Novel role of neuronal Ca^<2+> sensor-1 as a regulator of cardiac function
Project/Area Number |
21590248
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General physiology
|
Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
NISHITANI Tomoe 独立行政法人国立循環器病研究センター, 分子生理部, 室長 (50393244)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 分子・細胞生理学 / カルシウム / 心臓 / カルシウムセンサー / 幼若期 / EC-カップリング / 心肥大 / シグナル伝達 / 幼弱期 / EC-coupling |
Research Abstract |
Intracellular Ca^<2+> plays key roles in regulating excitation-contraction coupling(EC) and hypertrophy in the heart. In the immature heart, the structure and function of sarcoplasmic reticulum(SR) is immature ; nonetheless, it is considered a primary source of Ca^<2+> for contraction, suggesting the existence of missing factors that promote SR-dependent EC coupling. We showed that neuronal Ca^<2+> sensor-1(NCS-1), a small Ca^<2+> binding protein, which functions in the heart were unknown, is one such regulator that enhances Ca^<2+> signals and contraction in the immature heart. In addition, NCS-1 expression increases in the early stages of hypertrophy in the adult heart and promotes progression of hypertrophy.
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Report
(4 results)
Research Products
(34 results)