| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Research Abstract |
To gain insight into structure-function relationship of Kv channel and other physiological issues, molecular dynamics(MD) simulations were conducted. Atomistic details regarding Kv channel closing mechanism were revealed. We also applied coarse-grained MD simulations to curved membranes, in particular, hemifusion-mimicking membrane systems. The latter analysis showed that lipids with a high degree of negative spontaneous curvature tend to be enriched at the junction of the bilayers that is highly curved. We also showed that cholesterol-dependent formation of lipid microdomains proceeds under strong influence of membrane curvature. The possibility that such curvature dependent localization of microdomains may contribute to the intracellular lipid sorting was discussed.
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