On the mechanism of modal regulation of cardiovascular Ca2+entry channel TRPC6
| Project/Area Number |
21590246
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Fukuoka University |
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Principal Investigator |
INOUE Ryuji 福岡大学, 医学部, 教授 (30232573)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Ca^<2+>チャネル / TRP蛋白質 / リン酸化 / 受容体・機械刺激 / 形質転換 / 活性化モード / 細胞骨格 / 蛋白質間相互作用 / 受容体刺激 / 機械刺激 / 腎疾患遺伝子変異 / 受容体機械刺激 |
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| Research Abstract |
The canonical transient receptor potential protein 6(TRPC6) is a Ca^<2+> entry channel activated by synergistic operation of receptor-mediated and mechanosentive signaling pathways. Its excessive activity contributes to the pathogenesis of cardiovascular diseases. The results of the present study suggest that the synergy between receptor and mechanical stimulations on TRPC6 channel activation likely occurs through physical interaction and functional coupling between TRPC6 channel N-terminal ankyrin-like domains and actin cytoskeleton. Further, this synergy is exaggerated by pathogenic mutations in amino acid residues adjacent to these domains, and counteracted byprotein kinase G-mediated phosphorylation of TRPC6 N-terminus, by strengthening and disrupting the N-terminus domain-actin cytoskeleton interaction, respectively.
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Report
(4 results)
Research Products
(99 results)
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[Journal Article] Protein kinase A-mediated phosphorylation of TRPC6 channels underlies suppression of angiotensin II-induced vasoconstriction2011
Author(s)
Nishioka K, Nishida M, Ariyoshi M, Saiki S, Jian Z, Hirano M, Nakaya M, Sato Y, Kita S, Iwamoto T, Hirano K, Inoue R, Kurose H
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Journal Title
Arterioscler.Thromb.Vasc.Biol.
Volume: 31
Issue: 10
Pages: 2278-2286
DOI
Related Report
Peer Reviewed
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[Journal Article] Dual Signaling Pathways of Arterial Constriction by Extracellular Uridine 5'-Triphosphate in the Rat2011
Author(s)
Sugihara M, Morita H, Matsuda M, Umebayashi H, Kajioka S, Ito S, Nishida M, Inoue R, Futatsuki T, Yamazaki J, Mori Y, Inoue R, Ito Y, Abe K, Hirata M
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Journal Title
Journal of Pharmacological Sciences
Volume: 115
Issue: 3
Pages: 293-308
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed
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[Journal Article] Dual signaling pathways of arterial constriction by extracellular UTPin the rat.2011
Author(s)
Sugihara M, Morita H, Matsuda M, Umebayashi H, Kajioka S, Ito S, Nishida M, Inoue R, Futatsuki T, Yamazaki J, Mori Y, Inoue R, Ito Y, Abe K, Hirata M.
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Journal Title
Journal of Pharmacological Sciences
Volume: 115(3)
Pages: 293-308
Related Report
Peer Reviewed
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[Journal Article] Inhibition of TRPC6 channel activity contributes to the anti-hypertrophic effects of natriuretic peptides-guanylyl cyclase-Asignaling in the heart2010
Author(s)
Kinoshita H, Kuwahara K, Nishida M, Jiang Z, Rong X, Kiyonaka S, Kuwabara Y, Kurose H, Inoue R, Mori Y, Li Y, Nakagawa Y, Usami S, Fujiwara M, Yamada Y, Minami T, Ueshima K & Nakao K
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Journal Title
Circ. Res.
Volume: 106
Issue: 12
Pages: 1849-1860
DOI
Related Report
Peer Reviewed
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[Journal Article] Ca^<2+> Influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells.2010
Author(s)
Numaga T, Nishida M, Kiyonaka S, Kato K, Katano M, Mori E, Kurosaki E, Inoue R, Hikida M, Putney, Jr, JW, Mori Y
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Journal Title
Journal of Cell Science
Volume: 123(6)
Pages: 927-938
Related Report
Peer Reviewed
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[Journal Article] Inhibition of TRPC6 channel activity contributes to the anti-hypertrophic effects of natriuretic peptides-guanylyl cyclase-Asignaling in the heart.2010
Author(s)
Kinoshita H, Kuwahara K, Nishida M, Jian Z, Rong X, Kiyonaka S, Kuwabara Y, Kurose H, Inoue R, Mori Y, Li Y, Nakagawa Y, Usami S, Fujiwara M, Yamada Y, Minami T, Ueshima K, Nakao K
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Journal Title
Circulation Research
Volume: 106(12)
Pages: 1849-1860
Related Report
Peer Reviewed
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[Journal Article] Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via PLC/diacylglycerol and PLA2/ω-hydroxylase/20-HETE pathways2009
Author(s)
Inoue R, Jensen LJ, Jian Z, Shi J, Hai L, Lurie AI, Henriksen FH, Salmonsson M, Morita H, Kawarabayashi Y, Mori M, Mori Y, Ito Y.
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Journal Title
Circ Res
Volume: 104
Pages: 1399-1409
Related Report
Peer Reviewed
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