Identification of D-serine-related gene and elucidation of etiology of schizophrenia using genetically modified animals
| Project/Area Number |
21590292
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉川 正信 東海大学, 医学部, 講師 (90276791)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 中枢 / 末梢神経 / セリンラセマーゼ / D-セリン / ノックアウトマウス / 統合失調症 |
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| Research Abstract |
We have investigated the identification of schizophrenia-related genes and the elucidation of genetically modified animals as schizophrenia-model animals using genetically modified animals. Using DNA microarrays, a variety of genes was increased and decreased. A stimulant exposure resulted in the increase of abnormal behaviors in the genetically modified animals compared to the wild mice. These data indicated that the genetically modified animals could be the model animals of schizophrenia.
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Report
(4 results)
Research Products
(7 results)
