Involvement of Cdk5 signaling in cough hypersensitivity during chronic cough

• Project/Area Number: 21590294
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Hoshi University
• Principal Investigator: KAMEI Junzo 星薬科大学, 薬学部, 教授 (40161236)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 中枢・末梢神経 / 慢性咳嗽 / テトロドトキシン(TTX) / TTX抵抗性Na^+チャネル / TTX感受性Na^+チャネル / C線維 / Cdk5 / 慢性咳漱 / テトロドトキシン / TTX抵抗性ナトリムチャネル / アレルギー性気道炎症 / 一酸化窒素 / タキキニン / システニル-ロイコトリエン / カプサイシン

Research Abstract

The C-fiber sensitizing mechanisms have an important role in the enhancement of cough receptor sensitivity in chronic coughs. Cdk5-dependent factors are involved in these C-fiber-mediated cough sensitization.

Research Products

• [Journal Article] Possible involvement of tetrodotoxin-resistant sodium channels in cough (2011)
  • Author(s): Kamei J, Nakanishi Y, Ishikawa Y, Hayashi SS, Asato M and Ohsawa M
  • Journal Title: European Journal of Pharmacology Volume: 652 Pages: 117-120
• [Journal Article] Possible involvement of tetrodotoxin-resistant sodium channels in cough reflex (2011)
  • Author(s): J.Kamei, et al
  • Journal Title: Eur.J.Pharmacol. Volume: 652 Issue: 1-3 Pages: 117
  • DOI: 10.1016/j.ejphar.2010.11.019
  • Peer Reviewed
• [Journal Article] Possible involvement of tetrodotoxin-resistant sodium channels in cough reflex (2011)
  • Author(s): J.Kamei, et al.
  • Journal Title: Eur.J.Pharmacol. Volume: 652 Pages: 117-120
  • Peer Reviewed
• [Journal Article] Bronchoconstriction-triggered cough in conscious guinea pigs (2009)
  • Author(s): Ohkura N, Fujimura M, Hara J, Ohsawa M, Kamei J. and Nakao S
  • Journal Title: Experimental Lung Research Volume: 35 Pages: 296-306
• [Journal Article] Bronchoconstriction-triggered cough in conscious guinea pigs. (2009)
  • Author(s): Ohkura N, Fujimura M, Hara J, Ohsawa M, Kamei J, Nakao S.
  • Journal Title: Experimental Iung research 35 Pages: 296-306
  • Peer Reviewed
• [Presentation] Role of nitric oxide in the enhancement of C-fiber-mediated cough sensitivity. In cases of allergic airway inflammation and gastroesophageal reflux disease(GERD)- (2012)
  • Author(s): Kamei J
  • Organizer: China-Japan-UK Joint Summit on Cough
  • Place of Presentation: 上海中華人民共和国
  • Year and Date: 2012-04-20
• [Presentation] Role of nitric oxide in the enhancement of C-fiber-mediated cough sensitivity-In cases of allergic airway inflammation and gastroesophageal reflux disease (GERD)- (2012)
  • Author(s): Kamei, J
  • Organizer: China-Japan-UK Joint Summit on Cough
  • Place of Presentation: 中国、上海、上海国際会議場
  • Year and Date: 2012-04-20
• [Presentation] 咳嗽反射におけるナトリウムチャネルNav1.7αサブユニットの関与 (2012)
  • Author(s): 中西友樹、藤平智子、朝戸めぐみ、池田弘子、亀井淳三
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-16
• [Presentation] Possible involvement of Nav1.7 sodium channels in cough reflex (2012)
  • Author(s): Nakanishi, Y., Fujihira, T., Asato, M., Ikeda, H., Kamei, J.
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都市、京都国際会館
  • Year and Date: 2012-03-16
• [Presentation] 咳嗽反射におけるテトロドトキシン抵抗性ナトリウムチャネルの関与 (2011)
  • Author(s): 中西友樹、石川蓉子、林隼輔、藤平智子、朝戸めぐみ、池田弘子、亀井淳三
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-22
• [Presentation] 咳嗽反射誘発におけるテトロドトキシン抵抗性ナトリウムチャネルの関与 (2011)
  • Author(s): Y.Nakanishi, Y.Ishikawa, S.Hayashi, T, Fujihira, M.Asato, H.Ikeda, J.Kamei
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-22
• [Presentation] GERD様モデルマウスにおけるC線維を介した咳嗽亢進 (2010)
  • Author(s): 中西友樹、朝戸めぐみ、亀井淳三
  • Organizer: 第12回日本咳嗽研究会
  • Place of Presentation: 福岡
  • Year and Date: 2010-11-13
• [Presentation] GERD様モデルマウスにおけるC線維を介した咳漱亢進 (2010)
  • Author(s): 中西友樹、朝戸めぐみ、亀井淳三
  • Organizer: 第12回日本咳漱研究会
  • Place of Presentation: 福岡
  • Year and Date: 2010-11-13
• [Presentation] 慢性咳嗽の病態は基礎的にどこまで解明されるか (2009)
  • Author(s): 亀井淳三
  • Organizer: 第11回日本咳嗽研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-14
• [Remarks]
  • URL: http://polaris.hoshi.ac.jp/kyoshitsu/chiryou/index.html
• [Remarks]
  • URL: http://polaris.hoshi.ac.jp/kyoshitsu/chiryou/index.html