Protective participation of ATP/adenosine axis on the dilated cardiomyopathy of the life-style related diseases model animal.

• Project/Area Number: 21590296
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General pharmacology
• Research Institution: Mukogawa Women's University
• Principal Investigator: SHINOZUKA Kazumasa 武庫川女子大学, 薬学部, 教授 (50117777)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 中枢・末梢神経系 / 虚血再灌流 / ラット心室筋 / ATP放出 / アデノシン放出 / 交感神経機能 / ノルアドレナリン遊離 / 低酸素 / SHRSP.Z-Lepr^<fa>/IzmDmcrラット / プレコンディショナル / ATP / アデノシン / SHR.Z-Lepr^<fa>/IzmDmcrラット / 拡張機能障害 / 心交感神経 / 低酸素状態 / ニコランジル / SHRSP.Z-Lepr^<fa> / IzmDmcrラット / 虚血プレコンディショナル / 拡張機能障害心

Research Abstract

The release of adenosine/ATP from cardiac muscle and the release of noradrenaline from sympathetic nerves were increased by hypoxia. The release of noradrenaline in the condition of hypoxia was significantly inhibited by adenosine(10μM). Adenosine receptor antagonist, 8SPT(30μM) did not influence the release of noradrenaline under the condition of hypoxia. More study is necessary to clarify role of endogenous adenosine on the noradrenaline release under the hypoxic condition.

Research Products

• [Journal Article] 低酸素による血管・心臓交感神経からのノルアドレナリン遊離に対するニコランジルの影響 (2011)
  • Author(s): 多田有加里、鄭婀美、籠田智美、和久田浩一、田邊洋子、橋本道男、篠塚和正
  • Journal Title: Therapeutic Research Volume: 32(2) Pages: 279-282
• [Journal Article] Characterization of cardiac size and function in SHRSP. Z-Lepr(fa)/IzmDmcr rats, a new animal model of metabolic syndrome (2010)
  • Author(s): Tada Y, Kagota S, Matsumoto M, Naito Y, Shibata H, Nejime N, Tsujino T, Koshiba M, Masuyama T, Shinozuka K
  • Journal Title: Biol Pharm Bull Volume: 33(12) Pages: 1971-1976
• [Journal Article] Coronary vascular dysfunction promoted by oxidative-nitrative stress in SHRSP. Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome (2010)
  • Author(s): Kagota S, Fukushima K, Umetani K, Tada Y, Nejime N, Nakamura K, Mori H, Sugimura K, Kunitomo M, Shinozuka K
  • Journal Title: Clin Exp Pharmacol Physiol Volume: 37(11) Pages: 1035-1043
• [Journal Article] Effects of nicorandil on sympathetic neurotransmission in rat caudal artery (2010)
  • Author(s): Tei A, Nejime N, Tada Y, Kagota S, Tanabe Y, Hashimoto M, Shinozuka K
  • Journal Title: Clin Exp Pharmacol Physiol Volume: 37 Pages: 619-623
• [Journal Article] Effect of vanadate on ATP-induced increase in intracellular calcium ion levels in human umbilical vein endothelial cells (2010)
  • Author(s): Nejime N, Tada Y, Kagota S, Tanabe Y, Hashimoto M, Shinozuka K
  • Journal Title: Biol Pharm Bull Volume: 33(6) Pages: 1060-1062
  • NAID: 130000247980
• [Journal Article] Effects of nicorandil on sympathetic neurotransmission in rat caudal artery. (2010)
  • Author(s): Tei A, et al.
  • Journal Title: Clin Exp Pharmacol Physiol. (In press)
  • Peer Reviewed
• [Journal Article] Effect of vanadate on ATP-induced increase in intracellular calcium ion levels in human umbilical vein endothelial cells. (2010)
  • Author(s): Nejime N, et al.
  • Journal Title: Biol Pharm Bull. (In press)
  • Peer Reviewed
• [Presentation] メタボリックシンドロ-ムモデルSHRSP. Z-Lepr^<fa>/IzmDmcrラットに生じる心拍数減少には-酸化窒素が関与する (2010)
  • Author(s): 多田有加里、籠田智美、和久田浩一、中村一基、國友勝、篠塚和正
  • Organizer: 日本薬学会第130年会
• [Presentation] 生活習慣病モデルSHRSP. Z-Lepr^<fa>/IzmDmcrに生じる心機能異常 (2010)
  • Author(s): 多田有加里、籠田智美、禰占奈美江、和久田浩一、中村一基、國友勝、篠塚和正
  • Organizer: 第83回日本薬理学会年会
• [Presentation] Involvement of oxidative stress in impared vasodilation of coronary arteries in SHRSP. Z-Lepr^<fa>/IzmDmcr, an animal model of metabolic syndrome (2009)
  • Author(s): Satomi Kagota, Yukari Tada, Kazuhito Fukushima, Keiji Umetani, Kazuki Namakumra, Masaru Kunitomo, Kazumasa Shinozuka
  • Organizer: Canadian Cardiovascular Congress 2009
  • Place of Presentation: Edmonton, Canada
  • Year and Date: 2009-10-26
• [Presentation] メタボリックシンドロームモデルラットSHRSP. Z-Lepr^<fa>/IzmDmcrに生じる心拍数減少へのNOの関与 (2009)
  • Author(s): 多田有加里、籠田智美、禰占奈美江、和久田浩一、中村一基、篠塚和正
  • Organizer: 第11回応用薬理シンポジウム
• [Presentation] 低酸素下の血管におけるノルアドレナリン遊離に対するニコランジル前処置の影響 (2009)
  • Author(s): 鄭婀美、多田有加里、和久田浩一、籠田智美、中村一基、田邊洋子、橋本道男、篠塚和正
  • Organizer: 第11回応用薬理シンポジウム