Regulation of placenta development by Wnt signaling

• Project/Area Number: 21590301
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: NAKAMURA Tsutomu 東京大学, 分子細胞生物学研究所, 講師 (30302798)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: シグナル伝達 / 発現制御 / 発生・分化 / 胎盤 / Wnt / Bcl9-like / β-catenin / TCF4 / Gcm1 / 細胞融合 / Syncytin / 【〇!R】-catenin / 絨毛癌

Research Abstract

Cell fusion has a critical role in various developmental processes. However, the signals that regulate cell fusion remain poorly understood. We showed that Wnt signaling directly targets the GCM1/syncytin pathway and thereby regulates the fusion of placental syncytiotrophoblast cells. Our results demonstrate a signal transduction pathway that regulates cell fusion, and may provide intriguing perspectives into the various biological and pathological processes that involve cell fusion.

Research Products

• [Journal Article] Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway (2011)
  • Author(s): Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A,Aburatani H, Nakamura T, Akiyama T
  • Journal Title: Nat Commun Volume: 2 Issue: 1 Pages: 548-548
  • DOI: 10.1038/ncomms1551
  • Peer Reviewed
• [Journal Article] Akiyama T The PX-RICS-14-3-3ζ/θcomplex couples N-cadherin-β-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum (2010)
  • Author(s): Nakamura T, Hayashi T, Mimori-Kiyosue Y, Sakaue F, Matsuura K, Iemura S, Natsume T
  • Journal Title: J Biol Chem 285 Pages: 16145-16154
  • URL: http://www.jbc.org/content/285/21/16145.long
  • Peer Reviewed
• [Presentation] Wnt/β-cateninシグナルが細胞融合シグナルを制御する新規シグナル伝達経路の同定 (2010)
  • Author(s): 松浦憲,地神貴史,谷上賢瑞,森下保幸,足達俊吾,千田隆夫,油谷浩幸,中村勉,秋山徹
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] Wnt/β-cateninシグナルが細胞融合シグナルを制御する新規シグナル伝達経路の同定 (2010)
  • Author(s): 松浦憲
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-22
• [Presentation] PX-RICSはN-cadherin/β-catenin複合体の小胞体-ゴルジ体輸送を制御する.ミニシンポジウム(細胞間接着研究の新展開) (2009)
  • Author(s): 中村勉,林寛敦,那須-西村教子,坂上史佳,森下保幸,夏目徹,松浦憲,秋山徹
  • Organizer: 第61回日本細胞生物学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-06-03
• [Remarks] 報道関連情報(1)プレスリリース「Wntシグナルによる細胞融合制御メカニズムの解明」2011年11月23日
• [Remarks] (2)東大、Wntシグナルによる細胞融合制御のメカニズムを解明マイナビニュース2011年11月25日
• [Remarks] (3)東大、Wntシグナルによる細胞融合制御のメカニズムを解明Yahooニュース2011年12月1日