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Chronic stress and depressive disorder : Research on preventive effect of odorant and its mechanism

Research Project

Project/Area Number 21590255
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionTottori University

Principal Investigator

WATANABE Tatsuo  鳥取大学, 医学部, 教授 (60182929)

Co-Investigator(Kenkyū-buntansha) KATO Shinsuke  鳥取大学, 医学部, 准教授 (60194817)
MICHIO Miyoshi  鳥取大学, 医学部, 助教 (20093627)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsストレス / うつ病 / 前頭前皮質 / 海馬 / 神経新生 / doublecortin / c-fos / Zif268 / 酪酸 / 緑の香り / 強制水泳試験 / 学習性無力試験 / immobility time / failure / ラット / 視床下部 / 下垂体 / 副腎
Research Abstract

We investigated whether inhalation of green odor(a mixture of equal amounts of trans-2-hexenal and cis-3-hexenal) cures and/or prevents the depressive disorders induced in rats. To this end, we used two behavioral models of depression, forced swim test and learned helplessness paradigms. The present results suggest that green odor has not only a therapeutic, but also a preventive effect on depressive-like states in rats.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (34 results)

All 2012 2011 2010 2009 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (16 results) Remarks (3 results)

  • [Journal Article] Effect of "rose essential oil" inhalation on stress-induced skin-barrier disruption in rats and humans2012

    • Author(s)
      Fukada, M., Kano, E., Miyoshi, M., Komaki, R. & Watanabe, T.
    • Journal Title

      Chemical Senses

      Volume: 37(4) Pages: 347-356

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of "rose essential oil" inhalation on stress-induced skin-barrier disruption in rats and humans2012

    • Author(s)
      Fukada M., et al
    • Journal Title

      Chemical Senses

      Volume: 37 Issue: 4 Pages: 347-356

    • DOI

      10.1093/chemse/bjr108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Green odor and depressive-like state in rats : Toward an evidence-based alternative medicine?2011

    • Author(s)
      Watanabe, T., Fujihara, M., Murakami, E., Miyoshi, M., Tanaka, Y., Koba, S. & Tachibana, H.
    • Journal Title

      Behavioural Brain Research

      Volume: 224(2) Pages: 290-296

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protective effects of ginger against aspirin-induced gastric ulcers in rats Yonago Acta medica2011

    • Author(s)
      Wang, Z., Hasegawa, J., Wang, X., Matsuda, A., Tokuda, T., Miura, N. & Watanabe, T.
    • Volume
      54
    • Pages
      11-19
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Green odor and depressive-like state in rats : Toward an evidence-based alternative medicine?2011

    • Author(s)
      Watanabe T., et al
    • Journal Title

      Behavioural Brain Research

      Volume: 224 Pages: 290-296

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic restraint stress in rats suppresses sweet and umami taste responses and lingual expression of T1R3 mRNA2010

    • Author(s)
      Okamoto, A., Miyoshi, M., Imoto, T., Ryoke, K., and Watanabe, T.
    • Journal Title

      Neuroscience Letters

      Volume: 486(3) Pages: 211-214

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] "Green odor" inhalation by stressed rat dams reduces behavioral and neuroendocrine signs of prenatal stress in the offspring2010

    • Author(s)
      Fujita, S., Ueki, S., Miyoshi, M., and Watanabe, T.
    • Journal Title

      Hormones and Behavior

      Volume: 58(2) Pages: 264-272

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of anterior hypothalamic natriuretic peptide in lipopolysaccharide-induced fever in rats2010

    • Author(s)
      Miyoshi, M. and Watanabe, T.
    • Journal Title

      European Journal of Applied Physiology

      Volume: 109(1) Pages: 49-57

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] "Green odor" inhalation by stressed rat dams reduces behavioral and neuroendocrine signs of prenatal stress in the offspring.2010

    • Author(s)
      Sayaka Fujita
    • Journal Title

      Hormones and Behavior

      Volume: 58(2) Pages: 264-272

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic restraint stress in rats suppresses sweet and umami taste responses and lingual expression of T1R3 mRNA.2010

    • Author(s)
      Atsuhiro Okamoto
    • Journal Title

      Neuroscience Letters

      Volume: 486(3) Pages: 211-214

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of anterior hypothalamic natriuretic peptide in lipopolysaccharide-induced fever in rats.2010

    • Author(s)
      Michio Miyoshi
    • Journal Title

      European Journal of Applied Physiology

      Volume: 109(1) Pages: 49-57

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] "Green odor" inhalation by rats down-regulates stress-induced increases in Fos expression in stress-related forebrain regions2009

    • Author(s)
      Ito, A., Miyoshi, M., Ueki, S., Fukada, M., Komaki, R. and Watanabe, T.
    • Journal Title

      Neuroscience Research

      Volume: 65(2) Pages: 166-174

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] "Green odor" inhalation by rats down-regulates stress-induced increases in Fos expression in stress-related forebrain regions.2009

    • Author(s)
      Ito, A.
    • Journal Title

      Neuroscience Research 65(2)

      Pages: 166-174

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of anterior hypothalamic natriuretic peptide in lipopolysaccharide-induced fever in rats.

    • Author(s)
      Miyoshi, M.
    • Journal Title

      European Journal of Applied Physiology (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] "Green odor" inhalation by stressed rat dams reduces behavioral and neuroendocrine signs of prenatal stress in the offspring.

    • Author(s)
      Fujita, S.
    • Journal Title

      Hormones and Behavior (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] うつ病に対する緑の香りの予防・治療効果について~ラットを用いた検討~2012

    • Author(s)
      渡邊達生
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] うつ病に対する緑の香りの予防・治療効果について~ラットを用いた検討~2012

    • Author(s)
      渡邉達生
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      リッチモンドホテル松本(松本市)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 緑の香りはラットのうつ病様状態を緩和する2011

    • Author(s)
      橘広人、渡邊達生
    • Organizer
      第50回日本生気象学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-11-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 緑の香りはラットのうつ病様状態を緩和する2011

    • Author(s)
      橘広人、渡漫達生
    • Organizer
      第50回日本生気象学会大会
    • Place of Presentation
      アパヴィラホテル<京都駅前>(京都市)
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] アンジオテンシンII由来高血圧ラットの活動筋反射は活性酸素によって増強される2011

    • Author(s)
      木場智史、渡辺亮介、狩野尚香、渡邊達生
    • Organizer
      第63回日本生理学会中国四国地方会
    • Place of Presentation
      広島
    • Year and Date
      2011-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] アンジオテンシンII由来高血圧ラットの活動筋反射は活性酸素によって増強される2011

    • Author(s)
      木場智史、渡辺亮介、狩野尚香、渡邉達生
    • Organizer
      第63回日本生理学会中国四国地方会
    • Place of Presentation
      ホテルセンチュリー21広島(広島市)
    • Year and Date
      2011-10-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 緑の香りのうつ病への効果2011

    • Author(s)
      橘広人
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      パシフィコ横浜会議センター(横浜市)(発表確定)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性ストレスの味覚に及ぼす効果2011

    • Author(s)
      岡本充浩
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      パシフィコ横浜 会議センター(横浜市)(発表確定)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 性周期は活動筋反射に影響する2010

    • Author(s)
      木場智史、吉永健嗣、藤田小矢香、渡邊達生
    • Organizer
      第62回日本生理学会中国四国地方会
    • Place of Presentation
      出雲
    • Year and Date
      2010-11-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 性周期は活動筋反射に影響する2010

    • Author(s)
      木場智史
    • Organizer
      第62回日本生理学会中国四国地方会
    • Place of Presentation
      島根大学医学部(出雲市)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発熱とアンジオテンシンII~炎症性サイトカイン産生促進作用について~2010

    • Author(s)
      渡邊達生
    • Organizer
      日本麻酔学会中国・四国支部第47回学術集会
    • Place of Presentation
      米子
    • Year and Date
      2010-09-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 発熱とアンジオテンシンII~炎症性サイトカイン産生促進作用について~2010

    • Author(s)
      渡邊達生
    • Organizer
      日本麻酔学会中国・四国支部第47回学術集会
    • Place of Presentation
      米子コンベンションセンター(米子市)(招待講演)
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 妊娠ラットの香料吸入で胎生期ストレスによる仔の内分泌・行動異常を抑制できるか?2010

    • Author(s)
      藤田小矢香、上木史織、三好美智夫、渡邊達生
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 妊娠ラットの香料吸入で胎生期ストレスによる仔の内分泌・行動異常を抑制できるか?2010

    • Author(s)
      藤田小矢香
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      いわて県民情報交流センター(盛岡市)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hypothalamic natriuretic peptide inhibits fever induced in rats by systemic administration of LPS2009

    • Author(s)
      Miyoshi, M., Watanabe, T.
    • Organizer
      The 3rd International Symposium on Physiology and Pharmacology of Temperature Regulation
    • Place of Presentation
      Matsue
    • Year and Date
      2009-07-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Hypothalamic natriuretic peptide inhibits fever induced in rats by systemic administration of LPS2009

    • Author(s)
      Miyoshi, M.
    • Organizer
      The 3rd International Symposium on Physiology and Pharmacology of Temperature Regulation
    • Place of Presentation
      島根県立産業交流会館
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.tottori-u.ac.jp/intgphys/6005.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.med.tottori-u.ac.jp/intgphys/6005.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.tottori-u.ac.jp/1/3/4/5/9.html

    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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