| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
T-type voltage-gated Ca^<2+> channels have unique electrophysiological properties, which have been assumed to be suitable for physiological action such as controlling the proliferation of various tumor cells. A study of T-type voltage-gated Ca^<2+> channels on tumor development was carried on MCF-7(Human breast adenocarcinoma) cells. Cav3.1, an isoform of T-type channels, inhibited cell proliferation and induced apoptosis, while a different isoform, Cav3.2, had no effect. These suggest that the Cav3.1 channel may act as a tumor suppressor.
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