Studies of micro-vascular dysfunctions in diabetic complications.
| Project/Area Number |
21590290
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Josai University (2012-2013)
Showa University (2009-2011) |
|---|
Principal Investigator |
NOBE KOJI 城西大学, 薬学部, 准教授 (30276612)
|
|---|
| Project Period (FY) |
2009-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 糖尿病 / 合併症 / 血管平滑筋 / 糖尿病性腎症 / 微小血管障害 / 腎血管障害 / 高血糖 / 腎症 / 血管 / 腎動脈 / 収縮 / インスリン / 末梢抵抗血管 / 微小血管 / 収縮反応 |
|---|
| Research Abstract |
Diabetic complications are correlated with dysfunction of small arteries. The objective of this study was to identify alterations of endothelial cell-denuded micro-vascular including mesenteric artery second branch (MA2) and interlobar artery (ILA) contractions as typical small arteries. Both MA2 and ILA tissues were isolated from male type 2 diabetic ob/ob mice aged 16–22 weeks and age-matched control (Lean) mice. Phenylephrine (PE)-induced contractions were assessed under normal and high-glucose (HG; twice normal glucose concentration) conditions using our originally established measurement system. In MA2, PE-induced contractile responses were reduced in ob/ob mouse and HG-dependent enhancement of the contraction also suppressed compared to the Lean mouse. Oppositely, contraction in ob/ob mouse ILA was increased and HG-dependent enhancement was also detected. These findings indicated that the diabetic micro-vascular functions were individually altered in each tissue.
|
Report
(6 results)
Research Products
(6 results)
