| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We established a method for quantification of intracellular 8-nitro-cGMP, a second messenger in antioxidant adaptive response, and revealed the involvement of mitochondria and NADPH oxidase in 8-nitro-cGMP formation in cells. We also found that S-guanylation of Keap1 by 8-nitro-cGMP, and subsequent Nrf2 activation and induction of antioxidant proteins expression, are important mechanisms in adaptive response against oxidative stress.
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