The role of Sox13 in the signaling pathway that controls epithelial-mesenchymal interaction

• Project/Area Number: 21590224
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Nippon Medical School
• Principal Investigator: OSADSA Shin-ichi 日本医科大学, 医学部, 助教 (00244484)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 細胞分化 / 組織形成 / 発生・分化 / 毛包形成 / 転写因子 / Sox / 発現制御 / シグナル伝達 / 癌

Research Abstract

Hair grows through the hair cycle consisting of anagen, catagen and telogen. We investigated the role of Sox13, a member of the Sox family of transcription factors that are involved in cell fate determination and differentiation, using Sox13 mutant mice. We found that Sox13 expression in hair follicle is dynamically changed during hair cycles, indicating that Sox13 is a novel hair cycle maker. Elucidation of the mechanism underlying the Sox13 cyclic expression would be important for understanding the pathogenesis of alopecia.

Research Products

• [Journal Article] Sebaceous Carcinoma of the Nose with a Regional Metastasis Following Falsenegative Sentinel Lymph Node Biopsy (2011)
  • Author(s): 長田真一
  • Journal Title: Acta Derm-Venereol Volume: (In press)
  • Peer Reviewed
• [Journal Article] Revascularization by Percutaneous Transluminal Angioplasty Improved Abruptly Deteriorated Ischemic Symptoms in Cutaneous Polyarteritis Nodosa (2011)
  • Author(s): 長田真一
  • Journal Title: Clin Exp Dermatol Volume: (In press)
  • Peer Reviewed
• [Journal Article] Case of livedoid vasculopathy with peripheral neuropathy successfully treated with low-dose warfarin. (2010)
  • Author(s): 長田真一
  • Journal Title: J.Dermatol. 37 Pages: 98-101
  • NAID: 10027065559
  • Peer Reviewed
• [Journal Article] Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth (2009)
  • Author(s): K ato M, Hasunuma N, Nakayama R, Takeda J, Itami S, Taira M, Manabe M, Osada S
  • Journal Title: J Dermatol Sci Volume: 53 Issue: 3 Pages: 234-236
  • DOI: 10.1016/j.jdermsci.2008.10.002
  • NAID: 10025332926
  • Peer Reviewed
• [Journal Article] Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth. (2009)
  • Author(s): 長田真一
  • Journal Title: J.Dermatol. Sci 53 Pages: 234-236
  • NAID: 10025332926
  • Peer Reviewed
• [Presentation] The expression of Sox13 in mouse hair development (2012)
  • Author(s): Shin-Ichi Osada, ら
  • Organizer: The 34th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 京都・国際会議場
  • Year and Date: 2012-12-10
• [Presentation] 毛周期におけるSox13の発現解析 (2011)
  • Author(s): 能登舞、蓮沼直子、眞鍋求、長田真一
  • Organizer: 第110回日本皮膚科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2011-12-10
• [Presentation] 表皮の極性形成のメカニズム (2011)
  • Author(s): 長田真一、秋本和憲、大野茂男、川名誠司
  • Organizer: 第110回日本皮膚科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-10
• [Presentation] 心障害を伴ったANCA陰性Churg-Strauss症候群の2例 (2011)
  • Author(s): 長田真一
  • Organizer: 第34回皮膚脈管膠原病研究会
  • Place of Presentation: 宮日会館・宮崎市
  • Year and Date: 2011-01-21
• [Presentation] 多発性脳出血をきたしたChurg-Strauss症候群の1例 (2010)
  • Author(s): 長田真一
  • Organizer: 第33回皮膚脈管膠原病研究会
  • Place of Presentation: 文京シビックホール(東京都)
  • Year and Date: 2010-01-22
• [Presentation] Progranulin, a secreted tumorigenesis and dementia-related factor, is required for melanocyte development (2009)
  • Author(s): 長田真一、大森慎也、稲森雅子、川名誠司、平良眞規
  • Organizer: 第34回日本研究皮膚科学会
  • Place of Presentation: 京都
  • Year and Date: 2009-12-04
• [Presentation] Progranulin, a secreted tumorigenesis and dementia-related factor, is required for melanocyte development (2009)
  • Author(s): 長田真一
  • Organizer: 第34回日本研究皮膚科学会
  • Place of Presentation: JALリゾートシーホークホテル福岡 (福岡県)
  • Year and Date: 2009-12-04
• [Presentation] 経皮的血管形成術が奏功した皮膚型結節性多発動脈炎の1例 (2009)
  • Author(s): 長田真一
  • Organizer: 第61回日本皮膚科学会西部支部学術大会
  • Place of Presentation: ビーコンプラザ (大分県)
  • Year and Date: 2009-10-24
• [Presentation] Progranulin, a secreted tumorigenesis and dementia-related factor, is required for neural crest formation (2009)
  • Author(s): Osada, S., Ohmori, S., Inamori, M., Kawana, S. and Taira, M
  • Organizer: 15th Meeting of the European Society for Pigment Cell Research
  • Place of Presentation: ミュンスター(ドイツ)
  • Year and Date: 2009-09-22
• [Presentation] Progranulin, a secreted tumorigenesis and dementia-related factor, is required for neural crest formation (2009)
  • Author(s): 長田真一
  • Organizer: 15^<th> Meeting of the European Society for Pigment Cell Research
  • Place of Presentation: ミュンスター大学 (ドイツ)
  • Year and Date: 2009-09-20
• [Presentation] 多発性脳出血をきたしたChurg-Strauss症候群の1例 (2009)
  • Author(s): 長田真一
  • Organizer: 第13回関東皮膚脈管懇話会
  • Place of Presentation: 持田ホール (東京都)
  • Year and Date: 2009-09-13
• [Presentation] 鼻部脂腺癌の1例 (2009)
  • Author(s): 長田真一
  • Organizer: 第824回日本皮膚科学会東京支部地方会
  • Place of Presentation: 興和ホール (東京都)
  • Year and Date: 2009-06-20