| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
The present study elucidated that the L type Ca2+ channels/NFAT/TRPM8 pathway plays a key role on oxaliplatin-induced cold hyperalgesia in rats, and Ca2+ channel blockers have prophylactic potential against that acute neuropathy caused by oxaliplatin. It was also found that the up-regulation of spinal NMDA receptor NR2B subunit involves in oxaliplatin-induced mechanical allodynia. Moreover, ifenfrodil and neurotropin could suppress the mechanical allodynia induced by oxaliplatin in rats.
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