Identification of novel immune regulatory factors in the gut immune system and elucidation of molecular mechanisms for their function
| Project/Area Number |
21590260
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 栄養生理学 / 乳 / カゼイン / 腸管免疫 / 生理活性ペプチド / 遊走 / 細胞内カルシウム応答 / 牛乳 |
|---|
| Research Abstract |
We found that bovine milk casein and its digest with trypsin evoked intracellular calcium mobilization in the macrophage-like cell line through the Gi protein. A novel peptide sequence activating blood cells was identified fromαs1-casein. It was indicated that the unknown receptor coupled with Gi protein was involved in the intracellular calcium response to the peptide. Moreover, the peptide could activate the immune cells selectively.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Lovastatin alters TGF-β-induced epithelial-mesenchymal transition in porcine lens epithelial cells2012
Author(s)
Urakami, C., Kurosaka, D., Tamada, K., Kishimoto, S., Tezuka, Y. and Nishigori, H.
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Journal Title
Curr. Eye Res.
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Effect of vitamin C depletion on UVR-B induced cataract in SMP30/GNL knockout mice2012
Author(s)
Ishikawa, Y., Hashizume, K., Kishimoto, S. Tezuka, Y., Nishigori, H., Yamamoto, N., Kondo, Y., Maruyama, N., Ishigami, A. and Kurosaka, D.
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Journal Title
Exp. Eye Res.
Volume: Vol.94
Pages: 85-89
Related Report
Peer Reviewed
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[Journal Article] Double-Blind Study on Effects of Glucosyl Ceramide in Beet Extract on Skin Elasticity and Fibronectin Production in Human Dermal Fibroblasts2010
Author(s)
Hori, M., Kishimoto, S., Tezuka, Y. Nishigori, H., Nomoto, K., Hamada, U. and Yonei, Y.
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Journal Title
Anti-Aging Med.
Volume: Vol.7
Pages: 129-142
NAID
Related Report
Peer Reviewed
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[Journal Article] Effects of Betamethasone and Mifepristone(RU486) on Brain Acetylcholinesterase of Developing Chick Embryos2010
Author(s)
Yamate, S., Nishigori, H., Kishimoto, S., Tezuka, Y., Fukushima, A. and Nishigori, H.
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Journal Title
J. Obstet. Gynaecol. Res.
Volume: Vol.36
Pages: 11-18
Related Report
Peer Reviewed
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