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On the role of amygdala in emotional response during REM sleep

Research Project

Project/Area Number 21590250
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionFukushima University

Principal Investigator

KOYAMA Yoshimasa  福島大学, 共生システム理工学類, 教授 (80183812)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脳・神経 / レム睡眠 / 自律神経系 / 情動 / 夢 / 扁桃体 / 徐波睡眠 / ラット
Research Abstract

More than half of the neurons in the amygdala showed higher activity during REM sleep than during other stages (wakefulness and slow wave sleep). These neurons did not fire continuously through REM sleep, but showed phasic or burstic firing at some restricted period of REM sleep. Some of the amygdala neurons displayed firing in synchronous with large fluctuations of blood pressure. These results suggest that the amygdala have crucial roles in the changes of autonomic nervous system occurring during REM sleep, which would be closely related with emotional changes during REM sleep.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (49 results)

All 2012 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (36 results) Book (2 results) Remarks (3 results)

  • [Journal Article] Acupuncture of the sacral segment suppresses bladder activity and bladder activity-related neurons in the brainstem micturition center2012

    • Author(s)
      Wang H, Tanaka H, Kawauchi A, Miki T, Kayama Y and Koyama Y
    • Journal Title

      Neuroscience Research

      Volume: 72 Pages: 43-49

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acupuncture of the sacral segment suppresses bladder activity and bladder activity-related neurons in the brainstem micturition center2012

    • Author(s)
      Wang H., 他4名, Koyama Y.
    • Journal Title

      Neurosceince Reasarch

      Volume: 72 Pages: 43-49

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the lateral preoptic area and the bed nucleus of stria terminalis in the regulation of penile erection2010

    • Author(s)
      Hiroshi Iwasaki, Eiichi Jodo, Akihiro Kawauchi, Tsuneharu Miki, Yukihiko Kayama , Yoshimasa Koyama
    • Journal Title

      Brain Res

      Volume: 1357 Pages: 70-78

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of the lateral preoptic area and the bed nucleus of stria terminalis in the regulation of penile erection2010

    • Author(s)
      Iwasaki H., 他4名, Koyama Y.
    • Journal Title

      Brain Research

      Volume: 1357 Pages: 70-78

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳幹網様体(覚醒とレム睡眠の中枢)2009

    • Author(s)
      小山純正
    • Journal Title

      Clinical Neuroscience

      Volume: 27 Pages: 1376-1379

    • Related Report
      2011 Final Research Report
  • [Journal Article] 脳幹網様体(覚醒とレム睡眠の中枢)2009

    • Author(s)
      小山純正
    • Journal Title

      Clinical Neuroscience 27

      Pages: 1376-1379

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 視床下部と睡眠2009

    • Author(s)
      小山純正
    • Journal Title

      睡眠学(日本睡眠学会編)

      Pages: 33-40

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 睡眠覚醒ニューロン活動の記録法2009

    • Author(s)
      小山純正
    • Journal Title

      睡眠学(日本睡眠学会編)

      Pages: 313-318

    • Related Report
      2009 Annual Research Report
  • [Presentation] 扁桃体ニューロンにより睡眠中に生じる大きな血圧変動2012

    • Author(s)
      外舘圭一,松田翔平,青柳俊史,豊巻知史,辛島彰洋,小山純正
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] オレキシン神経欠損マウスにおける青斑核ノルアドレナリン神経活動変化2012

    • Author(s)
      辻野なつ子, 常松友美, 山中章弘, 小山純正, 櫻井武
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] REM sleep regulation in the Amygdala2012

    • Author(s)
      小山純正
    • Organizer
      脳・肝インターフェイスメディシン研究センターシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-03-18
    • Related Report
      2011 Final Research Report
  • [Presentation] REM sleep regulation in the Amygdala2012

    • Author(s)
      小山純正
    • Organizer
      脳・肝インターファイスデディシン研究センターシンポジウム
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2012-03-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Firing properties of the neurons in the amygdala during sleep and wakefulness in rats2011

    • Author(s)
      Koyama Y
    • Organizer
      Worldsleep 2011(Abstract Symposium)
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] Firing properties of the neurons in the amygdala during sleep and wakefulness in rats2011

    • Author(s)
      Koyama Y.
    • Organizer
      Worldsleep2011
    • Place of Presentation
      京都
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Firing properties of the neurons in the amygdala during sleep and wakefulness in rats2011

    • Author(s)
      Aoyagi T., Toyomaki T., Koyama Y
    • Organizer
      Worldsleep 2011
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-10-19
    • Related Report
      2011 Final Research Report
  • [Presentation] On the neuronal regulation of sleep-wakefulness-Neurophysiological approaches2011

    • Author(s)
      Koyama Y
    • Organizer
      Worldsleep 2011(Educational Symposium)
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-10-17
    • Related Report
      2011 Final Research Report
  • [Presentation] On the neuronal regulation of sleep-wakefulness-Neurophysiological-approaches-. (Educational Symposium)2011

    • Author(s)
      Koyama Y.
    • Organizer
      Worldsleep2011
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2011-10-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Burstic eye movements during paladoxical sleep were not under the control of superior colliculus2011

    • Author(s)
      Ogawa K., Takahashi K., Saito N., Kitahama K., Yamazaki K., Koyama Y.
    • Organizer
      Worldsleep2011
    • Place of Presentation
      京都
    • Year and Date
      2011-10-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] レム睡眠中のラット扁桃体ニューロンの相動的活動2011

    • Author(s)
      小山純正,青柳俊史,豊巻知史
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ナルコレプシーモデルマウスにおけるノルアドレナリン神経活動の変化2011

    • Author(s)
      辻野なつ子, 常松友美, 山中章弘, 小山純正, 櫻井武
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多点電極で探るラット脳幹の睡眠調節ニューロンのふるまい2011

    • Author(s)
      小山純正
    • Organizer
      包括型脳科学研究推進支援ネットワーク夏のワークショップ
    • Place of Presentation
      神戸
    • Year and Date
      2011-08-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット扁桃体ニューロンの睡眠・覚醒サイクルにおける発火様式2011

    • Author(s)
      青柳俊史, 豊智史, 伊藤晃, 小山純正
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      紙上開催
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウスにおける脳幹のアセチルコリンニューロンと非アセチルコリンニューロンによるレム睡眠の調節2011

    • Author(s)
      伊藤晃, 池田聡幸, 高橋和巳, 小山純正
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      紙上開催
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラット扁桃体ニューロンの睡眠・覚醒サイクルにおける発火様式2011

    • Author(s)
      青柳俊史,豊巻智史,伊藤晃,小山純正
    • Organizer
      88回日本生理学会大会
    • Related Report
      2011 Final Research Report
  • [Presentation] マウスにおける脳幹のアセチルコリンニューロンと非アセチルコリンニューロンによるレム睡眠の調節2011

    • Author(s)
      伊藤晃,池田聡幸,高橋和巳,小山純正
    • Organizer
      88回日本生理学会大会プログラム
    • Related Report
      2011 Final Research Report
  • [Presentation] 健やかな睡眠と覚醒のための脳のしくみ2010

    • Author(s)
      小山純正
    • Organizer
      第4回福島睡眠懇話会
    • Place of Presentation
      福島(招待講演)
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 睡眠の調節機構2010

    • Author(s)
      小山純正
    • Organizer
      第26回不眠研究会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Suppression of bladder activity by acupuncture to the sacral segment is mediated through GABAergic system2010

    • Author(s)
      Y.KOYAMA, H.WANG, Y.TANAKA, A.KAWAUCHI, T.MIKI, Y.KAYAMA
    • Organizer
      The 40th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 仙髄鍼刺激による排尿機能抑制はGABA作動性ニューロンを介している2010

    • Author(s)
      小山純正, 王慧, 田中善之, 河内明宏, 三木恒治, 香山雪彦
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] オレキシン神経欠損マウスにおけるノルアドレナリン神経活動の解析2010

    • Author(s)
      辻野なつ子, 常松友美, 山中章弘, 小山純正, 櫻井武
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      岩手
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] オレキシンニューロンによる脚橋被蓋核でのGABA放出2010

    • Author(s)
      小山純正, 高橋和巳, 斎藤直樹, 石田雄太, 本多芳子, 児玉亨
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      岩手
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳幹のアセチルコリン作動性ニューロンと非アセチルコリン作動性ニューロンのレム睡眠における活動様式について2010

    • Author(s)
      伊藤晃,高橋和巳,小山純正
    • Organizer
      第43回東北生理談話会
    • Place of Presentation
      秋田
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 扁桃体ニューロンの睡眠・覚醒サイクルにおける活動2010

    • Author(s)
      青柳俊史,豊巻智史,伊藤晃,小山純正
    • Organizer
      日本睡眠学会第35回定期学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Tonic and phasic regulations of muscular tonus through the hypothalamus2009

    • Author(s)
      小山純正
    • Organizer
      3rd International Symposium on Mobiligence
    • Place of Presentation
      淡路夢舞台国際会議場(淡路市)
    • Year and Date
      2009-11-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] Inhibition of burstic eye movements during paradoxical sleep after superior colliculus lesion2009

    • Author(s)
      小川景子, 他
    • Organizer
      6th Congress of Asian Sleep Research Society
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] GABA release from the sunstantia nigra pars reticulata and the pedunculopontine tegmental nucleus is facilitated by orexin2009

    • Author(s)
      小山純正
    • Organizer
      6th Congress of Asian Sleep Research Society
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of the superior colliculus lesions upon rapid eye movements during paradoxical sleep in the rat2009

    • Author(s)
      小川景子, 他
    • Organizer
      39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Orexin facilitates GABA release from the sunstantia nigra pars reticulata and the pedunculopontine tegmental nucleus that regulate muscular tonus2009

    • Author(s)
      K.Takahashi, et al.
    • Organizer
      39th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] オレキシン神経欠損マウスにおけるモノアミン神経活動の変化2009

    • Author(s)
      辻野なつ子, 他
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 上丘破壊によるラット逆説睡眠中の急速眼球運動の抑制2009

    • Author(s)
      小川景子, 他
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳幹のアセチルコリン作動性ニューロンとレム睡眠-脚橋被蓋核で夢を見る?-2009

    • Author(s)
      小山純正
    • Organizer
      第24回大脳基底核研究会(教育講演)
    • Place of Presentation
      丸紅多摩センター(八王子市)
    • Year and Date
      2009-08-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳幹のアセチルコリン作動性ニューロンとレム睡眠-脚橋被蓋核で夢を見る?2009

    • Author(s)
      小山純正
    • Organizer
      第24回大脳基底核研究会(教育講演)
    • Place of Presentation
      八王子
    • Year and Date
      2009-08-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Alterations in monoaminergic neurons in orexin neuron-ablated mice2009

    • Author(s)
      辻野なつ子, 他
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      京都国際会議所(京都市)
    • Year and Date
      2009-08-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Hypothalamic regulation of muscular tonus through the orexinergic and non-orexinergic systems2009

    • Author(s)
      小山純正, 他
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      京都国際会議所(京都市)
    • Year and Date
      2009-07-31
    • Related Report
      2009 Annual Research Report
  • [Book] 睡眠学(視床下部と睡眠)2009

    • Author(s)
      日本睡眠学会編
    • Publisher
      朝倉書店
    • Related Report
      2011 Final Research Report
  • [Book] 睡眠学(睡眠ニューロン活動の記録法)2009

    • Author(s)
      日本睡眠学会編
    • Publisher
      朝倉書店
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://kojingyoseki.adb.fukushima-u.ac.jp/top/details/196

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.sss.fukushima-u.ac.jp/welcome/download/17

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.sss.fukushima-u.ac.jp/welcome/professor_list

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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