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Imaging analysis of phosphatidylserine-evoked initiation of coagulation cascade on activated platelets surface.

Research Project

Project/Area Number 21590230
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

URANO Tetsumei  浜松医科大学, 医学部, 教授 (50193967)

Co-Investigator(Kenkyū-buntansha) SUZUKI Yuko  浜松医科大学, 医学部, 准教授 (20345812)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords血液凝固 / 血液レオロジー / 線溶
Research Abstract

(1) Analyses of the regulatory mechanisms on PS exposure on platelets' surface and its contribution to micro-particle bearing TF-evoked activation of coagulation cascade.
Exposure of PS on platelets' surface plays essential role in thrombus formation. Based on our recent finding in in-vivo study that platelets expose PS only when they exist in the center of the thrombus, we analyzed the factors to regulate PS exposure on platelets surface. To elucidate how PS exposure is regulated within the thrombus, we analyzed PS exposure on platelets existing in fibrin network using diluted platelet-rich plasma by Confocal Laser Scanning Microscopy. Almost all platelets bound to fibrin scaffold and exposed PS after treatment with TF, thrombin or ionomycin. An attenuation of fibrin mesh formation by several pharmacological methods suppressed PS exposure. FK633, a GPIIb/IIIa antagonist, entirely inhibited fibrin(ogen) binding abrogated fibrin network formation, but also reduced PS exposure without suppressing fibrin(ogen) binding. Cytochalasin B impaired both platelets' binding to fibrin(ogen) and PS exposure. These results suggest that GPIIb/IIIa-mediated outside-in signals in platelets generated by the binding to fibrin scaffold and the associated mechanical foci, appear to be essential for PS exposure. Such regulation of platelet PS exposure may play an important role in the control of hemostasis.(submitted)
U937 cells were treated by calcium ionophore, and TF bearing microparticles were obtained. Supplementation of the TF-bearing microparticle to the system mentioned above, successfully generated fibrin network. We stared to analyze the space-and time-dependent interaction between TF bared on microparticle and PS exposed on activated platelets both of which are essential to activate coagulation cascade.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (71 results)

All 2012 2011 2010 2009 Other

All Journal Article (33 results) (of which Peer Reviewed: 10 results) Presentation (34 results) Book (4 results)

  • [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling2012

    • Author(s)
      Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, TakayamaN, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, and Nagai R
    • Journal Title

      Blood

      Volume: 119(8)

    • Related Report
      2011 Final Research Report
  • [Journal Article] PAI-1, progress in understanding the clinical problem and its aetiology2012

    • Author(s)
      Iwaki T, Urano T, Umemura K
    • Journal Title

      British Journal of Haematology

      Volume: (In press) Issue: 3 Pages: 291-8

    • DOI

      10.1111/j.1365-2141.2012.09074.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel mechanism of the expression and amplification of cell surface-associated fibrinolytic activity demonstrated by real-time imaging analysis2011

    • Author(s)
      Suzuki, Y and Urano T
    • Journal Title

      Journal Pharmacological Sciences

      Volume: 116(1) Pages: 19-24

    • Related Report
      2011 Final Research Report
  • [Journal Article] In vivo imaging analysis of the interaction between unusually large von-Willebrand factor multimers and platelets on the surface of vascular wall2011

    • Author(s)
      Rybaltowski M, Suzuki Y, Mogami H, Chlebinska I, Brzoska T, Tanaka A, Banno F, Miyata T, Urano T
    • Journal Title

      Pflugers Arch-Eur J Physiol

      Volume: 461(6) Pages: 623-633

    • Related Report
      2011 Final Research Report
  • [Journal Article] Life-threatening haemorrhage and prolonged wound healing are remarkable phenotypes manifested by complete PAI-1 deficiency in humans2011

    • Author(s)
      Iwaki T, Tanaka A, Miyawaki Y, Suzuki A, Kobayashi T, Takamatsu J, Matsushita T, Umemura K, Urano T, Kojima T, Terao T, Kanayama N
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 9(6) Pages: 1200-1206

    • Related Report
      2011 Final Research Report
  • [Journal Article] Surface-retained tPA is essential for effective fibrinolysis on vascular endothelial cells2011

    • Author(s)
      Suzuki Y, Yasui Y, Brzoska T, Mogami H, Urano T
    • Journal Title

      Blood

      Volume: 118(11) Pages: 3182-3185

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] ユーグロブリンクロット溶解時間(Euglobulin Clot Lysis Time : ECLT)2011

    • Author(s)
      浦野哲盟、柴山知子、鈴木優子
    • Journal Title

      検査と技術

      Volume: 39(2) Pages: 86-92

    • Related Report
      2011 Final Research Report
  • [Journal Article] コレステロールと抗血栓効果2011

    • Author(s)
      鈴木優子、浦野哲盟
    • Journal Title

      循環器内科

      Volume: 69(2) Pages: 170-176

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 喫煙による血栓傾向の機序について教えてください2011

    • Author(s)
      浦野哲盟
    • Journal Title

      喫煙が血栓傾向をおこす機序血栓と循環

      Volume: 19(1) Pages: 31-34

    • Related Report
      2011 Final Research Report
  • [Journal Article] 線溶系検査の意味するところ2011

    • Author(s)
      浦野哲盟, 鈴木優子
    • Journal Title

      臨床病理

      Volume: 59(7) Pages: 703-708

    • NAID

      10029615401

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 血栓形成の分子機構:凝固に伴い線溶活性が増強する機構2011

    • Author(s)
      浦野哲盟
    • Journal Title

      Thrombosis Medicine

      Volume: 1(1) Pages: 89-92

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 血栓形成の分子機構:組織因子の構造変化と凝固活性発現調節2011

    • Author(s)
      浦野哲盟
    • Journal Title

      Thrombosis Medicine

      Volume: 1(1) Pages: 89-92

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 線溶機序2011

    • Author(s)
      浦野哲盟
    • Journal Title

      脈管学

      Volume: 51(3) Pages: 293-299

    • NAID

      10029767425

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling2011

    • Author(s)
      S.Nishimura
    • Journal Title

      Blood

      Volume: 119 Issue: 8 Pages: 128-131

    • DOI

      10.1182/blood-2011-09-381400

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 「技術講座」ユーグロブリンクロット溶解時間(Euglobulin Clot Lysis Time : ECLT)2011

    • Author(s)
      浦野哲盟、柴山知子、鈴木優子
    • Journal Title

      検査と技術

      Volume: 39(2) Pages: 86-92

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 喫煙による血栓傾向の機序について教えてください 喫煙が血栓傾向をおこす機序2011

    • Author(s)
      浦野哲盟
    • Journal Title

      血栓と循環

      Volume: 19(1) Pages: 31-34

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 抗血栓療法「凝固線溶系と血栓形成」2010

    • Author(s)
      浦野哲盟, 鈴木優子
    • Journal Title

      治療学

      Volume: 44(6) Pages: 17-20

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] GFP強発現ADAMTS13遺伝子欠損マウスの生体内イメージング解析2010

    • Author(s)
      浦野哲盟, 鈴木優子, 最上秀夫, 坂野史明
    • Journal Title

      血栓と循環

      Volume: 18(2) Pages: 4-7

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Unique secretory dynamics of tissue plasminogen activator and its modulation by plasminogen activator inhibitor-1 in vascular endothelial cells2009

    • Author(s)
      Suzuki Y, Mogami H, Ihara Y, Urano T
    • Journal Title

      Blood

      Volume: 113 Pages: 470-478

    • NAID

      120005313162

    • Related Report
      2011 Final Research Report
  • [Journal Article] Involvement of platelet activation by P2Y12 receptor in the development of transplant arteriosclerosis in mice2009

    • Author(s)
      Yashiro K, Matsumoto Y, Ihara H, Suzuki Y, Kondo K, Urano T, Umemura K
    • Journal Title

      Transplantation

      Volume: 87(3) Pages: 660-667

    • Related Report
      2011 Final Research Report
  • [Journal Article] A novel phospha sugar analogue : synthesis and evaluation of 2, 3-dibromo-3-methyl-1-phenylphospholane 1-oxide as a new class of potential panti-proliterative materials for leukemia cells2009

    • Author(s)
      Fujie M, Nakamura S, Asai K, Niimi T, Yamashita J, Kiyofuji K, Shibata K, Suzuki M, Aoshima R, Urano T and Yamashita M
    • Journal Title

      Heterocyclic Communications

      Volume: 15(4) Pages: 273-278

    • Related Report
      2011 Final Research Report
  • [Journal Article] Inactivation of plasminogen activator inhibitor type 1 by activated factor XII plays a role in the enhancement of fibrinolysis by contact factors in-vitro2009

    • Author(s)
      Tanaka A, Suzuki Y, Sugihara K, Kanayama N, Urano T
    • Journal Title

      Life Scineces

      Volume: 85(5/6) Pages: 220-225

    • Related Report
      2011 Final Research Report
  • [Journal Article] Enhancement of fibrinolysis by gel-filtered platelets and its quenching by cytochalasin B and GPIIb/IIIa antagonists2009

    • Author(s)
      Hoki S, Suzuki Y, Umemura K, Urano T
    • Journal Title

      Pharmacological Reports

      Volume: 61(5) Pages: 877-84

    • Related Report
      2011 Final Research Report
  • [Journal Article] A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy and epifluorescence microscopy2009

    • Author(s)
      Adachi E, Kazoe Y, Sato Y, Suzuki Y, Urano T, Ueyama T, Saito N, Nikolaev VO, Lohse MJ, Tominaga M, Mogami H
    • Journal Title

      Pflugers Arch-Eur J Physiol

      Volume: 459(1) Pages: 227-34

    • Related Report
      2011 Final Research Report
  • [Journal Article] 血栓止血の臨床-研修医のために-2009

    • Author(s)
      浦野哲盟
    • Journal Title

      線溶療法の考え方と治療薬剤Fibrinlytic therapy : Concept & Drugs血栓止血学会雑誌

      Volume: 20(4) Pages: 398-400

    • Related Report
      2011 Final Research Report
  • [Journal Article] Involvement of platelet activation by P2Y12 receptor in the development of transplant arteriosclerosis in mice2009

    • Author(s)
      Yashiro K, Matsumoto Y, Ihara H, Suzuki Y, Kondo K, Urano T, Umemura K.
    • Journal Title

      Transplantation 87 (3)

      Pages: 660-667

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inactivation of plasminogen activator inhibitor type 1 by activated factor XII plays a role in the enhancement of fibrinolysis by contact factors in-vitro2009

    • Author(s)
      Tanaka A, Suzuki Y, Sugihara K, Kanayama N, Urano T.
    • Journal Title

      Life Scineces 85(5/6)

      Pages: 220-225

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of fibrinolysis by gel-filtered platelets and its quenching by cytochalasin B and GPIIb/IIIa antagonists2009

    • Author(s)
      Hoki S, Suzuki Y, Umemura K, Urano T.
    • Journal Title

      Pharmacological Reports 61(5)

      Pages: 877-84

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] E A technique for monitoring multiple signals with a combination of prism-based total internal reflection fluorescence microscopy and epifluorescence microscopy2009

    • Author(s)
      Adachi E, Kazoe Y, Sato Y, Suzuki Y, Urano T, Ueyama T, Saito N, Nikolaev VO, Lohse MJ, Tominaga M, Mogami H.
    • Journal Title

      Pflugers Arch-Eur J Physiol 459(1)

      Pages: 227-34

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel mechanism of the expression and amplification of cell surface-associated fibrinolytic activity demonstrated by real-time imaging analysis.

    • Author(s)
      Suzuki, Y, Urano T
    • Journal Title

      Journal Pharmacological Sciences

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging analysis of the interaction between unusually large von-Willebrand factor multimers and platelets on the surface of vascular wall.

    • Author(s)
      Rybaltowski M, Suzuki Y, Mogami H, Chlebinska I, Brzoska T, Tanaka A, Banno F, Miyata T, Urano T
    • Journal Title

      Pflugers Arch-Eur J Physiol

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Life-threatening haemorrhage and prolonged wound healing are remarkable phenotypes manifested by complete PAI-1 deficiency in humans.

    • Author(s)
      Iwaki T, Tanaka A, Miyawaki Y, Suzuki A, Kobayashi T, Takamatsu J, Matsushita T, Umemura K, Urano T, Kojima T, Terao T, Kanayama N.
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel phospha sugar analogue : synthesis and evaluation of 2,3-dibromo-3-methyl-1-phenylphospholane 1-oxide as a new class of potential panti-proliterative materials for leukemia cells

    • Author(s)
      Fujie M, Nakamura S, Asai K, Niimi T, Yamashita J, Kiyofuji K, Shibata K, Suzuki M, Aoshima R, Urano T, Yamashita M
    • Journal Title

      Heterocyclic Communications (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Unique secretory mechanism of t-PA and the expression of fibrinolytic activity on vascular endothelial cells2011

    • Author(s)
      Suzuki Y, Urano T
    • Organizer
      XXIIIth Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-07-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] ECLT shows fibrinolytic potential to be determined by the balance between tPA and PAI-1. What we learned from PAI-1 deficient patients2011

    • Author(s)
      Urano T, Suzuki Y
    • Organizer
      57th Annual Meeting of Scientific & Standardization Committee of the ISTH
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Unique secretory mechanism of tPA and expression of fibrinolytic activity on vascular endothelial cells2011

    • Author(s)
      Suzuki Y, Urano T
    • Organizer
      XXIIIth Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] ECLT shows fibrinolytic potential to be determined by the balance between tPA and PAI-1. What we learned from PAI-1 deficient patients2011

    • Author(s)
      Urano T, Suzuki Y
    • Organizer
      57th Annual Meeting of Scientific & Standardization Committee of the ISTH
    • Place of Presentation
      Kyoto Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Spontaneous plasma clot lysis time assay revealed the importance of "coagulation-associated enhancement of fibrinolysis"2011

    • Author(s)
      Urano T, Brzoska T, Suzuki Y
    • Organizer
      57th Annual Meeting of Scientific & Standardization Committee of the ISTH
    • Place of Presentation
      Kyoto Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Mogami H Real time imaging of plasminogen binding to platelet-rich micro-thrombus in vivo2011

    • Author(s)
      Urano T, Tanaka A, Suzuki Y, Brzoska T
    • Organizer
      57th Annual Meeting of Scientific & Standardization Committee of the ISTH
    • Place of Presentation
      Kyoto Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Imaging analysis of the interaction between unusually large von-willebrand factor multimers and platelets on vascular endothelial cells in living animals2011

    • Author(s)
      Brzoska T, Rybaltowski M, Suzuki Y, Mogami H, Chlebinska I, Tanaka A, Banno F, Miyata T, Urano T
    • Organizer
      57th Annual Meeting of Scientific & Standardization Committee of the ISTH
    • Place of Presentation
      Kyoto Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] PAI-1 deficiency in humans and mice2011

    • Author(s)
      T.Iwaki, T.Kobayashi, K.Umemura, T.Urano, T.Kojima, N.Knayama
    • Organizer
      XXIIIth Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spontaneous plasma clot lysis time assay revealed the importance of "coagulation-associated enhancement of fibrinolysis"2011

    • Author(s)
      Urano T, Brzoska T, Suzuki Y
    • Organizer
      XXIIIth Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Annual Research Report
  • [Presentation] Imaging analysis of the interaction between unusually large von-willebr and factor multimers and platelets on vascular endothelial cells in living animals2011

    • Author(s)
      Brzoska T, Rybaltowski M, Suzuki Y, Mogami H, Chlebinska I, Tanaka A, Banno F, Miyata T, Urano T
    • Organizer
      XXIIIth Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Annual Research Report
  • [Presentation] Real time imaging of plasminogen binding to platelet-rich micro-thrombus in vivo2011

    • Author(s)
      Urano T, Tanaka A, Suzuki Y, Brzoska T, Mogami H
    • Organizer
      XXIIIth Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血管内皮細胞表面における線溶酵素活性発現-増幅機構2011

    • Author(s)
      浦野哲盟, 鈴木優子
    • Organizer
      第16回日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      大阪千里ライフサイエンスセンター
    • Related Report
      2011 Annual Research Report
  • [Presentation] Real time imaging of plasminogen binding to micro-thrombus in vivo2011

    • Author(s)
      Urano T, Tanaka A, Brzoska T, Mogami H, Suzuki Y
    • Organizer
      第19回血管生物医学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Membrane-retained secreted tPA triggers cell-associated fibrinolysis on vascular endothelial cells.血管内皮細胞における細胞表面滞留tPAによる新たな細胞表面線溶活性発現調節機構2011

    • Author(s)
      Urano T, Suzuki Y
    • Organizer
      第89回日本生理学会
    • Place of Presentation
      松本
    • Related Report
      2011 Annual Research Report
  • [Presentation] 血栓溶解療法:安全域と治療域の分子指標2010

    • Author(s)
      浦野哲盟, 鈴木優子
    • Organizer
      第5回 日本血栓止血学会 学術標準化委員会シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] In-vivo Imaging Analyses of Platelet Thrombus Formation2010

    • Author(s)
      T.Urano, Y.Suzuki, H.Mogami
    • Organizer
      The 6th Congress of Asia Pacific Society on Thrombosis and Haemostasis
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2010-10-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 線溶系検査の意味するところ2010

    • Author(s)
      浦野哲盟, 鈴木優子
    • Organizer
      第57回 日本臨床検査医学会学術集会
    • Place of Presentation
      京王プラザ
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Intra-vital analyses of plasminogen binding to platelet-rich micro-thrombus2010

    • Author(s)
      A.Tanaka, Y.Suzuki, T.Urano
    • Organizer
      20th International Congress on Fibrinolysis and Proteolysis
    • Place of Presentation
      Boston
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血栓形成機構の生体内イメージング解析2010

    • Author(s)
      浦野哲盟
    • Organizer
      第122回 日本薬理学会関東支部会
    • Place of Presentation
      静岡県立大学
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Global Fibrinoolysis Assays2010

    • Author(s)
      Urano T
    • Organizer
      56th Annual Meeting of the Scientific and Standardization Connnitttee of the ISTH (SSC2010)
    • Place of Presentation
      Cairo
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体内顕微鏡を用いた微小局在血栓へのプラスミノーゲンの集積の解析2010

    • Author(s)
      田中晶, 鈴木優子, 浦野哲盟
    • Organizer
      第33回 日本血栓止血学会学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-04-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Global fibrinolysis assay2010

    • Author(s)
      Urano T
    • Organizer
      56th Annual Meeting of the Scientific and Standardization Committtee of the ISTH(SSC2010)
    • Place of Presentation
      Cairo(Egypt)
    • Related Report
      2011 Final Research Report
  • [Presentation] Intra-vital analyses of plasminogen binding to platelet-rich micro-thrombus2010

    • Author(s)
      Tanaka A, Suzuki Y, Urano T
    • Organizer
      20th International Congress on Fibrinolysis and Proteolysis
    • Place of Presentation
      Amsterdam(The Netherlands)
    • Related Report
      2011 Final Research Report
  • [Presentation] In-vivo Imaging Analyses of Platelet Thrombus Formation2010

    • Author(s)
      Urano T, Suzuki Y, Mogami H
    • Organizer
      The 6th Congress of Asia Pacific Society on Thrombosis and Haemostasis
    • Place of Presentation
      Bali(Indonesia)
    • Related Report
      2011 Final Research Report
  • [Presentation] Realtime imaging analysis of phosphatidylserine exposure on platelet thrombus using intra-vital confocal microscopy2009

    • Author(s)
      T.Urano, M.Rybaltowski, T.Hayashi, Y.Suzuki, H.Mogami
    • Organizer
      XXIIth Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Boston (USA)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Inactivation of PAI-1 by activated Factor XII plays a role in the contact phase dependent enhancement of fibrinolysis2009

    • Author(s)
      A.Tanaka, Y.Suzuki, N.Kanayama, T.Urano
    • Organizer
      XXIIth Congress of the International Society on Thrombosis and Haemostasis
    • Place of Presentation
      Boston (USA)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管内皮細胞における線溶活性化因子分泌動態のイメージング解析2009

    • Author(s)
      鈴木優子, 浦野哲盟
    • Organizer
      第56回中部日本生理学会
    • Place of Presentation
      石川県立音楽堂 (金沢)
    • Related Report
      2009 Annual Research Report
  • [Presentation] Secretagogue-induced multiple signal cross-talk in insuline secreting cells2009

    • Author(s)
      H.Mogami, E.Adachi, I.Kojima, N.Saito, Y.Suzuki, T.Urano
    • Organizer
      the XXXVI International Congress of Physiological Sciences (IUPS2009)
    • Place of Presentation
      Kyoto
    • Related Report
      2009 Annual Research Report
  • [Presentation] Unique secretory dynamics of tissue plasminogen activator and its mod ulation by plasminogen activator inhibitor-1 in vascular endothelial cells. ISTH2011 Memorial Award2009

    • Author(s)
      鈴木優子, 浦野哲盟
    • Organizer
      第32回 日本血栓止血学会学術集会
    • Place of Presentation
      北九州国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] Intra-vital imaging analysis of platelet adhesion to vascular wall in AD AMTS13 KO mice2009

    • Author(s)
      Rybaltowski Miroslaw, 鈴木優子, 田中晶, 坂野史明, 宮田敏行, 浦野哲盟
    • Organizer
      第32回 日本血栓止血学会学術集会
    • Place of Presentation
      北九州国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血漿溶解時間を用いた凝固に伴う線溶活性増強作用の解析2009

    • Author(s)
      浦野哲盟, 田中晶, 鈴木優子
    • Organizer
      第32回 日本血栓止血学会学術集会
    • Place of Presentation
      北九州国際会議場
    • Related Report
      2009 Annual Research Report
  • [Presentation] 線溶系検査の意味するところ

    • Author(s)
      浦野哲盟,鈴木優子
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Related Report
      2011 Final Research Report
  • [Presentation] 血栓溶解療法:安全域と治療域の分子指標

    • Author(s)
      浦野哲盟,鈴木優子
    • Organizer
      第5回日本血栓止血学会学術標準化委員会シンポジウム
    • Related Report
      2011 Final Research Report
  • [Presentation] 生体内顕微鏡による微小血栓形成とプラスミノーゲン集積の解析

    • Author(s)
      浦野哲盟, 田中晶, トーマスブルゾスカ, 鈴木優子, 最上秀夫
    • Organizer
      第88回 日本生理学会大会
    • Place of Presentation
      震災により誌上開催
    • Related Report
      2010 Annual Research Report
  • [Book] 「血栓溶解薬」In抗血栓薬の最前線-基礎と臨床-(編者齊藤英彦)2011

    • Author(s)
      浦野哲盟
    • Publisher
      医薬ジャーナル社
    • Related Report
      2011 Annual Research Report
  • [Book] 抗血栓薬の最前線-基礎と臨床-2011

    • Author(s)
      浦野哲盟(分担)
    • Total Pages
      315
    • Publisher
      医薬ジャーナル
    • Related Report
      2010 Annual Research Report
  • [Book] 動脈硬化/血栓性疾患ハンドブック (後藤信哉編)2009

    • Author(s)
      浦野哲盟
    • Total Pages
      192
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2009 Annual Research Report
  • [Book] PAI-1, progress in understanding the clinical problem and its aetiology.British journal of haematology

    • Author(s)
      Iwaki T, Urano T and Umemura K
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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