Analysis of the network for the vocalization-respiration mode switching mechanism
| Project/Area Number |
21590245
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
ARATA Akiko 兵庫医科大学, 医学部, 准教授 (00266082)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 橋結合腕傍核 / 吸息-呼息切り替え機構 / NMDA / GABA / 新生ラット / NMDAレセプター / 随意運動 / 能動的吸息-呼息切り替え / 呼吸性ニューロン |
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| Research Abstract |
The nucleus parabrachialis(NPB) is known as a respiratory modulating center and the NPB receives direct inputs from the vocal and insular cortices associated with the higher processing of emotion and speech. We examined how the NPB participates in the inspiratory-expiratory phase switching using brainstem-spinal cord preparations obtained from 0-4-day-old rats. The NPB electrical stimulation induced a transient depression or termination in the C4 inspiratory phase. This inhibition of C4 was greatly reduced by perfusion of NMDA antagonists and was blocked by GABAA-antagonist. We identified inspiratory-expiratory(I-E) neurons that responded vagal stimulation in the NPB. These I-E neurons which might be inspiratory off-switch neurons received the inputs from the para-facial respiratory group and adrenergic modulation. These results suggested that the NPB is involved in the inspiratory-expiratory phase switching in neonatal rat ; NPB might be working as a phase and/or mode switching system.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] DSCAM deficiency causes loss of pre-inspiratory neuron synchroneity and perinatal death2009
Author(s)
Amano K, Fujii M, Arata S, Tojima T, Ogawa M, Morita N, Shimohata A, Furuichi T, Itohara S, Kamiguchi H, Korenberg JR, Arata A, Yamakawa K.
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Journal Title
J Neurosci
Volume: 29
Pages: 2984-96
Related Report
Peer Reviewed
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