| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Diabetic complications are correlated with dysfunction of small arteries. The objective of this study was to identify alterations of endothelial cell-denuded micro-vascular including mesenteric artery second branch (MA2) and interlobar artery (ILA) contractions as typical small arteries. Both MA2 and ILA tissues were isolated from male type 2 diabetic ob/ob mice aged 16–22 weeks and age-matched control (Lean) mice. Phenylephrine (PE)-induced contractions were assessed under normal and high-glucose (HG; twice normal glucose concentration) conditions using our originally established measurement system. In MA2, PE-induced contractile responses were reduced in ob/ob mouse and HG-dependent enhancement of the contraction also suppressed compared to the Lean mouse. Oppositely, contraction in ob/ob mouse ILA was increased and HG-dependent enhancement was also detected. These findings indicated that the diabetic micro-vascular functions were individually altered in each tissue.
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