Analysis of crosstalk between the central nervous system and peripheral organs involving galanin-like peptide(GALP)
| Project/Area Number |
21590222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIODA Seiji 昭和大学, 医学部, 教授 (80102375)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 遺伝子改変動物 / 緑色蛍光タンパク質 / 視床下部 / 自律神経 / 末梢神経 / ガラニン様ペプチド / 交感神経 / 迷走神経 / トランスジェニックマウス / 遠心性神経活動 / 求心性神経活動 / Cre-loxP / 機能形態学 / 末梢臓器 / 脳-末梢臓器間相互作用 / cre-loxP / 脂肪組織 |
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| Research Abstract |
Galanin-like peptide(GALP) is a neuropeptide related to feeding behavior and energy metabolism. GALP is produced in the hypothalamus arcuate nucleus. GALP also is present in the circulation. We hypothesized a linkage between the central nervous system(CNS) and peripheral organs. In order to demonstrate our hypothesis, we identified GALP mRNA expression in the several organs using RT-PCR, and measured neuronal activities of autonomic nervous system after GALP intravenous injection using electrophysiological techniques. We found that GALP mRNA expressed in the many organs. In addition, we found that GALP activated efferent sympathetic nerve. Vagotomy blocked the activation by GALP. GALP suppressed both afferent and efferent vagus nerves. These results suggest that GALP in circulation sends information to the CNS through vagal afferents and then regulates outputs of autonomic nerves in the CNS.
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Report
(4 results)
Research Products
(62 results)
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[Journal Article] Distribution of neuroendocrine regulatory peptide-1 and-2, and proteolytic processing of their precursor VGF protein in the rat2010
Author(s)
Mishiro-Sato E, Sasaki K, Matsuo T, Kageyama H, Yamaguchi H, Date Y, Matsubara M, Ishizu T, Yoshizawa-Kumagaye K, Satomi Y, Takao T, Shioda S, Nakazato M, Minamino N.
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Journal Title
J Neurochem
Volume: 114
Pages: 1097-1106
Related Report
Peer Reviewed
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[Journal Article] Neuropeptide W : an anorectic peptide regulated by leptin and metabolic state2010
Author(s)
Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S, Cone RD, Nakazato M.
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Journal Title
Endocrinology
Volume: 151
Pages: 2200-2210
Related Report
Peer Reviewed
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[Journal Article] Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system2009
Author(s)
Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Bachman ES, Kim YB, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y.
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Journal Title
Cell Metab
Volume: 10
Pages: 466-480
Related Report
Peer Reviewed
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