Regulation of placenta development by Wnt signaling
| Project/Area Number |
21590301
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | シグナル伝達 / 発現制御 / 発生・分化 / 胎盤 / Wnt / Bcl9-like / β-catenin / TCF4 / Gcm1 / 細胞融合 / Syncytin / 【〇!R】-catenin / 絨毛癌 |
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| Research Abstract |
Cell fusion has a critical role in various developmental processes. However, the signals that regulate cell fusion remain poorly understood. We showed that Wnt signaling directly targets the GCM1/syncytin pathway and thereby regulates the fusion of placental syncytiotrophoblast cells. Our results demonstrate a signal transduction pathway that regulates cell fusion, and may provide intriguing perspectives into the various biological and pathological processes that involve cell fusion.
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Report
(4 results)
Research Products
(8 results)
