| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
RNA interference is an endogenous gene-silencing method that involves double-stranded short RNA(siRNA)-mediated sequence-specific mRNA degradation. Here, we showed intravenously administered siRNA/atelocollagen complex did not induce immunostimulatory adverse effects(interferon-response) in mice. We also found the complex did not entered into peripheral blood mononuclear cells as a reason of the immunostimulatory-null effect of the complex. Atelocollagen is an excellent and promising delivery vehicle, and it has the useful advantage of evading detection by the" radar" of innate immunity.
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