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Investigation of the mechanisms involving PTFE graft occlusion and searching its pharmacotherapeutics with chymase inhibitor

Research Project

Project/Area Number 21590295
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionOsaka Medical College

Principal Investigator

JIN Denan  大阪医科大学, 医学部, 講師 (90319533)

Co-Investigator(Renkei-kenkyūsha) TAKAI Shinji  大阪医科大学, 医学部, 准教授 (80288703)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords人工血管 / PTFE / グラシル / 狭窄 / アンジオテンシンII / キマーゼ / PTEE / 血管内膜肥厚 / アンジオテンシン変換酵素(ACE) / グラフト
Research Abstract

The inside neointima formation of polytetrafluoroethylene(PTFE) grafts may be associated with the migration of outside fibroblasts to the luminal surfaces. In this study we have demonstrated that the migration of outside fibroblasts into inside of the PTFE grafts is indeed participated in the neointima formation by performing a comparative investigation with use of two different types of prosthetic vessels, the porous PTFE graft and the impermeable Grasil graft, respectively.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (31 results)

All 2011 2010 2009 Other

All Journal Article (25 results) (of which Peer Reviewed: 25 results) Presentation (6 results)

  • [Journal Article] Effects of gelatin hydrogel containing chymase inhibitor on scarring in a canine filtration surgery model2011

    • Author(s)
      Kojima S, Sugiyama T, Takai S, Jin D, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Pages: 7672-7680

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Targets of chymase inhibitors2011

    • Author(s)
      Takai S, Jin D, Miyazaki M.
    • Journal Title

      Expert Opin Ther Targets

      Volume: 15 Pages: 519-527

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Irbesartan prevents metabolic syndrome in rats via activation of peroxisome proliferator-activated receptor γ2011

    • Author(s)
      Takai, et al
    • Journal Title

      J Pharmacol Sci

      Volume: 116 Pages: 309-315

    • NAID

      10029895295

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Candesartan and amlodipine combination therapy provides powerful vascular protection in stroke-prone spontaneously hypertensive rats2011

    • Author(s)
      Takai, et al
    • Journal Title

      Hypertens Res

      Volume: 34 Pages: 245-252

    • NAID

      10031163160

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chymase as an important target for preventing complications of metabolic syndrome2010

    • Author(s)
      Takai S, Jin D, Miyazaki M.
    • Journal Title

      Curr Med Chem

      Volume: 17 Pages: 3223-3229

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] New approaches to blockade of the renin-angiotensin-aldosterone system : chymase as an important target to prevent organ damage.2010

    • Author(s)
      Takai, et al
    • Journal Title

      J Pharmacol Sci.

      Volume: 113 Pages: 301-319

    • NAID

      10027745795

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chymase as an important target for preventing complications of metabolic syndrome.2010

    • Author(s)
      Takai, et al
    • Journal Title

      Curr Med Chem

      Volume: 17 Pages: 3223-3229

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters.2010

    • Author(s)
      Komeda, et al
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 832-840

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combination therapy with irbesartan and efonidipine for attenuation of proteinuria in Dahl salt-sensitive rats.2010

    • Author(s)
      Takai, et al
    • Journal Title

      Hypertens Res

      Volume: 33 Pages: 953-959

    • NAID

      10026711303

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet.2010

    • Author(s)
      Tashiro, et al
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 514-523

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of chymase-dependent matrix metalloproteinase-9 activationon indomethacin-induced small intestinal damages in rats.2010

    • Author(s)
      Kakimoto, et al
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 332 Pages: 684-689

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of angiotensin-converting enzyme inhibitor on matrix metalloproteinase-9 activity in patients with Kawasaki disease.2010

    • Author(s)
      Inoue, et al
    • Journal Title

      Clin Chim Acta

      Volume: 411 Pages: 267-269

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice2009

    • Author(s)
      Inoue N, Jin D, Takai S, et al.
    • Journal Title

      Atherosclerosis

      Volume: 204(2) Pages: 359-364

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chymase-dependent conversion of exogenously administered big endothelin-1 in the mouse in vivo2009

    • Author(s)
      Simard E, Jin D, Takai S, et al
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 328(2) Pages: 540-548

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term angiotensin II blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis2009

    • Author(s)
      Jin D, Takai S, et al.
    • Journal Title

      J Pharmacol Sci

      Volume: 109(2) Pages: 275-284

    • NAID

      10025734617

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice2009

    • Author(s)
      Inoue, et al
    • Journal Title

      Atherosclerosis 204

      Pages: 359-364

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term angiotensin II blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis2009

    • Author(s)
      Jin, et al
    • Journal Title

      J Pharmacol Sci 109

      Pages: 275-284

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chymase plays an important role in left ventricular remodeling induced by intermittent hypoxia in mice2009

    • Author(s)
      Matsumoto, et al
    • Journal Title

      Hypertension 54

      Pages: 164-171

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient mice2009

    • Author(s)
      Inoue, et al
    • Journal Title

      J Atheroscler Thromb 16

      Pages: 164-171

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetes2009

    • Author(s)
      Takai, et al
    • Journal Title

      J Pharmacol Sci 110

      Pages: 459-465

    • NAID

      10025738252

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of angiotensin II receptor blockers with high affinity to angiotensin II type 1 receptors for vascular protection in rats2009

    • Author(s)
      Takai, et al
    • Journal Title

      Hypertens Res 32

      Pages: 853-860

    • NAID

      10026123657

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice2009

    • Author(s)
      Takai, et al
    • Journal Title

      J Atheroscler Thromb 16

      Pages: 480-489

    • NAID

      130004444309

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of mitomycin C on the expression of chymase and mast cells in the conjunctival scar of a monkey trabeculectomy model2009

    • Author(s)
      Okada, et al
    • Journal Title

      Mol Vis 13

      Pages: 2029-2036

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chymase-dependent conversion of Big endothelin-1 in the mouse in vivo2009

    • Author(s)
      Simard, et al
    • Journal Title

      J Pharmacol Exp Ther 328

      Pages: 540-548

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outside fibroblasts play a key role in the development of Inner neointima after the implantation of polytetrafluoroethylene grafts

    • Author(s)
      Jin D, Takai S, Li Z, et al.
    • Journal Title

      J Pharmacol Sci

      Volume: (in press)

    • NAID

      10030828453

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] Chymase as a useful target to prevent abdominal aortic aneurysm2011

    • Author(s)
      Takai S, Jin D, Miyazaki M.
    • Organizer
      Keystone Symposia
    • Place of Presentation
      リノ、米国
    • Year and Date
      2011-01-26
    • Related Report
      2011 Final Research Report
  • [Presentation] キマーゼ阻害薬による腹部大動脈瘤進展予防の可能性(シンポジウム)2010

    • Author(s)
      高井真司、金徳男、宮崎瑞夫
    • Organizer
      第38回薬物活性シンポジウム
    • Place of Presentation
      札幌
    • Year and Date
      2010-11-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Combination therapy with angiotensin receptor blocker and T-and L-type calcium channel blocker for attenuation of proteinuria in Dahl-salt sentitive rats2010

    • Author(s)
      Takai S, Jin D, et al.
    • Organizer
      23rd Scientific Meeting of the International Society of Hypertension
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2010-09-26
    • Related Report
      2011 Final Research Report
  • [Presentation] キマーゼ阻害薬のターゲット疾患について(シンポジウム)2010

    • Author(s)
      高井真司、金徳男、宮崎瑞夫
    • Organizer
      第15回日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-08-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 特異的キマーゼ阻害薬TY-51469によるハムスター非アルコール性脂肪性肝炎の阻害効果2010

    • Author(s)
      山本裕美
    • Organizer
      日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-03-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝炎(NASH)ハムスターモデルにおけるキマーゼ阻害薬の効果2009

    • Author(s)
      田代圭太郎
    • Organizer
      第14回日本病態プロテアーゼ学会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2009-08-21
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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