウスウエスタン組織化学 |
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| Research Abstract |
We investigated the correlation with the distribution of mitochondria and their components including ERβlocalization using a mitochondria vector(pEYFP-Mito), and small interfering RNA(siRNA) to knock down ERβtransfected into mouse testes. Mitochondrial proteins and ERβwere identical to pEYFP-Mito transfected cells. ERβsiRNA assay revealed that the reduction of ERβinduced the increased number of Bax positive cells. The change of mitochondrial location may be associated with germ cell apoptosis, potentially regulated by estrogen through ERβ.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] Aberrant expression of interferon regulatory factor 3 in human lung cancer.2010
Author(s)
Tokunaga T, Naruke Y, Shigematsu S, Kohno T, Yasui K, Ma Y, Chua KJ, Katayama I, Nakamura T, Hishikawa Y, Koji T, Yatabe Y, Nagayasu T, Fujita T, Matsuyama T, Hayashi H
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 397
Pages: 202-207
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Peer Reviewed
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[Journal Article] Human papillomavirus infection and its possible correlation with p63 expression in cervical cancer in Japan, Mongolia, and Myanmar2009
Author(s)
Shirendeb U, Hishikawa Y, Moriyama S, Win N, Thu MMM, Mar KS, Khatanbaatar G, Masuzaki H, Koji T
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Journal Title
Acta Histochem. Cytochem
Volume: 42
Pages: 181-190
NAID
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Peer Reviewed
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[Presentation] 脳卒中自然発症高血圧ラット(SHRSP)腎におけるオルメサルタンとアゼルニジピンのapoptosis inhibitor of macrophage(AIM)発現制御を介した腎保護効果の検討2009
Author(s)
浦松正, 古巣朗, 小畑陽子, 西野友哉, 阿部克成, 蔵重智美, 廣瀬弥幸, 宮崎正信, 船越哲, 菱川善隆, 宮崎徹, 小路武彦, 河野茂
Organizer
第18回日本Cell Death学会学術集会
Place of Presentation
長崎
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