Protective participation of ATP/adenosine axis on the dilated cardiomyopathy of the life-style related diseases model animal.
Project/Area Number |
21590296
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General pharmacology
|
Research Institution | Mukogawa Women's University |
Principal Investigator |
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Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 中枢・末梢神経系 / 虚血再灌流 / ラット心室筋 / ATP放出 / アデノシン放出 / 交感神経機能 / ノルアドレナリン遊離 / 低酸素 / SHRSP.Z-Lepr^<fa>/IzmDmcrラット / プレコンディショナル / ATP / アデノシン / SHR.Z-Lepr^<fa>/IzmDmcrラット / 拡張機能障害 / 心交感神経 / 低酸素状態 / ニコランジル / SHRSP.Z-Lepr^<fa> / IzmDmcrラット / 虚血プレコンディショナル / 拡張機能障害心 |
Research Abstract |
The release of adenosine/ATP from cardiac muscle and the release of noradrenaline from sympathetic nerves were increased by hypoxia. The release of noradrenaline in the condition of hypoxia was significantly inhibited by adenosine(10μM). Adenosine receptor antagonist, 8SPT(30μM) did not influence the release of noradrenaline under the condition of hypoxia. More study is necessary to clarify role of endogenous adenosine on the noradrenaline release under the hypoxic condition.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Characterization of cardiac size and function in SHRSP. Z-Lepr(fa)/IzmDmcr rats, a new animal model of metabolic syndrome2010
Author(s)
Tada Y, Kagota S, Matsumoto M, Naito Y, Shibata H, Nejime N, Tsujino T, Koshiba M, Masuyama T, Shinozuka K
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Journal Title
Biol Pharm Bull
Volume: 33(12)
Pages: 1971-1976
Related Report
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