| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
In brain microglia, alpha 7 nicotinic receptor activation induced calcium release from intracellular calcium stores through tyrosine-kinase-dependent metabotropic pathways. This calcium response was enhanced under acidic condition or oxidative stress and thereby suppressed lipopolysaccharide(LPS)-induced production of inflammatory cytokines. LPS stimulation also promotes long survival and protective function such as phagocytosis in microglia. Since alpha 7 nicotinic receptors play a role in facilitating protective function in microglia, this receptor subtype may be a potential target for brain inflammatory diseases.
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