| Project/Area Number |
21590238
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Nagoya City University |
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Principal Investigator |
UEDA Takashi 名古屋市立大学, 大学院・医学研究科, 准教授 (90244540)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Shoichi 大阪大学, 大学院・医学系研究科, 教授 (20216063)
UGAWA Shinya 名古屋市立大学, 大学院・医学研究科, 教授 (20326135)
ISHIDA Yusuke 大阪大学, 大学院・医学系研究科, 講師 (30381809)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMADA Shoichi 大阪大学, 大学院・医学系研究科, 教授 (20216063)
ISHIDA Yusuke 大阪大学, 大学院・医学系研究科, 講師 (30381809)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 受容体 / 細胞内シグナル伝達 / 化学感覚 / 化学受容器 / シグナル伝達 / 呼吸器系 / 上皮細胞 / 嗅覚系CO_2受容器 / 嗅覚系CO2受容機 / 嗅覚系CO2受容機構 |
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| Research Abstract |
Mouse nasal epithelial cells partially exhibited CO_2-induced intracellular calcium mobilization. These cells did not respond to the ligands that activate proton-sensitive cation channels, such as transient receptor potential vanilloid 1(TRPV1), acid-sensing ion channel(ASIC) 1a, ASIC1b, ASIC2a, ASIC2b and ASIC3.Since the nasal epithelial cells responded to NaHCO_3 solution rather than acidic pH solution, a mechanism for detection of HCO_3-may be involved in nasal CO_2 perception.
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