Studies on the mechanism of epithelial ion transport mediated by Chemical receptors expressed in the colonic mucosa
| Project/Area Number |
21590235
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | University of Shizuoka |
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Principal Investigator |
KUWAHARA Atsukazu 静岡県立大学, 大学院・環境科学研究所, 教授 (60142890)
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| Co-Investigator(Kenkyū-buntansha) |
KARAKI Shinichiro 静岡県立大学, 環境科学研究所, 助教 (00363903)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 消化管 / 化学受容細胞 / L型腸内分泌細胞 / プロスタグランジン / 短鎖脂肪酸受容体 / 苦味受容体 / 匂い受容体 / TRPA1チャネル / 食物繊維 |
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| Research Abstract |
Gut lumen is continually exposed to many agents, including noxious compounds. Chemical receptors that detect the luminal environment are thought to play an important role as sensors and as modulators of epithelial cell functions. In the present research, function of chemical sensors in the rat and human large intestine were investigated.
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Report
(4 results)
Research Products
(51 results)
