The elucidation of the mechanisms underlying anticancer drug-induced peripheral neuropathy and its prophylaxis.
| Project/Area Number |
21590285
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
OISHI Ryozo 九州大学, 大学病院, 教授 (90112325)
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| Co-Investigator(Renkei-kenkyūsha) |
EGASHIRA Nobuaki 九州大学, 大学病院, 准教授 (80352269)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | オキサリプラチン / パクリタキセル / 末梢神経障害 / 機械的アロディニア / 低温 / 低温知覚異常 / カルシウム拮抗薬 / 牛車腎気丸 / NMDA受容体 / NR2Bサブユニット / イフェンプロジル / ノイロトロピン / メキシレチン |
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| Research Abstract |
The present study elucidated that the L type Ca2+ channels/NFAT/TRPM8 pathway plays a key role on oxaliplatin-induced cold hyperalgesia in rats, and Ca2+ channel blockers have prophylactic potential against that acute neuropathy caused by oxaliplatin. It was also found that the up-regulation of spinal NMDA receptor NR2B subunit involves in oxaliplatin-induced mechanical allodynia. Moreover, ifenfrodil and neurotropin could suppress the mechanical allodynia induced by oxaliplatin in rats.
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Report
(4 results)
Research Products
(52 results)
