Structure-function studies of voltage-sensors and cAMP-dependent activation in HCN channels
| Project/Area Number |
21590232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Kyoto University |
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Principal Investigator |
ISHII Takahiro 京都大学, 大学院・医学研究科, 研究員 (40303812)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | チャネル / 過分極 / cAMP / HCN / Ih / 電位センサー / 変異体 / ペースメーカー / システイン残基 / 点変異 |
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| Research Abstract |
HCN channels are widely expressed in various tissues, and play important roles in pacemaker and cell excitability. HCN channels are slowly activated by hyperpolarization and by cAMP. This study elucidated the molecular basis of these characteristics in HCN channels.
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Report
(4 results)
Research Products
(12 results)
