Regulation of ciliary beat frequency by sex hormones in ciliary cells of Fallopian tube.
| Project/Area Number |
21590243
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Fallopian tube / cilia / ciliary beat frequency / estrogen / progesterone / egg transport / ovarian cycle / oviduct epithelia / oviduct cilia / Egg transport / egg trans / infertilization / Ciliary beat frequency |
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| Research Abstract |
The ciliary beat frequency(CBF) of guinea pig fimbria during the ovarian cycle was measured by video microscopy using a high-speed camera(500Hz). A moderate increase in estrogen concentration, [βE_2], maintains a high CBF(15.5Hz) during the ovulation and then a further increase in [βE_2] decreases CBF(13.5 Hz) in the ovulatory phase. In the early and late luteal phase, low [βE_2] and progesterone concentration, [PRG], increase CBF to 17Hz and 15Hz, respectively, and in the middle luteal phase, a high [PRG] decreases CBF(～ 12Hz). Thus, the CBF of the fimbria was controlled by signals via βE_2 and PRG receptors in guinea pigs. Moreover both βE_2 and PRG antagonized each other in CBf regulation, that is βE_2 inhibits PRG actions and contrary, PRG inhibits βE_2 actions.
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Report
(4 results)
Research Products
(30 results)
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Author(s)
Marunaka Y, Niisato N, Taruno A, Ohta M, Miyazaki H, Hosogi S, Nakajima K, Kusuzaki K, Ashihara E, Nishio K, Iwasaki Y, Nakahari T, Kubota T
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Journal Title
J Biomed Biotechnol
Volume: 2011
Issue: 1
Pages: 978196-978196
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Kosuga T, Shiozaki A, Ichikawa D, Fujiwara H, Komatsu S, Iitaka D, Tsujiura M, Morimura R, Takeshita H, Nagata H, Okamoto K, Nakahari T, Marunaka Y, Otsuji T
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Iitaka D, Shiozaki A, Ichikawa D, Kosuga T, Komatsu S, Okamoto K, Fujiwara H, Ishii H, Nakahari T, Marunaka Y, Otsuji E
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Journal Title
J Surg Res
Volume: 176
Issue: 2
Pages: 524-34
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[Journal Article] Ciliary beat frequency controlled by estradiol and progesterone during ovarian cycle in guinea pig Fallopian tube2010
Author(s)
A Nishimura, K Sakuma, C Shimamoto, S Ito, T Nakano, E Daikoku, M Ohmichi, T Ushiroyama, M Ueki, H Kuwabara, H Mori, T Nakahari
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Journal Title
Exp. Physiol
Volume: 95
Pages: 819-828
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