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Suppressive role of histamine in inflammation-associated tumorigenesis

Research Project

Project/Area Number 21590268
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionYamaguchi University

Principal Investigator

KURAMASU Atsuo  山口大学, 大学院・医学系研究科, 准教授 (90302091)

Co-Investigator(Kenkyū-buntansha) SUKEGAWA Jun  東北大学, 大学院・医学系研究科, 准教授 (30187687)
YANAI Kazuhiko  東北大学, 大学院・医学系研究科, 教授 (50192787)
WATANABE Takehiko  東北大学, 大学院・医学系研究科, 名誉教授 (70028356)
SAKURAI Eiko  いわき明星大学, 薬学部, 教授 (90153949)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywordsヒスタミン / 炎症性発癌 / H2受容体 / シメチジン / 骨髄由来抑制細胞 / アゾキシメタン / デキストラン硫酸ナトリウム / ヒスチジン脱炭酸酵素 / 炎症 / 発癌 / ヒスタミン受容体拮抗薬
Research Abstract

Role of histamine in inflammation-associated tumorigenesis was investigated using mice deficient of endogenous histamine. In colitis-associated colon cancer model, mice lacking histamine had significantly larger tumors, suggesting that histamine has suppressive role in tumor growth. In spleen from histamine-deficient mice with colon tumor, myeloid-derived suppressor cells(MDSCs) were increased, showing a possible mechanism of MDSC-mediated suppression of anti-tumor immune response.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2011 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (3 results)

  • [Journal Article] The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H(3) receptor are involved in receptor-G-protein coupling2011

    • Author(s)
      Kuramasu A, Sukegawa J, Sato T, Sakurai E, Watanabe T, Yanagisawa T, Yanai K.
    • Journal Title

      Cell Signal

      Volume: Nov ; 23(11) Pages: 1843-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of hypothalamic subgroup histamine and orexin neurons on behavioral responses to sleep deprivation induced by the treadmill method in adolescent rats2010

    • Author(s)
      Xu A, Sakurai E, Kuramasu A, Zhang J, Li J, Okamura N, Zhang D, Yoshikawa T, Watanabe T, Yanai K.
    • Journal Title

      J Pharmacol Sci

      Volume: 114(4) Pages: 444-53

    • NAID

      10029891159

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of the histaminergic neurotransmission on methamphetamine-induced locomotor sensitization and reward : a study of receptors gene knockout mice2009

    • Author(s)
      Takino N, Sakurai E, Kuramasu A, Okamura N, Yanai K.
    • Journal Title

      Int Rev Neurobiol

      Volume: 85 Pages: 109-16

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple histamine receptor gene knockout mice and their phenotypes2009

    • Author(s)
      Sakurai E, Kuramasu A, Watanabe T, Yanai K.
    • Journal Title

      Inflamm Res

      Volume: 58 Pages: 41-2

    • Related Report
      2011 Final Research Report
  • [Presentation] ヒスタミンH4受容体を介するケモタキシスに図5.脾臓の骨髄由来抑制細胞数の比較おける低分子量Gタンパク質Racの関与2011

    • Author(s)
      倉増敦朗、若林深恵、乾誠、谷内一彦
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都国立京都国際会館
    • Year and Date
      2011-03-14
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒスタミンH3受容体のヘリックス8はGタンパク質との共役に重要である2009

    • Author(s)
      倉増敦朗、助川淳、櫻井映子、渡邉建彦、柳澤輝行、谷内一彦
    • Organizer
      第62回日本薬理学会西南部会
    • Place of Presentation
      愛媛リジェール松山
    • Year and Date
      2009-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒスタミンH4受容体を介するケモタキシスにおける低分子量Gタンパク質Racの関与2009

    • Author(s)
      倉増敦朗、若林深恵、谷内一彦
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      福岡KKRホテル博多
    • Year and Date
      2009-11-20
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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