Functional coupling between Ca^<2+> influx anf Ca^<2+> release during Ca^<2+> oscillatons in fertilized mammalian eggs
| Project/Area Number |
21590229
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | The University of Electro-Communications |
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Principal Investigator |
SHIRAKAWA Hideki 電気通信大学, 大学院・情報理工学研究科, 准教授 (40241070)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 受精 / カルシウムシグナリング / カルシウム流入 / 細胞内カルシウムイオン / カルシウム遊離 / 細胞生理学 / 発生・分化 / 細胞内カルシウム |
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| Research Abstract |
To elucidate the regulatory mechanism for Ca^<2+> influx pathway in fertilized mammalian eggs, we conducted a series of molecular and physiological experiments to interfere the interactions between Ca^<2+> influx channels on the plasma membrane, TRPC and Orai, and proteins on the ER membrane, STIM. The results suggested that, although none of these proteins participate functionally in the maintenance of the Ca^<2+> oscillations by activating Ca^<2+> influx, STIM1 may have an novel role other than as an activator of store-operated Ca^<2+> entry.
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Report
(4 results)
Research Products
(27 results)
