A novel signal reception mechanism by oligomerization of RAGE and gamma-secretase

• Project/Area Number: 21590304
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kanazawa University
• Principal Investigator: WATANABE Takuo 金沢大学, 医学系, 准教授 (40303268)
• Co-Investigator(Kenkyū-buntansha): YAMAMOTO Hiroshi 金沢大学, 医学系, 教授 (00115198) ; MUNESUE Seiichi 金沢大学, 医学系, 助教 (10399040)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: RAGE / オリゴマー化 / γ-セクレターゼ / マトリックスメタロプロテアーゼ / cAMP / PDE阻害剤 / protease / shedding / phosphodiesterase

Research Abstract

(1) We found a gamma-secretase inhibitor suppressed RAGE signaling by unknown mechanism other than inhibition of gamma-secretase activity.(2) We clarified that the cAMP exerts the inhibitory effects on RAGE signaling by enhancement of MMP9-mediated RAGE shedding that leads to decrease of membrane-bound form RAGE and increase of decoy/soluble form RAGE.(3) We showed the possibility that the PDE inhibitor, which cause enforcement of cAMP signaling could suppress the inflammatory bowel disease using mouse model.

Research Products

• [Journal Article] CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue In flammation and Insulin Resistance by Regulating Both Macrophage Recruitment andM1/M2 Status (2012)
  • Author(s): Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, Sai Y, Takamura T, Yamamoto H, Miyamoto KI, Ginsberg HN, Mukaida N, Kaneko S, Ota T
  • Journal Title: Diabetes Epub
  • Peer Reviewed
• [Journal Article] RAGE mediates vascular injury and inflammation after global cerebral ischemia (2012)
  • Author(s): Kamide T, Kitao Y, Takeichi T, Okada A, Mohri H, Schmidt AM, Kawano T, Munesue S, Yamamoto Y, Yamamoto H, Hamada J, Hori O
  • Journal Title: Neurochem Int Volume: 60 Pages: 220-228
  • Peer Reviewed
• [Journal Article] Endogenous secretory receptor for advanced glycation end-products inhibits amyloid-beta1-42 uptake into mouse brain (2012)
  • Author(s): Sugihara T.
  • Journal Title: J.Alzheimer's Dis. Volume: 28(3) Pages: 709-720
  • Peer Reviewed
• [Journal Article] CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophagerecruitment and M1/M2 status (2012)
  • Author(s): Kitade H.
  • Journal Title: Diabetes Volume: (in press)
  • Peer Reviewed
• [Journal Article] RAGE mediates vascular injury and delayed neuronal death after global cerebral ischemia (2012)
  • Author(s): Kamide T
  • Journal Title: Neurochem Int Volume: 60(3) Pages: 220-228
  • Peer Reviewed
• [Journal Article] Controlling RAGE to conquer diabetic vascular complications (2012)
  • Author(s): Yamamoto Y.
  • Journal Title: J Diabetes Invest Volume: 3(2) Issue: 2 Pages: 107-114
  • DOI: 10.1111/j.2040-1124.2011.00191.x
  • Peer Reviewed
• [Journal Article] Diabetes alters the subsets of mouse endothelial progenitor cells that reside in blood, bone marrow and spleen (2012)
  • Author(s): Saito H.
  • Journal Title: Am J Physiol Cell Physiol Volume: 302(6)
  • Peer Reviewed
• [Journal Article] Anti-HMGB1 monoclonal antibody ameliorates fluid percussion-induced brain injury in rats through protection of BBB and inhibition of inflammatory responses (2012)
  • Author(s): Okuma Y.
  • Journal Title: Ann Neurol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Interaction of receptor for advanced glycation end products with advanced oxidation protein products induces podocyte injury (2012)
  • Author(s): Yamamoto Y.
  • Journal Title: Kidney Int Volume: (in press)
  • Peer Reviewed
• [Journal Article] Diabetes alters subsets of endothelial progenitorcells that reside in blood, bone marrow, and spleen (2011)
  • Author(s): Saito H, Yamamoto Y, Yamamoto H
  • Journal Title: Am J Physiol Cell Physiol Volume: 302
  • Peer Reviewed
• [Journal Article] Regulation of RAGE for attenuating progression of diabetic vascular complications (2011)
  • Author(s): Win MT, Yamamoto Y, Munesue S, Saito H, Han D, Motoyoshi S, Kamal T, Ohara T, Watanabe T, Yamamoto H
  • Journal Title: Exp. Diabetes Res. Epub
  • Peer Reviewed
• [Journal Article] Endogenous Secretory Receptor for AGE Inhibits Amyloid-β^<1-42> Uptake into Mouse Brain J (2011)
  • Author(s): Sugihara T, Munesue S, Yamamoto Y, Sakaurai S, Akhter N, Kitamura Y, Shiba K, Watanabe T, Yonekura H, Hayashi Y, Hamada J, Yamamoto H
  • Journal Title: Alzheimer's Dis Volume: 28 Pages: 709-710
  • Peer Reviewed
• [Journal Article] Gabazza EC : Inhibition of allergic bronchial asthma by thrombomodulin is mediated bydendritic cells (2011)
  • Author(s): Takagi T, Taguchi O, Toda M, Ruiz DB, Bernabe PG, D' Alessandro-Gabazza CN, MiyakeY, Kobayashi T, Aoki S, Chiba F, Yano Y, Conway EM, Munesue S, Yamamoto Y, Yamamoto H, Suzuki K, Takei Y, Morser Y
  • Journal Title: Am. J. Respir Crit. Care Med Volume: 183 Pages: 31-42
  • Peer Reviewed
• [Journal Article] OxLDL-mediated survival of macrophages doesnot require LDL internalization or signalling bymajor pattern recognition receptors (2011)
  • Author(s): Riazy M, Chen JH, Yamamato Y, YamamatoH, Duronio V, Steinbrecher UP
  • Journal Title: Biochem Cell Biol Volume: 89 Pages: 387-395
  • Peer Reviewed
• [Journal Article] Receptor foradvanced glycation end-products(RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes (2011)
  • Author(s): Forbes JM, Soderlund J, Yap FY, Knip M, Andrikopoulos S, Ilonen J, Simell O, Veijola R, Sourris KC, Coughlan MT, Forsblom C, Slattery R, Grey ST, Wessman M, Yamamoto H, BierhausA, Cooper ME, Groop PH
  • Journal Title: Diabetologia Volume: 54 Pages: 1586-1587
  • Peer Reviewed
• [Journal Article] Receptor for advanced glycation end productsbinds to phosphatidylserine and assists in theclearance of apoptotic cells (2011)
  • Author(s): He M, Kubo H, Morimoto K, Fujino N, Suzuki T, Takahasi T, Yamada M, Yamaya M, Maekawa T, Yamamoto Y, Yamamoto H
  • Journal Title: EMBO Rep Volume: 12 Pages: 358-364
  • Peer Reviewed
• [Journal Article] Septic shock is associated with receptor for advanced glycation end products ligation of LPS (2011)
  • Author(s): Yamamoto Y, Harashima A, Saito H, Tsuneyama K, Munesue S, Motoyoshi S, Han D, Watanabe T, Asano M, Takasawa S, Okamoto H, Shimura S, Karasawa T, Yonekura H, YamamotoH
  • Journal Title: J. Immunol Volume: 186 Pages: 3248-3257
  • Peer Reviewed
• [Journal Article] RAGE provides a link between genetic susceptibility and environmental factors in type 1 diabetes (2011)
  • Author(s): Forbes, JM
  • Journal Title: Diabetologia Volume: 54(6) Pages: 1586-1587
  • Peer Reviewed
• [Journal Article] OxLDL-mediated survival of macrophages does not require LDL internalization or signaling by major pattern recognition receptors (2011)
  • Author(s): Riazy M.
  • Journal Title: Biochem Cell Biol. Volume: 89(4) Issue: 4 Pages: 387-395
  • DOI: 10.1139/o11-035
  • Peer Reviewed
• [Journal Article] Regulation of RAGE for attenuating progression of diabetic vascular complications (2011)
  • Author(s): Win MT.
  • Journal Title: Exp.Diabetes Res. Volume: (Epub)
  • Peer Reviewed
• [Journal Article] RAGE-mediated inflammation and diabetic vascular complications (2011)
  • Author(s): Yamamoto Y.
  • Journal Title: J.Diabetes Invest. Volume: 2(3) Issue: 3 Pages: 155-157
  • DOI: 10.1111/j.2040-1124.2011.00125.x
  • Peer Reviewed
• [Journal Article] Significance of advanced glycation end-products (AGE) and the receptor for AGE (RAGE) in diabetic nephropathy (2011)
  • Author(s): Kamal T.
  • Journal Title: Diabetic nepharopathy Volume: (in press)
  • Peer Reviewed
• [Journal Article] Septic shock is associated with receptor for advanced glycation endproducts(RAGE) ligation of LPS. (2011)
  • Author(s): Yamamoto Y.
  • Journal Title: J.Immalogy Volume: 186(5) Pages: 3248-3257
  • Peer Reviewed
• [Journal Article] Inhibition of allergic bronchial asthma by thrombomodulin is mediated by dendritic cells. (2011)
  • Author(s): Takagi T
  • Journal Title: Am.J.Respir.Crit.Cam.Med. Volume: 183 Pages: 31-42
  • Peer Reviewed
• [Journal Article] RAGE provides a link between genetic susceptibility and environmental factors in type 1 diabetes (2011)
  • Author(s): J.M.Forbes
  • Journal Title: Diabetologia Volume: In press
  • Peer Reviewed
• [Journal Article] Receptor for advanced glycation end products binds to phosp hatidylserine and assists in the clearance of apoptotic cells. (2011)
  • Author(s): He M
  • Journal Title: EMBO Rep Volume: 12(4) Pages: 358-364
  • Peer Reviewed
• [Journal Article] The effects of receptor for advanced glycation endproducts(RAGE) on bone metabolism underphysiological and diabetic condition (2010)
  • Author(s): Hamada Y, Kitazawa S, Kitazawa R, Kono K, Goto S, Komaba H, Fujii H, Yamamoto Y, Yamamoto H, Usami M, Fukagawa M
  • Journal Title: Endocrine inpress
  • NAID: 120003338593
  • Peer Reviewed
• [Journal Article] Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity (2010)
  • Author(s): Ichmann A, Burgdorf S, Scheurer S, WaiblerZ, Nagai R, Wellner A, Yamamoto Y, YamamotoH, Henle T, Kurts C, Kalinke U, Vieths S, Toda M
  • Journal Title: J. Allergy Clin. Immunol Volume: 125 Pages: 175-183
  • Peer Reviewed
• [Journal Article] High-mobility group box 1 isinvolved in the initial events of early loss of transplanted islets in mice (2010)
  • Author(s): Matsuoka N, Itoh T, Watarai H, Sekine-Kondo E, Nagata N, Okamoto K, Mera T, Yamamoto H, Yamada S, Maruyama I, TaniguchiM, Yasunami Y
  • Journal Title: J. Clin. Invest Volume: 120 Pages: 735-743
  • NAID: 120002142757
  • Peer Reviewed
• [Journal Article] Receptor for advanced glycationend-products(RAGE) regulation of adiposity and adiponectin is associated with atherogenesis inapo E-deficient mouse (2010)
  • Author(s): Ueno H, Koyama H, Shoji T, Kurato M, Fukumoto S, Tanaka S, Otsuka Y, Mima Y, Morioka T, Mori K, Shioi A, Yamamoto H, InabaM, Nishizawa Y
  • Journal Title: Atherosclerosis Volume: 211 Pages: 431-436
  • Peer Reviewed
• [Journal Article] Recepter for AGEs(RAGE) blockade may exert itsrenoprotective effects in patients with diabetic nephropathy via induction of the angiotensin type2(AT2) receptor (2010)
  • Author(s): Sourris KC, Morley AL, Koitka A, Samuel P, Coughlan MT, Penfold SA, Tomas MC, BierhausA, Nawroth PP, Yamamoto H, Allen TJ, WaltherT, Hussain T, Cooper ME, Forbes JM
  • Journal Title: Diabetologia Volume: 53 Pages: 2442-2451
  • Peer Reviewed
• [Journal Article] Blockade of endothelial-mesenchymal-transitionby a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy (2010)
  • Author(s): Li J, Qu X, Yao J, Caruana G, Ricardo SD, Yamamoto Y, Yamamoto H, Bertram JF
  • Journal Title: Diabetes Volume: 59 Pages: 2612-2624
  • Peer Reviewed
• [Journal Article] Regulation of alternative splicing of the receptorfor advanced glycation endproducts(RAGE) through G-rich cis-elements and heterogenous nuclear ribonucleoprotein(hnRNP) H. J (2010)
  • Author(s): Ohe K, Watanabe T, Harada S, Munesue S, Yamamoto Y, Yonekura H, Yamamoto H
  • Journal Title: Biochem Volume: 147 Pages: 651-659
  • Peer Reviewed
• [Journal Article] The effects of the receptor for advanced glycation end producis(RAGE) on bone metabolism under physiological and diabetic conditions. (2010)
  • Author(s): Hamada Y.
  • Journal Title: J.Endocrine Volume: 38 Pages: 369-376
  • Peer Reviewed
• [Journal Article] Receptor for AGEs(RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin Il type 2(AT2) receptor. (2010)
  • Author(s): K.C.Sourris
  • Journal Title: Diabetologia Volume: 53 Pages: 2442-2451
  • Peer Reviewed
• [Journal Article] Blockade of endothelial-mesenchymal-transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy. (2010)
  • Author(s): Li J
  • Journal Title: Diabetes Volume: 59 Pages: 2612-2624
  • Peer Reviewed
• [Journal Article] Glycation of a food allergen by the Maillard reaction enhances its T-cell immunogenicity : Role of macrophage scavenger receptor class A type I and II (2010)
  • Author(s): Ilchmann A, et al.
  • Journal Title: J Allergy Clin Immunol 125 Pages: 175-83
  • Peer Reviewed
• [Journal Article] Intronic G-stretch switches the membrane-bound type versus secretory type splicing of human receptor for advanced glycation endproducts (RAGE) transcript via interaction with heterogenus nuclear ribonucleoprotein (hnRNP) H (2010)
  • Author(s): Ohe K, et al.
  • Journal Title: Biochemical J (in press)
  • Peer Reviewed
• [Journal Article] High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice (2010)
  • Author(s): Matsuoka, N., et al.
  • Journal Title: J.Clini.Invest. 120 Pages: 735-743
  • Peer Reviewed
• [Journal Article] Receptor for advanced glycation end-products (RAGE) regulation of adiposity and adiponectin is associated with atherogenesis in apo E-deficient mouse (2010)
  • Author(s): Ueno, H., et al.
  • Journal Title: Atherosclerosis (in press)
  • Peer Reviewed
• [Journal Article] Spontaneous bone loss in RIP-iNOS transgenic mouse : a mouse model for diabetes-mediated osteopenia/osteoporosis (2009)
  • Author(s): Mi QS, Yan SL, Wang ZZ, Ding KH, Li C, Wang L, Zhou L, Yamamoto Y, Yamamoto H, Okamoto H, Isales C
  • Journal Title: Cell Cycle Volume: 8 Pages: 4179-4181
  • Peer Reviewed
• [Journal Article] Deletion of RAGE causes hyperactivity and increased sensitivity to auditory stimuli in mice (2009)
  • Author(s): Sakatani S, Yamada K, Homma C, Munesue S, Yamamoto Y, Yamamoto H, Hirase H
  • Journal Title: PLoS ONE Volume: 4
  • NAID: 120006386953
  • Peer Reviewed
• [Journal Article] RAGE mediates oxidizedLDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice (2009)
  • Author(s): Sun L, Ishida T, Yasuda T, Kojima Y, HonjoT, Yamamoto Y, Yamamoto H, Ishibashi S, Hirata K, Hayashi Y
  • Journal Title: Cardiovascular Research Volume: 82 Pages: 371-381
  • Peer Reviewed
• [Journal Article] RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerrosis in non-diabetic LDL receptor-deficient mice (2009)
  • Author(s): L.Sun, et al.
  • Journal Title: Cardiovascular Research 82 Pages: 371-381
  • Peer Reviewed
• [Journal Article] Delection of RAGE causes hyperactivity and increased sensitivity to auditory stimuli in mice (2009)
  • Author(s): Sakatani, S., et al.
  • Journal Title: PLoS ONE 4(12)
  • Peer Reviewed
• [Journal Article] Spontaneous bone loss in RIP-iNOS transgenic mouse : a mouse model for diabetes-mediated osteopenia/osteoporosis (2009)
  • Author(s): Mi QS, et al.
  • Journal Title: Cell Cycle 8(24) Pages: 4179-81
  • Peer Reviewed
• [Presentation] カルボニルストレス代謝制御の解明と統合失調症の診断・治療・予防法の創出 (2011)
  • Author(s): 山本博
  • Organizer: 第44回精神神経系薬物治療研究報告会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
  • Year and Date: 2011-12-02
• [Presentation] カルボニルストレスの臨床応用・橋渡し研究 (2011)
  • Author(s): 山本博
  • Organizer: 第21回日本メイラード学会
  • Place of Presentation: 東京ステーションコンファレンス(東京)(招待講演)
  • Year and Date: 2011-10-28
• [Presentation] 糖尿病合併症の成因について (2011)
  • Author(s): 山本博
  • Organizer: MSD学術講演会-糖尿病と関連疾患を考える会-
  • Place of Presentation: ホテル日航金沢(石川)(招待講演)
  • Year and Date: 2011-08-06
• [Presentation] 血管保護因子・分泌型RAGE生成の制御機構の解析 (2011)
  • Author(s): 大原拓郎
  • Organizer: 日本糖尿病学会
  • Place of Presentation: 札幌プリンスホテル(北海道)
• [Presentation] マウス血管内皮前駆細胞の多様性と糖尿病による動的変化 (2011)
  • Author(s): 齊藤英仁
  • Organizer: 日本糖尿病学会
  • Place of Presentation: 札幌プリンスホテル(北海道)
• [Presentation] 肥満によるインスリン抵抗性の発症にはCCR5による脂肪組織マクロファージの量の変化と質の調節が関わる (2011)
  • Author(s): 澤本一樹
  • Organizer: 日本糖尿病学会
  • Place of Presentation: 札幌プリンスホテル(北海道)
• [Presentation] 糖尿病によって引き起こされる血管内皮前駆細胞の動的変化 (2011)
  • Author(s): 齊藤英仁
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] Pattern recognition receptor RAGE in the pathogenesis of pancreatic beta cell failure in type 2 diabetes (2011)
  • Author(s): H Dong
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] 肥満による炎症とインスリン抵抗性をリンクするCCR5の意義-脂肪組織マクロファージの量及び質の調節への関与 (2011)
  • Author(s): 太田嗣人
  • Organizer: 第26回糖尿病合併症学会
  • Place of Presentation: 大宮ソニックシティ(埼玉)
• [Presentation] 多機能受容体RAGEの分子多様性とアンチエイジングへの応用 (2011)
  • Author(s): 山本靖彦
  • Organizer: 第14回日本補完代替医療学会学術集会アンチエイジングとEBM
  • Place of Presentation: 石川県文教会館(金沢)
• [Presentation] Dynamic alteration in a spatial population of mouse endothelial progenitor cells by diabetes (2011)
  • Author(s): H Saito
  • Organizer: 第19回日本血管分子生物医学会学術集会
  • Place of Presentation: 東京ステーションコンファレンス(東京)
• [Presentation] A Multifunctional Receptor RAGE in Health and Disease. (2010)
  • Author(s): Yamamoto, H
  • Organizer: 2010 Kanazawa-Chonbuk Symposium
  • Place of Presentation: Chonbuk Univ., KOBEA(招待)
  • Year and Date: 2010-10-28
• [Presentation] 食品AGE受容体シグナル伝達系阻害成分の探索 (2010)
  • Author(s): 棟居聖一
  • Organizer: 第20回日本メイラード学会
  • Place of Presentation: お茶の水女子大学(東京)
  • Year and Date: 2010-09-17
• [Presentation] cAMP Exerts Anti-Inflammatory Effects by Controling RAGE Isoform Biogenesis (2010)
  • Author(s): Soh Motoyoshi, Yasuhiko Yamamoto, SeiichiMunesue, Takuo Watanabe, Hiroshi Yamamoto
  • Organizer: 70^<th> American Diabetes Association ScientificSessions
  • Place of Presentation: Orland USA
• [Presentation] Enemies andfriends within in the pathogenesis and preventionof diabetic vascular complications (2010)
  • Author(s): Yamamoto H, Watanabe T, Yamamoto Y, Yonekura H, Munesue S, Ohe K, Sugihara T1, Saito H, Motoyoshi S, Han D, Win MTT, Abou-Zed TK, and Ohara T
  • Organizer: 4^<th> International HMGB1 Symposium-Signals of Tissue Damage
  • Place of Presentation: Helsinki, Finland
• [Presentation] The Role of AGE in Atherosclerosis-Focused on Diabetic Angiopathy (2010)
  • Author(s): Yamamoto, H
  • Organizer: 20^<th> World Congress of International Society for Research
  • Place of Presentation: 京都国際会議場(京都)(招待)
• [Presentation] Enemies and friends within in the pathogenesis and prevention of diabeticic vascular complications. (2010)
  • Author(s): Yamamoto, H
  • Organizer: 4^<th> International HMGB1 Symposium-Signals of Tissue Damage.
  • Place of Presentation: Helsinki Univ., FINL AND(招待)
• [Presentation] CAMP Exerts Anti-Inflammatory Effects by Controling RAGE Isoform Biogenesis (2010)
  • Author(s): Motoyoshi, S
  • Organizer: 70^<th> American Diabetes Association Scientific Sessions
  • Place of Presentation: Orland Convention Ceaster USA(招待)
• [Presentation] 糖尿病腎症とAGE-RAGE系の新展開 (2010)
  • Author(s): 山本靖彦
  • Organizer: 第25回日本糖尿病合併症学会
  • Place of Presentation: びわ湖ホール(滋賀)
• [Presentation] Senscent Macromolecule AGE and Vascular Derangement in Diabetes (2010)
  • Author(s): 山本博
  • Organizer: 第18回日本血管生物医学会学術集会・8^<th> Korea-Japan Joint Symposium_on Vasculaz Biology
  • Place of Presentation: 梅田スカイビル(大阪)
• [Presentation] Receptor for advanced glycation endproducta(RAGE) can bind flagella and host defense against Listeria monocytegenes infection (2010)
  • Author(s): Yamamoto, Y
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫)
• [Presentation] 食品AGEの生物学的評価 (2010)
  • Author(s): 棟居聖一
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫)
• [Presentation] Receptor for advanced glycation endproducts(RAGE) ameliorates LPS-induced septic shock in mice (2010)
  • Author(s): H Saito
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫)
• [Presentation] RAGE・AGER相互作用におけるRAGE Cドメインの関与 (2010)
  • Author(s): 渡邉琢夫
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫)
• [Presentation] Endogenous secretory receptor for advanced glycation endproducts blocks A β uptake into the brain. (2010)
  • Author(s): T Sugihara
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫)
• [Presentation] 血管内皮細胞における細胞保護性RAGEスプラスバリアント (esRAGE) の産生調節機構 (2009)
  • Author(s): 大江和代
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場 (大阪)
• [Presentation] 終末糖化産物受容体 (RAGE) は肥満の進展に影響する (2009)
  • Author(s): 庄司拓仁
  • Organizer: 第40回日本動脈硬化学会総会・学術集会
  • Place of Presentation: つくば国際会議場 (茨城)
• [Presentation] 終末糖化産物受容体 (RAGE) は脳梗塞発症に関与する (2009)
  • Author(s): 大塚淑子
  • Organizer: 第40回日本動脈硬化学会総会・学術集会
  • Place of Presentation: つくば国際会議場 (茨城)
• [Presentation] 血管内皮細胞における細胞保護性RAGEスプラスバリアント (esRAGE) の産生調節機槽 (2009)
  • Author(s): 大江和代
  • Organizer: 第24回日本糖尿病合併症学会
  • Place of Presentation: 岡山コンベンションセンター (岡山)
• [Presentation] RAGEを介した単球/マクロファージにおける炎症惹起とその抑制機構 (2009)
  • Author(s): 本吉創
  • Organizer: 第24回日本糖尿病合併症学会
  • Place of Presentation: 岡山コンベンションセンター (岡山)
• [Presentation] Mechansims for the Development of Diabetic Angiopathy and Its Prevention : Enemies and Friends Within (2009)
  • Author(s): 山本靖彦
  • Organizer: 2^<nd> International Symposium on Adipobiology and Adipopharmacolgy (ISAA)
  • Place of Presentation: Varna 医科大学 (Bulgaria)
• [Presentation] Enemies and Friends Within in the Pathogenesis and Prevention of Diabetic Vasculopathy (2009)
  • Author(s): 山本靖彦
  • Organizer: 2009 International Conference on Vascular Biology
  • Place of Presentation: 国家衛生研究院国際会議場, (TAIWAN)
• [Presentation] RAGEを介した炎症惹起に対するcAMPによる新たな抗炎症作用メカニズム (2009)
  • Author(s): 本吉創
  • Organizer: 第19回日本メイラード学会
  • Place of Presentation: 金沢エクセルホテル東急 (石川)
• [Presentation] アルツハイマー病におけるesRAGEの役割 (2009)
  • Author(s): 杉原崇大
  • Organizer: 第19回日本メイラード学会
  • Place of Presentation: 金沢エクセルホテル東急 (石川)
• [Presentation] RNA結合タンパクhnRNPHによるRAGE mRNA選択的スプライシングの制御 (2009)
  • Author(s): 大江和代
  • Organizer: 第19回日本メイラード学会
  • Place of Presentation: 金沢エクセルホテル東急 (石川)
• [Presentation] LPS誘発 septic shock の病態形成に関わるRAGEの役割 (2009)
  • Author(s): 山本靖彦
  • Organizer: 第19回日本メイラード学会
  • Place of Presentation: 金沢エクセルホテル東急 (石川)
• [Presentation] G-triplets in intron 9 activate the membrane-type RAGE splicing via interaction with hnRNP-H (2009)
  • Author(s): 大江和代
  • Organizer: 第32回日本分子生物学会年会・第82回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場 (兵庫)
• [Presentation] cAMP signal attenuates S100b-induced proinflammatory effect through the regulation of RAGE expression (2009)
  • Author(s): 本吉創
  • Organizer: 第32回日本分子生物学会年会・第82回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場 (兵庫)
• [Presentation] AβとRAGE (receptor for advanced glycation endproducts) の相互作用におけるesRAGE (endoenous secretor RAGE) の役割 (2009)
  • Author(s): 杉原崇大
  • Organizer: 第32回日本分子生物学会年会・第82回日本生化学会大会合同大会
  • Place of Presentation: 神戸国際会議場 (兵庫)
• [Book] 週刊日本医事新報「血管周皮細胞の役割・機能」 (2011)
  • Author(s): 山本博
  • Total Pages: 2
  • Publisher: (株)日本医事新報社
• [Book] 血管生物医学事典第4章AGE受容体 (2011)
  • Author(s): 山本博
  • Total Pages: 2
  • Publisher: (株)朝倉書店
• [Book] 「糖尿病学イラストレイテッド」第4章-2最小血管症発症の分子機構 (2011)
  • Author(s): 山本博
  • Total Pages: 5
  • Publisher: (株)羊土社
• [Book] Medical Practice 12(28) AGE-RAGEと糖尿病合併症予防 (2011)
  • Author(s): 棟居聖一
  • Total Pages: 4
  • Publisher: (株)文光堂
• [Book] 糖化による疾患と抗糖化食品・素材序編-2、1編-5、1編-12 (2010)
  • Author(s): 山本博、久保田浩之、杉原崇大、山本靖彦
  • Publisher: シーエムシー出版
• [Book] 生命への鍵「ステロイド」-その研究に貢献した生化学者と臨床家たち (2009)
  • Author(s): 竹田亮祐、宮森勇、山本博
  • Publisher: 前田書店
• [Book] 生命への鍵「ステロイド」その研究に貢献した生化学者と臨床家たち (2009)
  • Author(s): 山本博, ほか
  • Total Pages: 132
  • Publisher: (株) 前田書店
• [Remarks]
  • URL: http://biochem2.w3.kanazawa-u.ac.jp/index.html
• [Patent(Industrial Property Rights)] アルツハイマー病の診断方法 (2012)
  • Inventor(s): 山本博,米倉秀人,渡邉琢夫,山本靖彦,常山幸一,赤津裕康,川口誠,三浦裕
  • Industrial Property Rights Holder: 国立大学法人金沢大学
  • Filing Date: 2012-02-24
• [Patent(Industrial Property Rights)] RAGEポリペプチドの新規用途 (2012)
  • Inventor(s): 山本博、米倉秀人、渡邉琢夫、山本靖彦、原島愛、唐澤忠宏、志村敏史
  • Industrial Property Rights Holder: 国立大学法人金沢大学
  • Filing Date: 2012-03-23
• [Patent(Industrial Property Rights)] 早期肺癌の術後予後検査方法 (2010)
  • Inventor(s): 久保裕司,小林誠一,鈴木貴,鈴木聡,石沢興太,山本博,米倉秀人,渡辺琢夫,山本靖彦
  • Industrial Property Rights Holder: 国立大学法人金沢大学
  • Filing Date: 2010-07-15
• [Patent(Industrial Property Rights)] esRAGE過剰発現マウス (2009)
  • Inventor(s): 渡邉琢夫、山本博、山本靖彦、棟居聖一、杉原崇大、米倉秀人、櫻井繁
  • Industrial Property Rights Holder: 国立大学法人金沢大学
  • Filing Date: 2009-05-19
• [Patent(Industrial Property Rights)] esRAGE過剰発現マウス (2009)
  • Inventor(s): 山本博, 他
  • Industrial Property Rights Holder: 金沢大学
  • Industrial Property Number: 2009-120572
  • Filing Date: 2009-05-19