Suppressive role of histamine in inflammation-associated tumorigenesis
| Project/Area Number |
21590268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KURAMASU Atsuo 山口大学, 大学院・医学系研究科, 准教授 (90302091)
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| Co-Investigator(Kenkyū-buntansha) |
SUKEGAWA Jun 東北大学, 大学院・医学系研究科, 准教授 (30187687)
YANAI Kazuhiko 東北大学, 大学院・医学系研究科, 教授 (50192787)
WATANABE Takehiko 東北大学, 大学院・医学系研究科, 名誉教授 (70028356)
SAKURAI Eiko いわき明星大学, 薬学部, 教授 (90153949)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | ヒスタミン / 炎症性発癌 / H2受容体 / シメチジン / 骨髄由来抑制細胞 / アゾキシメタン / デキストラン硫酸ナトリウム / ヒスチジン脱炭酸酵素 / 炎症 / 発癌 / ヒスタミン受容体拮抗薬 |
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| Research Abstract |
Role of histamine in inflammation-associated tumorigenesis was investigated using mice deficient of endogenous histamine. In colitis-associated colon cancer model, mice lacking histamine had significantly larger tumors, suggesting that histamine has suppressive role in tumor growth. In spleen from histamine-deficient mice with colon tumor, myeloid-derived suppressor cells(MDSCs) were increased, showing a possible mechanism of MDSC-mediated suppression of anti-tumor immune response.
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Report
(4 results)
Research Products
(7 results)
