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Involvement of a non-neuronal cardiac cholinergic system in energy metabolism and pathophysiological situations

Research Project

Project/Area Number 21590283
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionKochi University

Principal Investigator

KAKINUMA Yoshihiko  高知大学, 教育研究部・医療学系, 准教授 (40233944)

Co-Investigator(Renkei-kenkyūsha) SATO Takayuki  高知大学, 教育研究部・医療学系, 教授 (90205930)
ARIKAWA Mikihiko  高知大学, 教育研究部・医療学系, 助教 (20432817)
NOGUCHI Tatsuya  高知大学, 教育研究部・医療学系, 助教 (50566495)
ZHENG Can  高知大学, 教育研究部・医療学系, 助教 (50443495)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords心血管 / 血液 / アセチルコリン / 心臓 / エネルギー代謝 / 酸素消費量 / ミトコンドリア / 心筋細胞
Research Abstract

We have so far reported novel effects of parasympathetic nerve system-derived ACh in the cardiovascular system. Recently it has been reported that a cholinergic system is composed of a classical parasympathetic nerve system and a non-neuronal cholinergic system. The classical parasympathetic nerve system plays a role in inhibiting a function of sympathetic nerve system, i. e., decreasing of heart rate and cardiac contraction. In contrast, the non-neuronal cholinergic system means that ACh is synthesized by a cell at its local site, and a non-neuronal cardiac cholinergic system is that one cardiomyocytes synthesizes ACh independently from the classical parasympathetic nerve system. Novel functions of ACh other than modulating sympathetic nerve, which we have identified, includes anti-arrhythmogenic effects, anti-apoptotic effects, hypoxia tolerance effects and angiogenesis accelerating effects. It is expected that those effects are also regulated by the non-neuronal cardiac cholinergic system. In the current study, we have revealed that this system plays a role in negatively regulating cellular energy metabolism, preventing cells from overshooting oxygen consumption leading to cell protection, and that this system is upregulated by pharmacological intervention and some manipulation other than drugs. Taken together, these results raise a possibility that this system can be a therapeutic target and a tool to profoundly understand a pathophysiology of cardiovascular diseases.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (63 results)

All 2012 2011 2010 2009

All Journal Article (20 results) (of which Peer Reviewed: 18 results) Presentation (43 results)

  • [Journal Article] Systemic inflammation impairs cardiac glucose uptake2012

    • Author(s)
      Kakinuma Y, Okada S, Nogami M, Sano S, Kumon Y.
    • Journal Title

      Int J Cardiol

      Volume: 154 Pages: 203-204

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced manner reinforcing resistance to endothelium-targeted glomerulonephropathy2011

    • Author(s)
      Morita T, Kakinuma Y, Kurabayashi A, Fujieda M, Sato T, Shuin T, Furihata M, Wakiguchi H
    • Journal Title

      Nephrol Dial Transpl

      Volume: 26 Pages: 4023-4031

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Donepezil, Anti-Alzheimer' s Disease Drug, Prevents Cardiac Rupture during Acute Phase of Myocardial Infarction in Mice2011

    • Author(s)
      Arikawa M, Kakinuma Y, Handa T, Yamasaki F, Sato T
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] アセチルコリンのpleiotropic actionから心筋内アセチルコリン産生系まで2011

    • Author(s)
      柿沼由彦
    • Journal Title

      自律神経

      Volume: 48 Pages: 173-175

    • NAID

      10029549389

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Donepezil, anti-Alzheimer's disease drug, prevents cardiac rupture during acute phase of myocardial infarction in mice2011

    • Author(s)
      Arikawa M, Kakinuma Y, et al
    • Journal Title

      PLoS One

      Volume: 6 Issue: 7 Pages: e20629-e20629

    • DOI

      10.1371/journal.pone.0020629

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced manner reinforcing resistance to endothelium-targeted glomerulonephropathy2011

    • Author(s)
      Morita T, Kakinuma Y, et al
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26 Issue: 12 Pages: 4023-4031

    • DOI

      10.1093/ndt/gfr176

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of TNF receptors by vagal nerve stimulation protects heart against acute ischemic injury2010

    • Author(s)
      Katare RG, Ando M, Kakinuma Y, Arikawa M, Yamasaki F, Sato T
    • Journal Title

      J Mol Cell Cardiol

      Volume: 49 Pages: 234-244

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Engineered heart tissue : a novel tool to study the ischemic changes of the heart in vitro2010

    • Author(s)
      Katare RG, Ando M, Kakinuma Y, Sato T
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Donepezil, an acetylcholinesterase inhibitor against Alzheimer' s dementia, promotes angiogenesis in an ischemic hindlimb model2010

    • Author(s)
      Kakinuma Y, Furihata M, Akiyama T, Arikawa M, Handa T, Katare RG, Sato T
    • Journal Title

      J Mol Cell Cardiol

      Volume: 48 Pages: 680-693

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model.2010

    • Author(s)
      Kakinuma Y, Furihata M, et al.
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 48 Pages: 680-693

    • NAID

      120002069739

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of TNF receptors by vagal nerve stimulation protects heart against acute ischemic injury.2010

    • Author(s)
      Katare RG, Ando M, Kakinuma Y, et al.
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 49 Pages: 234-244

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model2010

    • Author(s)
      Kakinuma Y
    • Journal Title

      J Molecular and Cellular Cardiology 48

      Pages: 680-693

    • NAID

      120002069739

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Engineered heart tissue : a novel tool to study the ischemic changes of the heart in vitro2010

    • Author(s)
      Katare RG
    • Journal Title

      PLoS One 17

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium2009

    • Author(s)
      Kakinuma Y, Akiyama T, Sato T
    • Journal Title

      FEBS J

      Volume: 276 Pages: 5111-5125

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-Alzheimer' s drug, donepezil, markedly improves long-term survival after chronic heart failure in mice2009

    • Author(s)
      Handa T, Katare RG, Kakinuma Y, Arikawa M, Ando M, Sasaguri S, Yamasaki F, Sato T
    • Journal Title

      J Card Fail

      Volume: 15 Pages: 805-811

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/ VEGF/ PI3K signaling pathway2009

    • Author(s)
      Katare GR, Kakinuma Y, Arikawa M, Yamasaki F, Sato T
    • Journal Title

      J Mol Cell Cardiol

      Volume: 46 Pages: 405-412

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect2009

    • Author(s)
      Katare GR, Ando M, Kakinuma Y, Arikawa M, Handa T, Yamasaki F, Sato T
    • Journal Title

      J Thorac Cardiovasc Surgery

      Volume: 137 Pages: 223-231

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Donepezilを使用した容量負荷心不全マウスにおける心機能改善効果2009

    • Author(s)
      半田武巳、Katare GR、柿沼由彦、有川幹彦、安藤元規、山崎文靖、佐藤隆幸、篠栗志朗
    • Journal Title

      生存率改善効果の検討心臓

      Volume: 41 Pages: 115-123

    • Related Report
      2011 Final Research Report
  • [Journal Article] Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium2009

    • Author(s)
      Kakinuma Y
    • Journal Title

      FEBS J 276

      Pages: 5111-5125

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-Alzheimer's Drug, Donepezil, Markedly Improves Long-Term Survival After Chronic Heart Failure in Mice2009

    • Author(s)
      Handa T
    • Journal Title

      J Cardiac Failure 15

      Pages: 805-811

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Donepezil prevents cardiac rupture during acute phase of myocardial infarction in mice2012

    • Author(s)
      Arikawa M, KakinumaY, Noguchi T, Sato T
    • Organizer
      第89回日本生理学会大会長野県松本市文化会館
    • Place of Presentation
      長野
    • Year and Date
      2012-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Donepezil prevents cardiac rupture during acute phase of myocardial infarction in mice2012

    • Author(s)
      Arikawa M, Kakinuma Y, Noguchi T, Sato T
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館(長野県)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] A non-neuronal cardiac cholinergic system(nNCCS) in cardiomyocytes plays a role in suppressing overshooting energy metabolism2012

    • Author(s)
      Kakinuma Y, Akiyama T, Sato T
    • Organizer
      第89回日本生理学会大会長野県松本市文化会館
    • Place of Presentation
      長野
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] A non-neuronal cardiac cholinergic System(nNCCS) in cardiomyocytes plays a role in suppressing overshooting energy metabolism2012

    • Author(s)
      Kakinuma Y, Akiyama T, Sato T
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館(長野県)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Donepezil, an Acetylcholinesterase Inhibitor, Prevents Cardiac Rupture during Acute Phase of Myocardial Infarction in Mice2012

    • Author(s)
      Arikawa M, Kakinuma Y, Noguchi T, Yamasaki F, Satoh T
    • Organizer
      第76回日本循環器学会学術総会
    • Place of Presentation
      福岡国際会議場福岡
    • Year and Date
      2012-03-17
    • Related Report
      2011 Final Research Report
  • [Presentation] トピックス2非薬物的自律神経介入治療の最前線Cholinoceptive Cholinergic Properties of Cardiomyocytes : Amplification Mechanism for Vagal Efferent Effects2012

    • Author(s)
      柿沼由彦
    • Organizer
      第76回日本循環器学会学術総会
    • Place of Presentation
      福岡国際会議場福岡
    • Year and Date
      2012-03-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 非薬物的自律神経介入治療の最前線Cholinoceptive Cholinergic Properties of Cardiomyocytes : Amplification Mechanism for Vagal Efferent Effects2012

    • Author(s)
      柿沼由彦
    • Organizer
      第76回日本循環器学会学術総会
    • Place of Presentation
      福岡国際会議場(福岡県)(招待講演)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Donepezil, an Acetylcholinesterase Inhibitor, Prevents Cardiac Rupture during Acute Phase of Myocardial Infarction in Mice2012

    • Author(s)
      Arikawa M, Kakinuma Y, et al
    • Organizer
      第76回日本循環器学会学術総会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] ドネペジルはマウス心筋梗塞モデルにおいて、マクロファージMMP-9産生を抑制し急性期心破裂の危険率を低減する2011

    • Author(s)
      有川幹彦,柿沼由彦,野口達哉,佐藤隆幸
    • Organizer
      第63回日本生理学会中国四国地方会
    • Place of Presentation
      広島大学
    • Year and Date
      2011-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] ドネペジルは、マウス心筋梗塞モデルにおいて、マクロファージMMP-9産生を抑制し急性期心破裂の危険率を低減する2011

    • Author(s)
      有川幹彦, 柿沼由彦, 野口達哉, 佐藤隆幸
    • Organizer
      第63回日本生理学会中国四国地方会
    • Place of Presentation
      広島大学(広島県)
    • Year and Date
      2011-10-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心筋細胞内アセチルコリン産生系の生物学的意義2011

    • Author(s)
      柿沼由彦,秋山剛,有川幹彦,岡崎佳代,佐藤隆幸
    • Organizer
      第63回日本生理学会中国四国地方会
    • Place of Presentation
      広島大学
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 心筋細胞内アセチルコリン産生系の生物学的意義2011

    • Author(s)
      柿沼由彦, 秋山剛, 有川幹彦, 岡崎佳代, 佐藤隆幸
    • Organizer
      第63回日本生理学会中国四国地方会
    • Place of Presentation
      広島大学(広島県)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Acetylcholinesterase Inhibitor Donepezil in Treatment of Myocardial Ischemia and Heart Failure2011

    • Author(s)
      Arikawa M, Kakinuma Y, Noguchi T, Sato T
    • Organizer
      ISAN/ AAS2011(Satellite Meeting) Rio de janeiro
    • Place of Presentation
      Brasil
    • Year and Date
      2011-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Acetylcholinesterase Inhibitor Donepezil in Treatment of Myocardial Ischemia and Heart Failure2011

    • Author(s)
      Arikawa M, Kakinuma Y, Noguchi T, Sato T
    • Organizer
      ISAN/AAS2011 (Satellite Meeting)
    • Place of Presentation
      Rio de janeiro, Brasil
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Beneficial Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Heart Failure2011

    • Author(s)
      Kubo T, Kitaoka H, Kakinuma Y, Sato T, Doi Y
    • Organizer
      第75回日本循環器学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-08-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] ドネペジルは、マウス心筋梗塞モデルにおいて、マクロファージMMP-9の産生を抑制することにより急性期心破裂の危険率を低減する2011

    • Author(s)
      有川幹彦、柿沼由彦、野口達哉、佐藤隆幸
    • Organizer
      第12回Neurocardiology Workshop東京ステーションコンファレンス
    • Place of Presentation
      東京都
    • Year and Date
      2011-07-30
    • Related Report
      2011 Final Research Report
  • [Presentation] ドネペジルは、マウス心筋梗塞モデルにおいて、マクロファージMMP-9の産生を抑制することにより急性期心破裂の危険率を低減する2011

    • Author(s)
      有川幹彦, 柿沼由彦, 他
    • Organizer
      第12回Neurocardiology Workshop
    • Place of Presentation
      東京ステーションコンファレンス(東京都)
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular mechanisms of muscular abnormality in transgenic mice overexpressing NF90, a dsRNA binding protein2011

    • Author(s)
      Sakamoto S, Higuchi T, Kakinuma Y, et al
    • Organizer
      16th Annual Meeting of the RNA Society
    • Place of Presentation
      京都国際会議場(京都府)
    • Year and Date
      2011-06-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced fashion to reinforce resistance to endothelium-targeted glomerulonephropathy2011

    • Author(s)
      Morita T, Kakinuma Y, et al
    • Organizer
      11th Asian Congress of Pediatric Nephrology 2011
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Molecular mechanisms of muscular abnormality in transgenic mice overexpressing NF90, a dsRNA binding protein2011

    • Author(s)
      Sakamoto S, Higuchi T, Kakinuma Y, Kai S, Todaka H, Yagyu K, Obata E, Morisawa K, Fukushima A, Tsuda M, Taniguchi T
    • Organizer
      16^<th> Annual Meeting of the RNA Society
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced fashion to reinforce resistance to endothelium-targeted glomerulonephropathy2011

    • Author(s)
      Morita T, Kakinuma Y, Kurabayashi A, Fujieda M, Sato T, Shuin T, Furihata M, Wakiguchi H
    • Organizer
      11^<th> Asian Congress of Pediatric Nephrology 2011
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Beneficial Effects of Donepezil, an Acetylcholinesterase Inhibitor, on Heart Failure2011

    • Author(s)
      Kubo T, Kitaoka H, Kakinuma Y, Satoh T, Doi Y
    • Organizer
      第75回日本循環器学会学術総会
    • Place of Presentation
      パシフィコ横浜神奈川
    • Related Report
      2011 Final Research Report
  • [Presentation] Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced fashion to reinforce resistance to endothelium-targeted glomerulonephropathy2011

    • Author(s)
      Morita T, Kakinuma Y, Kurabayashi A, Fujieda M, Sato T, Shuin T, Furihata M, Wakiguchi H
    • Organizer
      第46回日本小児腎臓病学会学術集会
    • Place of Presentation
      福岡国際会議場福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] アセチルコリンのpleiotrophic actionから心筋内アセチルコリン産生系まで2010

    • Author(s)
      柿沼由彦
    • Organizer
      第63回日本自律神経学会総会
    • Place of Presentation
      ワークピア横浜(神奈川)
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Donepezil, an acetylcholinesterase inhibitor, reduces the risk of left ventricular free wall rapture during an acute phase of myocardial infarction by attenuating macrophage matrix metalloproteinase-9.2010

    • Author(s)
      Arikawa M
    • Organizer
      19th International Conference of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Kyushu University (Fukuoka)
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] The new era of therapeutic modalities against heart failure, focusing on pharmacological intervention of the cardiovascular cholinergic system.2010

    • Author(s)
      Kakinuma Y
    • Organizer
      19th International Conference of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Kyushu University (Fukuoka)
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of a non-neuronal cholinergic system equipped for cardiomyocytes, as a molecular brake, on overshooting cardiac energymetabolism.2010

    • Author(s)
      Kakinuma Y
    • Organizer
      19th International Conference of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Kyushu University (Fukuoka)
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 心筋細胞内アセチルコリン産生系の生物学的意義2010

    • Author(s)
      柿沼由彦
    • Organizer
      第11回Neurocardiology Workshop
    • Place of Presentation
      東京ステーションコンファレンス
    • Year and Date
      2010-07-31
    • Related Report
      2011 Final Research Report
  • [Presentation] 塩酸ドネペジル内服による心血管系への影響に関する前向き登録調査研究2010

    • Author(s)
      久保亨、西永正典、柿沼由彦、佐藤隆幸、土居義典
    • Organizer
      第11回Neurocardiology Workshop
    • Place of Presentation
      東京ステーションコンファレンス
    • Year and Date
      2010-07-31
    • Related Report
      2011 Final Research Report
  • [Presentation] 心筋細胞内アセチルコリン産生系の生物学的意義2010

    • Author(s)
      柿沼由彦
    • Organizer
      第11回 Neurocardiology Workshop
    • Place of Presentation
      東京ステーションコンファレンス(東京)
    • Year and Date
      2010-07-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 塩酸ドネペジル内服による心血管系への影響に関する前向き登録調査研究2010

    • Author(s)
      久保亨
    • Organizer
      第11回 Neurocardiology Workshop
    • Place of Presentation
      東京ステーションコンファレンス(東京)
    • Year and Date
      2010-07-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 非中枢性細胞内アセチルコリン産生系がもつ多様な生物学的意義について2010

    • Author(s)
      柿沼由彦
    • Organizer
      第5回旭川医科大学脈管クラスター研究会
    • Place of Presentation
      旭川医科大学
    • Year and Date
      2010-06-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 非中枢性細胞内アセチルコリン産生系がもつ多様な生物学的意義について2010

    • Author(s)
      柿沼由彦
    • Organizer
      第5回 旭川医科大学脈管クラスター研究会
    • Place of Presentation
      旭川医科大学(北海道)
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of a non-central and non-neuronal acetylcholine synthesis system equipped for cardiomyocytes, as a molecular brake, on overshooting cardiac energy metabolism.2010

    • Author(s)
      Kakinuma Y
    • Organizer
      第31回日本循環制御医学会総会
    • Place of Presentation
      千里ライフセンター(大阪)
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of a non-central and non-neuronal acetylcholine synthesis system equipped for cardiomyocytes, as a molecular brake, on overshooting cardiac energy metabolism2010

    • Author(s)
      Kakinuma Y
    • Organizer
      第74回日本循環器学会学術総会
    • Place of Presentation
      京都国際会館(京都)
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Donepezil, an acetylcholinesterase inhibitor, reduces the risk of left ventricular free wall rapture during an acute phase of myocardial infarction by attenuating macrophage matrix metalloproteinase-92010

    • Author(s)
      Arikawa M, Kakinuma Y, Yamasaki F, Sato T
    • Organizer
      19^<th> International Conference of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] The new era of therapeutic modalities against heart failure, focusing on pharmacological intervention of the cardiovascular cholinergic system2010

    • Author(s)
      Kakinuma Y, Sato T
    • Organizer
      19^<th> International Conference of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of a non-neuronal cholinergic system equipped for cardiomyocytes, as a molecular brake, on overshooting cardiac energy metabolism2010

    • Author(s)
      Kakinuma Y, Akiyama T, Arikawa M, Sato T
    • Organizer
      19^<th> International Conference of the Cardiovascular System Dynamics Society
    • Place of Presentation
      Fukuoka, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] アセチルコリンのpleiotrophic actionから心筋内アセチルコリン産生系まで2010

    • Author(s)
      柿沼由彦
    • Organizer
      第63回日本自律神経学会総会
    • Place of Presentation
      ワークピア横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of a non-central and non-neuronal acetylcholine synthesis system equipped for cardiomyocytes, as a molecular brake, on overshooting cardiac energy metabolism2010

    • Author(s)
      Kakinuma Y, Akiyama T, Arikawa M, Handa T, Sato T
    • Organizer
      第31回日本循環制御医学会総会
    • Place of Presentation
      千里ライフセンター大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of a non-neuronal acetylcholine synthesis system equipped for cardiomyocytes, as a molecular brake, on overshooting cardiac energy metabolism2010

    • Author(s)
      Kakinuma Y, Akiyama T, Arikawa M, Handa T, Sato T
    • Organizer
      第74回日本循環器学会学術総会
    • Place of Presentation
      京都国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] VHL遺伝子不活性化によるマウス虚血再潅流障害の抑制2009

    • Author(s)
      森田拓、井口みつこ、柿沼由彦、倉林睦、藤枝幹也、脇口宏、執印太郎、佐藤隆幸、降幡睦夫
    • Organizer
      第52回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Donepezil, an Acetylcholinesterase Inhibitor Against Alzheimers Dementia, Prevents Remodeling in Volume-Overload Heart Failure Mice : Local and Central effect of Donepezil2009

    • Author(s)
      Handa T, Sato T, Kakinuma Y, Arikawa M, Sasaguri S
    • Organizer
      第73回日本循環器学会学術総会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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