Insulin secretion in pancreaticβcells and control of blood glucose level studied by fiber-coupled micro endoscopy
| Project/Area Number |
21590231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Toyohashi University of Technology (2011)
Hamamatsu University School of Medicine (2009-2010) |
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Principal Investigator |
SAKURAI Takashi 豊橋技術科学大学, エレクトロニクス先端融合研究所, 特任准教授 (50283362)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 生理学 / 細胞・組織 / 生体・分子 / 糖尿病 / バイオ関連機器 |
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| Research Abstract |
To elucidate physiological functions of multiple cells or organs exsising deep inside body, we developed a branch-type fiber-coupled confocal microscope(FCM). The spatio-temporal performance of FCM was enough to resolve the fluorescently-labelled granules in the pancreaticβcells. By using FCM, we could measure glucose-dependent fluorescent intensity changes in theβ-granules reflecting secretion of insulin to the blood stream. The FCM may be usefull technique for the understanding of mechanisms or disorders controlling of the blood glucose level.
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Report
(4 results)
Research Products
(11 results)
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[Presentation] 生き物を見る技術2010
Author(s)
櫻井孝司
Organizer
京都工業繊維大学イメージング講習会
Place of Presentation
京都工業繊維大学
Year and Date
2010-09-14
Related Report
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