The Regulation and Pathophysiology of Intracellular Water Metabolism by an Intracellular Aquaporin
Project/Area Number |
21590242
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General physiology
|
Research Institution | Meiji Pharmaceutical University |
Principal Investigator |
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 水チャネル / 多発性嚢胞腎 / 細胞内 / 小胞体 / 血液脳関門 / ノックアウトマウス / 脳浮腫 / 胸腺 / 浸透圧 / 肝障害 / 腎障害 / 精子形成 / 内皮細胞 / アクアポリン / 脈絡叢 / 敗血症 / 水輸送 / 嚢胞腎 / 細胞内オルガネラ / マイクロアレイ / 2次元蛋白電気泳動 |
Research Abstract |
This study revealed the importance of endoplasmic reticulum(ER) stress reaction induced by the accumulation of unfold proteins in the ER for the development of polycystic kidneys in AQP11 null mice by comprehensive gene and protein expression surveys of the kidney. Other than the kidney, AQP11 plays some roles in the liver, testis, thymus and brain. It is noteworthy that AQP11 is expressed at the endothelium of cerebral capillaries seemingly for the adaptation of osmotic stresses in the brain.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] The NPC motif of aquaporin-11, unlike the NPA motif of known aquaporins, is essential for full expression of molecular function2011
Author(s)
Ikeda M, Andoo A, Shimono M, Takamatsu N, Taki A, Muta K, Matsushita W, Uechi T, Matsuzaki T, Kenmochi N, Takata K, Sasaki S, Ito K, Ishibashi K.
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Journal Title
J Biol Chem
Volume: 286
Issue: 5
Pages: 3342-3350
DOI
Related Report
Peer Reviewed
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