Identification of D-serine-related gene and elucidation of etiology of schizophrenia using genetically modified animals

• Project/Area Number: 21590292
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Tokai University
• Principal Investigator: HASHIMOTO Atsushi 東海大学, 医学部, 准教授 (80271592)
• Co-Investigator(Kenkyū-buntansha): 吉川 正信 東海大学, 医学部, 講師 (90276791)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 中枢 / 末梢神経 / セリンラセマーゼ / D-セリン / ノックアウトマウス / 統合失調症

Research Abstract

We have investigated the identification of schizophrenia-related genes and the elucidation of genetically modified animals as schizophrenia-model animals using genetically modified animals. Using DNA microarrays, a variety of genes was increased and decreased. A stimulant exposure resulted in the increase of abnormal behaviors in the genetically modified animals compared to the wild mice. These data indicated that the genetically modified animals could be the model animals of schizophrenia.

Research Products

• [Journal Article] Subchronic administration of Ketamine decreases the mRNA exppresion of serine racemase in rat brain (2010)
  • Author(s): Watamabe M., Yoshikawa M., Takeyama K., Hashimoto A., Kobayashi H. and Suzuki T.
  • Journal Title: Tokai J. Exp. Clin. Med Volume: 35 Pages: 137-143
  • Peer Reviewed
• [Journal Article] Subchronic Administration of Ketamine Decreases the mRNA Expression of Serine Racemase in Rat Brain (2010)
  • Author(s): Mariko Watanabe, et al.
  • Journal Title: Tokai J Exp.Clin.Med. Volume: 35 Pages: 137-143
  • Peer Reviewed
• [Journal Article] The antinociceptive effects of midazolam on three different types of nociception in mice (2009)
  • Author(s): Masanobu Yoshikawa, et.al.
  • Journal Title: Journal of Pharmacological Sciences 109 Pages: 71-77
  • NAID: 10025733715
  • Peer Reviewed
• [Journal Article] Inhibitory effect of low-dose pentazocine on the development of antinociceptive tolerance to morphine (2009)
  • Author(s): Shunsuke Chiba, et.al.
  • Journal Title: Journal of Anesthesia 23 Pages: 99-107
  • Peer Reviewed
• [Presentation] セリンラセマーゼノックアウトマウスでは覚醒剤により誘発された常同行動は増加する (2010)
  • Author(s): 齋藤啓一郎、井上蘭、森寿、小林広幸、鈴木利保、橋本篤司
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-03-18
• [Presentation] セリンラセマーゼノックアウトマウスでは、覚醒剤により誘発された常同行動は増加する (2010)
  • Author(s): 齋藤啓一郎
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-03-18
• [Presentation] ケタミン長期投与によるD-セリン代謝関連酵素遺伝子発現の変化 (2009)
  • Author(s): 渡邊真理子、吉川正信、竹山和秀、村田智彦、金幸禄、小林智美、橋本篤司、小林広幸、鈴木利保
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2009-03-16